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Soft Tissue Infections Clinical Trials

A listing of Soft Tissue Infections medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (12) clinical trials

Researchers at the University of Kentucky and Norton HealthCare (Brownsboro location) are inviting patients with symptoms of radiation necrosis to participate in a study. This investigational therapy may reduce or resolve symptoms, such as severe headaches, seizures, and neurological problems, caused by radiation necrosis.

Phase N/A

Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study

Introduction Necrotizing soft-tissue infections (NSTI) are among the most serious and deadly infections known. They are characterized by rapidly progressing soft-tissue inflammation with necrosis and can quickly cause multiple organ failure and death. Mortality has been shown to be 25-35 %, with survivors coping with amputations and prolonged rehabilitation. Currently, ...

Phase N/A

NPWT in Soft Tissue Sarcoma Surgery

Hypothesis: The application of a negative pressure wound therapy (NPWT) dressing will reduce rates of wound breakdown in patients with resection of soft tissue sarcomas which are primarily closed. Patients will be randomised into either NPWT or standard absorbent dressings with primary outcome measure of surgical site infection according to ...

Phase N/A

Oral Moxifloxacin Versus Cefazolin and Oral Probenecid in the Management of Skin and Soft Tissue Infections in the Emergency Department

Extended description of the protocol, including information not already contained in other fields. Objective: To compare 400 mg of oral moxifloxacin (Oral Group) once daily to 2 grams of IV cefazolin and 1 gram of oral probenecid once daily (IV group) for the treatment of moderate cellulitis. Patients: Any patient ...


Fosfomycin i.v. for Treatment of Severely Infected Patients

The purpose of this European, multicentric, prospective, non-interventional study is to document and evaluate the efficacy and safety of the treatment of severely infected patients with intravenously administered fosfomycin, including patients with osteomyelitis, complicated urinary tract infection, nosocomial lower respiratory tract infection, bacterial meningitis/central nervous system infection, bacteraemia/sepsis, skin and ...

Phase N/A

Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections

The primary hypothesis of this study is that in addition to standard of care treatment (which includes surgical intervention, antimicrobial therapy and critical care support for organ dysfunction or failure), AB103 will demonstrate a clinically significant treatment benefit over placebo. This hypothesis will be addressed by measuring the effect of ...


Incisional Negative Pressure Wound Therapy for Preoperatively Irradiated Lower Extremity Soft Tissue Sarcoma Wounds

Postoperative surgical site infections pose a significant challenge to the orthopaedic oncologist, especially in wounds that have been previously irradiated with neo adjuvant external beam radiation therapy (EBRT). There are many studies demonstrating the relatively high risk of wound complications after lower extremity sarcoma resection. Published data suggest that these ...

Phase N/A

Severe Soft Tissue Infections: Perspectives of Patients and Significant Others

Severe necrotizing soft tissue infection (NSTI), including necrotizing fasciitis, is a life threatening infection that spreads quickly to cutis, sub-cutis, fasciae and muscles. Approximately 40% of all patients with infections caused by S. Pyogenes develop a streptococcal toxic-shock syndrome. In these cases the mortality rates exceed 40% in spite of ...

Phase N/A

Comparison of VicrylPlus Versus Vicryl for Repair of Perineal Tears

HYPOTHESIS: VicrylPlus is superior to Vicryl in terms of infection rate, delayed perineal wound healing and short-/longterm perineal discomfort. Methods: Women given birth at Skne University hospital after November 23, 2015 are assessed for eligibility. The hospital consist of two labor wards with approximately 9.000 deliveries pr year. After birth ...

Phase N/A

RNAseq Analysis of Microbial Gene Expression in Necrotizing Soft Tissue Infections

Hypothesis: We hypothesize that RNAseq will allow us to learn more about the causative agents of necrotizing soft tissue infections (NSTI) and risk factors involved in acquiring these devastating infections Tissue biopsies will be obtained from consented patients admitted with NSTI. Biopsies will be used for standard clinical analysis of ...

Phase N/A