Hepatic Encephalopathy Clinical Trials

A listing of Hepatic Encephalopathy medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 59 clinical trials
Short-term Survival of Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Albumin 5%

This is a Phase 3, multicenter, randomized, controlled, parallel-group, open-label study to evaluate the effects of plasma exchange using human serum albumin 5% (PE-A 5%) in acute-on-chronic liver failure (ACLF) subjects. The study will involve approximately 40 study centers in the United States, Canada, and Europe with expertise in the …

plasma exchange
  • 35 views
  • 07 May, 2021
  • 44 locations
Lactulose for the Prevention of Hepatic Encephalopathy in Cirrhotic Patients With Upper Gastrointestinal Hemorrhage

To evaluate the role of lactulose in prevention of clinically overt hepatic encephalopathy (HE) in the setting of acute upper gastrointestinal bleeding in cirrhotic patients

lactulose
  • 41 views
  • 07 Nov, 2020
  • 1 location
Mesenchymal Stem Cells Treatment for Decompensated Liver Cirrhosis

Decompensated liver cirrhosis is a life-threatening chronic liver disease with high mortality. Liver transplantation is the only option that can improve the survival of these patients; however, this procedure is associated with several limitations, such as the severe shortage of donor livers, long waiting lists, multiple complications, and high cost. …

  • 1 views
  • 23 Jan, 2021
  • 1 location
Role of Probiotics in the Prevention of Spontaneous Bacterial Peritonitis in Cirrhotic Patients: A Randomized Placebo Control Trial

Cirrhotic patients are predisposed to bacterial infection. A large proportion of which is spontaneous bacterial peritonitis(SBP), which are mainly caused by enteric bacteria.SBP in a cirrhotic patients is associated with a high mortality rate in the order of 30-80% per year.It has been demonstrated that cirrhotics who have an ascitic …

cirrhosis
bacterial resistance
antibiotics
norfloxacin
spontaneous bacterial peritonitis
  • 6 views
  • 07 Nov, 2020
  • 1 location
Effect of BCAA Supplementation on Muscle Mass Muscle Quality and Molecular Markers of Muscle Regeneration in CLD Patients

Loss of muscle mass (sarcopenia) is a major complication in a patient with cirrhosis, impacting the disease outcome, quality of life and survival. Cirrhotics lose muscle mass (MM) while waiting for liver transplant (LT) and even after LT, impacting the outcome of LT. Moreover, LT is elusive for majority of …

liver transplant
amino acid
cirrhosis
  • 0 views
  • 19 Feb, 2021
  • 1 location
Study on the Optimal Strategy for Acute-on-chronic Liver Failure With Integrative Treatment

Background: Acute-on-chronic liver failure (ACLF) is a syndrome characterized by acute deterioration in the setting of chronic liver disease associated with high short-term mortality. Currently, there is no specific treatment for patients with ACLF. Our previous results showed that Chinese herbal medicine (CHM) could reduce the mortality rate and the …

liver disease
penta
cytokines
cirrhosis
acute on chronic liver failure
  • 4 views
  • 03 Feb, 2021
  • 15 locations
Rifamycin in Minimal Hepatic Encephalopathy

This is a randomized double-blind placebo-controlled trial of MHE in patients with cirrhosis using rifamycin SV-MMX 600mg BID vs placebo for 30 days with PK, safety, microbiota, brain function and brain MRI endpoints.

MRI
brain mri
platelet count
shear wave elastography
varices
  • 5 views
  • 28 Jan, 2021
  • 1 location
HepQuant to Predict Hepatic Encephalopathy After TIPS

A pilot study to determine if a simple blood test can predict patients at risk for significant episodes of confusion and disorientation that can occur in patients who receive an artificial shunt through the liver to control complications of liver disease.

  • 0 views
  • 27 Jan, 2021
  • 1 location
HEAL STUDY (Hepatic Encephalopathy and Albumin Study)

Patients with continued cognitive impairment after episodes of HE have few options beyond lactulose and rifaximin in the US. Therefore using IV albumin in a randomized, double-blind, placebo-controlled trial, which could beneficially impact inflammation, could be an additional approach to improve cognition. This 6 week trial will study changes in …

psychometric testing
platelet count
varices
flicker
encephalopathy
  • 68 views
  • 25 Jan, 2021
  • 1 location
FMT in Cirrhosis and Hepatic Encephalopathy

Patients with end stage of liver disease or cirrhosis can develop confusion due to high ammonia and inflammation. This confusion is brought upon by changes in the bacteria in the bowels and may not respond to current standard of care treatments. Repeated episodes of confusion can make it difficult for …

platelet count
mini-mental status exam
biopsy of liver
confusion
rifaximin
  • 11 views
  • 28 Apr, 2021
  • 1 location