Soft Tissue Infections Clinical Trials

Researchers at the University of Kentucky and Norton HealthCare (Brownsboro location) are inviting patients with symptoms of radiation necrosis to participate in a study. This investigational therapy may reduce or resolve symptoms, such as severe headaches, seizures, and neurological problems, caused by radiation necrosis.

People with necrotizing soft tissue infections are asked to participate in a research study being conducted by Montefiore Medical Center.

The primary hypothesis of this study is that in addition to standard of care treatment (which includes surgical intervention, antimicrobial therapy and critical care support for organ dysfunction or failure), AB103 will demonstrate a clinically significant treatment benefit over placebo. This hypothesis will be addressed by measuring the effect of ...

If you agree to take part in this study, you will be asked to come to the clinic for 2 study visits. First Study Visit: You will be asked questions about your history of tobacco, alcohol, and mouthwash use. You will also be asked questions about your demographic information (such ...

Introduction Necrotizing soft-tissue infections (NSTI) are among the most serious and deadly infections known. They are characterized by rapidly progressing soft-tissue inflammation with necrosis and can quickly cause multiple organ failure and death. Mortality has been shown to be 25-35 %, with survivors coping with amputations and prolonged rehabilitation. Currently, ...

Severe necrotizing soft tissue infection (NSTI), including necrotizing fasciitis, is a life threatening infection that spreads quickly to cutis, sub-cutis, fasciae and muscles. Approximately 40% of all patients with infections caused by S. Pyogenes develop a streptococcal toxic-shock syndrome. In these cases the mortality rates exceed 40% in spite of ...

Hypothesis: The application of a negative pressure wound therapy (NPWT) dressing will reduce rates of wound breakdown in patients with resection of soft tissue sarcomas which are primarily closed. Patients will be randomised into either NPWT or standard absorbent dressings with primary outcome measure of surgical site infection according to ...

HYPOTHESIS: VicrylPlus is superior to Vicryl in terms of infection rate, delayed perineal wound healing and short-/longterm perineal discomfort. Methods: Women given birth at Skne University hospital after November 23, 2015 are assessed for eligibility. The hospital consist of two labor wards with approximately 9.000 deliveries pr year. After birth ...

Hypothesis: We hypothesize that RNAseq will allow us to learn more about the causative agents of necrotizing soft tissue infections (NSTI) and risk factors involved in acquiring these devastating infections Tissue biopsies will be obtained from consented patients admitted with NSTI. Biopsies will be used for standard clinical analysis of ...

Extended description of the protocol, including information not already contained in other fields. Objective: To compare 400 mg of oral moxifloxacin (Oral Group) once daily to 2 grams of IV cefazolin and 1 gram of oral probenecid once daily (IV group) for the treatment of moderate cellulitis. Patients: Any patient ...