Hematological Disorders Clinical Trials

A listing of Hematological Disorders medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 2099 clinical trials
Durvalumab and Tremelimumab for Pediatric Malignancies

The purpose of the study is to determine the recommended dose of durvalumab and tremelimumab (immunotherapy drugs) in pediatric patients with advanced solid and hematological cancers and expand in a second phase to test the efficacy of these drugs once this dose is determined

acute leukemia
lymphoma
leukemia
durvalumab
cancer
  • 15 views
  • 12 Sep, 2021
  • 27 locations
TRial to EvaluAte Tranexamic Acid Therapy in Thrombocytopenia

The purpose of this study is to test whether giving tranexamic acid to patients receiving treatment for blood cancers reduces the risk of bleeding or death, and the need for platelet transfusions. Patients will be randomised to receive tranexamic acid (given intravenously through a drip, or orally) or a placebo.

tranexamic acid
cell transplantation
hematologic malignancy
cancer
  • 682 views
  • 14 Mar, 2021
  • 28 locations
Myocardial Ischemia and Transfusion

The purpose of this study is to compare two red blood cell transfusion strategies (liberal and restrictive) for patients who have had an acute myocardial infarction and are anemic.

red blood cell transfusion
infarct
myocardial infarction
acute myocardial infarction
ischemia
  • 385 views
  • 02 Sep, 2021
  • 137 locations
Effects of Video-based Health Education on Maternal and Child Health in Ethiopia

Low adherence to recommended health and nutrition strategies during the critical 1000 day-window of opportunity is multifactorial but low quality communication is key limitation. Innovative strategies to improve interpersonal communication can reduce the burden and the fatigue of community health workers and may result in a greater change. The findings …

fatigue
post-natal
bacterial vaginosis
prenatal
  • 25 views
  • 27 Jan, 2021
  • 1 location
Evaluating Innovations in Transition From Pediatric to Adult Care - The Transition Navigator Trial

The Transition Navigator Trial (TNT) is a pragmatic randomized controlled trial evaluating the effectiveness of usual care plus a patient navigator service versus usual care plus newsletters and other educational materials, to improve transition outcomes among adolescents aged 16-21 who have chronic health conditions requiring transfer to adult specialty care. …

  • 188 views
  • 02 May, 2021
  • 3 locations
A Study of the Safety and Tolerability of ABBV-621 in Participants With Previously-Treated Solid Tumors and Hematologic Malignancies

This is an open-label, Phase I, dose-escalation study to determine the maximum tolerated dose (MTD) and/or recommended phase two dose (RPTD), and evaluate the safety, efficacy, and pharmacokinetic (PK) profile of ABBV-621 for participants with previously-treated solid tumors or hematologic malignancies.

leukemia
lymphoma
solid tumour
solid tumor
bone marrow procedure
  • 242 views
  • 02 Jun, 2021
  • 25 locations
Study of Tinostamustine First-in-Class Alkylating HDACi Fusion Molecule in Relapsed/Refractory Hematologic Malignancies

This study evaluates the efficacy, safety and pharmacokinetics of tinostamustine (EDO-S101) in patients with relapsed/refractory hematologic malignancies. All patients will receive tinostamustine.

lymphoma
sezary syndrome
mycosis fungoides
peripheral t-cell lymphoma
multiple myeloma
  • 0 views
  • 14 Jun, 2021
  • 26 locations
Does the Advice to Eat a Mediterranean Diet With Low Carbohydrate Intake Compared With a Low-fat Diet Reduce Diabetes and Cardiovascular Disease?

This is a multi-centre, open, randomised study in patients treated for ischemic heart disease in Linkping, Norrkping and Jnkping hospitals. One thousand two hundred patients who are treated at the cardiac rehabilitation units will be consecutively recruited during three years. The patients will be randomised 1:1 to be given advice …

cardiac rehabilitation
low-fat diet
heart failure
diabetes
heart disease
  • 0 views
  • 22 Jan, 2021
  • 1 location
Allo HSCT Using RIC for Hematological Diseases

This is a phase II trial using a non-myeloablative cyclophosphamide/ fludarabine/total body irradiation (TBI) preparative regimen followed by a related or unrelated donor stem cell infusion. The primary objective is to evaluate rates of acute graft-versus-host disease (GVHD) grades II-IV and chronic GVHD with an updated GVHD prophylaxis of tacrolimus …

lymphoma
follicular lymphoma
renal dysfunction
renal impairment
bone marrow procedure
  • 27 views
  • 31 May, 2021
  • 1 location
Stem Cell Transplant From Donors After Alpha Beta Cell Depletion in Children and Adults With T-allo10 Cells Addback

The purpose of this study is to determine the safety of a cell therapy, T-allo10, after depleted-HSCT in the hopes that it will boost the adaptive immune reconstitution of the patient while sparing the risk of developing severe Graft-versus-Host Disease (GvHD). The primary objective of Phase 1 is to determine …

leukemia
cell transplantation
  • 0 views
  • 26 Jul, 2021
  • 1 location