Bone Diseases Clinical Trials

A listing of Bone Diseases medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 35 clinical trials
Reduced Intensity Conditioning (RIC) Regimen for Patients With Non-malignant Disorders (RIC)

for non malignant diseases. Bone Marrow or cord blood will be acceptable as a stem cell source. Recently, reduced intensity conditioning (RIC) regimens have been used for both adult patients

transplant conditioning
melphalan
severe combined immunodeficiency
thalassemia
busulfan
  • 1 views
  • 08 Apr, 2022
  • 1 location
Hypertension Intervention to Reduce Osteonecrosis in Children With Acute Lymphoblastic Leukemia/Lymphoma

This is a randomized unblinded Phase II clinical trial evaluating the impact of intensive antihypertensive control (targeted to the 50-75th percentile for age, sex, and height) compared to conventional antihypertensive control (targeted to the 90-95th percentile for age, sex, and height) on the incidence of radiographically extensive osteonecrosis in children …

lisinopril
lymphoblastic leukemia
ambulatory blood pressure monitoring
antihypertensive drugs
leukemia
  • 0 views
  • 24 Mar, 2022
  • 3 locations
A Study of Denosumab in Multiple Myeloma Patients With Renal Insufficiency

This research study is studying a possible therapy as a possible treatment for the consequences of Multiple Myeloma with renal insufficiency.

monoclonal protein
monoclonal antibodies
calcium
bone marrow procedure
serum calcium
  • 2 views
  • 27 Jan, 2022
  • 7 locations
Study of Infigratinib in Children With Achondroplasia

This is a Phase 2, multicenter, open-label, dose-escalation and dose-expansion study to evaluate the safety, tolerability, and efficacy of infigratinib, a fibroblast growth factor receptor (FGFR) 1-3-selective tyrosine kinase inhibitor, in children 3 to 11 years of age with Achondroplasia (ACH) who previously participated in the PROPEL study (Protocol QBGJ398-001) …

tyrosine kinase inhibitor
  • 45 views
  • 21 Apr, 2022
  • 18 locations
A Study Of Safety, Tolerability And Effectiveness Of Recifercept In Children With Achondroplasia

Approximately 63 participants will be randomized to one of three doses to receive Recifercept either Low Dose Medium Dose High Dose Participants will will attend the clinic at baseline and at Day 1, 4, 8, 15, 29 & then Month 2, 3 6, 9 & 12. Assessments include safety, blood …

testicular
  • 30 views
  • 10 Aug, 2022
  • 11 locations
Extension Study of Infigratinib in Children With Achondroplasia (ACH)

This is a Phase 2, multicenter, open-label, extension (OLE) study to evaluate the long-term safety, tolerability, and efficacy of infigratinib, an FGFR 1-3-selective tyrosine kinase inhibitor, in subjects with ACH who previously completed a QED-sponsored interventional study, and potentially in additional subjects who are naïve to infigratinib treatment. Treatment-naïve subjects …

  • 0 views
  • 26 Apr, 2022
  • 4 locations
Continuation Study of Long-term Safety, Tolerability, Pharmacokinetics and Efficacy of Recifercept in Achondroplasia

All participants who completed the prior study to assess long-term safety, tolerability, pharmacokinetics and efficacy, and in the opinion of the investigator, continue to have a positive risk:benefit profile, will be offered to enroll in this open-label extension (OLE) study for up to an additional 24 months of treatment. Approximately …

  • 0 views
  • 11 Aug, 2022
  • 7 locations
A Dose Escalation Trial Evaluating Safety, Efficacy, and Pharmacokinetics of Multiple Subcutaneous Doses of TransCon CNP Administered Once Weekly in Children With Achondroplasia

Purpose of the study: The main purpose of this study is to determine the safety and evaluate the effect of a once weekly dose of TransCon CNP in prepubertal children with achondroplasia in China. Study Treatments: TransCon CNP is an investigational (new) drug, which means that it is currently being …

testicular
  • 0 views
  • 23 Mar, 2022
  • 2 locations
Efficacy of Zoledronic Acid in Osteoporosis

There has been no comparative data between Zoledronic acid and Zoledronic acid combined with active vitamin D in primary and secondary osteoporosis.

vitamin d
zoledronic acid
secondary osteoporosis
vitamins
osteoporosis
  • 21 views
  • 31 Jan, 2022
  • 1 location
Efficacy of Oral Ibandronate in Osteoporosis

There has been no comparative data between oral ibandronate and oral ibandronate plus active vitamin D

vitamin d
vitamins
ibandronate
osteoporosis
  • 422 views
  • 29 Sep, 2021
  • 1 location