Hematological Disorders Clinical Trials

A listing of Hematological Disorders medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 228 clinical trials
Dose Escalation Study of Teclistamab a Humanized BCMA CD3 DuoBody Antibody in Participants With Relapsed or Refractory Multiple Myeloma

The purpose of this study is to identify the recommended Phase 2 dose(s) (RP2Ds) and schedule assessed to be safe for Teclistamab and to characterize the safety and tolerability of Teclistamab at the RP2Ds.

proteasome inhibitor
multiple myeloma
estrogen
  • 292 views
  • 06 May, 2021
  • 16 locations
Dose Escalation Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma

The purpose of this study is to characterize the safety of Talquetamab and to determine the recommended Phase 2 dose(s) (RP2Ds) and dosing schedule assessed to be safe for Talquetamab (Part 1 [Dose Escalation]) and to further characterize the safety of Talquetamab at the recommended Phase 2 dose(s) (RP2Ds) (Part …

multiple myeloma
human chorionic gonadotropin
measurable disease
  • 65 views
  • 03 Jun, 2021
  • 16 locations
A Study of the Safety and Tolerability of ABBV-621 in Participants With Previously-Treated Solid Tumors and Hematologic Malignancies

This is an open-label, Phase I, dose-escalation study to determine the maximum tolerated dose (MTD) and/or recommended phase two dose (RPTD), and evaluate the safety, efficacy, and pharmacokinetic (PK) profile of ABBV-621 for participants with previously-treated solid tumors or hematologic malignancies.

bevacizumab
cancer
bone marrow procedure
leukemia
lymphoma
  • 242 views
  • 02 Jun, 2021
  • 25 locations
Study of Tinostamustine First-in-Class Alkylating HDACi Fusion Molecule in Relapsed/Refractory Hematologic Malignancies

This study evaluates the efficacy, safety and pharmacokinetics of tinostamustine (EDO-S101) in patients with relapsed/refractory hematologic malignancies. All patients will receive tinostamustine.

fungal infection
leukemia
cancer
t-cell prolymphocytic leukemia
t-cell lymphoma
  • 0 views
  • 14 Jun, 2021
  • 26 locations
A Study of MGD013 in Patients With Unresectable or Metastatic Neoplasms

The primary goal of this Phase 1 study is to characterize the safety and tolerability of MGD013 and establish the maximum tolerated dose (MTD) of MGD013. Pharmacokinetics (PK), immunogenicity, pharmacodynamics (PD), and the anti-tumor activity of MGD013 will also be assessed.

solid tumour
cancer
erbb2
HER2
measurable disease
  • 534 views
  • 17 Feb, 2021
  • 70 locations
Safety and Tolerability Evaluation of MaaT033

Richness and diversity of gut microbiota are increasingly found to be associated with cancer outcomes. Moreover, an adequately responsive immune system seems to rely on the existence of a functioning gut ecosystem that includes the microbiota and its natural environment. Cancer by itself, but also cancer treatments - in particular …

  • 0 views
  • 27 Jan, 2021
  • 4 locations
Phase I Study of CTL Anti-DP Infusion Post-hematopoietic Stem Cell Transplantation

For several decades, allogeneic hematopoietic stem cell trans-plantation (allo-HSCT) has remained an important strategy in the management of patients with high-risk hematological malignancies. The acceptance of umbilical cord blood (UCBT) and haploidentical grafts (Haplo) as viable alternative donors for allo-HSCT has increased the options for patients with no matched donors …

chronic leukemia
cancer
leukemia
lymphoma
hodgkin's disease
  • 0 views
  • 06 Mar, 2021
  • 1 location
Use of T-allo10 in Hematopoietic Stem Cell Transplantation (HSCT) for Blood Disorders

A significant number of patients with hematologic malignancies need a hematopoietic stem cell transplant (HSCT) to be cured. Only about 50% of these patients have a fully matched donor, the remaining patients will require an HSCT from a mismatched related or unrelated donor. Almost 60% of these mismatched donor HSCTs …

cancer
leukemia
hodgkin's disease
anemia
myeloid leukemia
  • 24 views
  • 16 May, 2021
  • 1 location
The Effectiveness of Lactoferrin in the Management of Treatment-induced Anemia

This will be a randomised control trial designed to test the effectiveness of lactoferrin in the management of treatment-induced anemia in patients with hematological malignancies.

erythropoietin
epoetin alfa
cancer
anemia
cyclophosphamide
  • 7 views
  • 21 Feb, 2021
  • 1 location
Transfusion of Biotinylated Red Blood Cells

The purpose of this research is to study how red blood cells (RBCs) survive in a person's circulation, and how that survival may be different in red blood cells that are donated and stored prior to being transfused. Investigators will study this by collecting blood samples from participants, "labeling" RBCs …

blood transfusion
vitamins
  • 33 views
  • 27 Jan, 2021
  • 1 location