Late Infantile Neuronal Ceroid Lipfuscinsosis Clinical Trials

A listing of Late Infantile Neuronal Ceroid Lipfuscinsosis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 33 clinical trials
Physiological-based Cord Clamping in Congenital Diaphragmatic Hernia (PinC)

Pulmonary hypertension is a major determinant of postnatal survival in infants with a congenital diaphragmatic hernia (CDH). The current care during the perinatal stabilisation period in infants born with this rare birth defect might contribute to the development of pulmonary hypertension after birth - in particular umbilical cord clamping before …

diaphragmatic hernia
pulmonary hypoplasia
congenital diaphragmatic hernia
resuscitation
hypertension
  • 0 views
  • 12 Jul, 2022
  • 5 locations
A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension (SALTO)

The purpose of this study is to evaluate whether the addition of selexipag to standard of care treatment delays disease progression in children with Pulmonary Arterial Hypertension (PAH) in comparison to placebo.

pulmonary arterial hypertension
heart disease
endothelin
right heart catheterization
endothelin receptor antagonist
  • 247 views
  • 25 Jul, 2022
  • 88 locations
A Study of the Efficacy and Safety of MK-5475 in Participants With Pulmonary Arterial Hypertension (INSIGNIA-PAH: Phase 2/3 Study of an Inhaled sGC Stimulator in PAH) (MK-5475-007)

This is a two-part (Phase 2/Phase 3) study of MK-5475, an inhaled soluble guanylate cyclase stimulator, in participants with pulmonary arterial hypertension (PAH). The first part (Phase 2) will assess three different doses of MK-5475 compared to placebo in a base period of 12 weeks, followed by comparison of three …

pulmonary arterial hypertension
body mass index
heart disease
left ventricular end-diastolic pressure
right heart catheterization
  • 37 views
  • 08 Aug, 2022
  • 71 locations
A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients

Study ROR-PH-301, ADVANCE OUTCOMES, is designed to assess the efficacy and safety of ralinepag when added to pulmonary arterial hypertension (PAH) standard of care or PAH-specific background therapy in subjects with World Health Organization (WHO) Group 1 PAH.

pulmonary arterial hypertension
diuretics
endothelin
calcium
digoxin
  • 6445 views
  • 05 Jul, 2022
  • 228 locations
A Study of Ralinepag to Evaluate Effects on Exercise Capacity by CPET in Subjects With WHO Group 1 PH (CAPACITY)

Study ROR-PH-302, ADVANCE CAPACITY, is designed to evaluate the effects of ralinepag therapy on exercise capacity as assessed by change in peak oxygen consumption (VO2) derived from cardiopulmonary exercise testing (CPET) after 28 weeks of treatment

diuretics
cardiopulmonary exercise testing
endothelin
stress test
exercise stress test
  • 4 views
  • 21 Jul, 2022
  • 35 locations
Inhaled Nitric Oxide for Pulmonary Hypertension and Bronchopulmonary Dysplasia

Inhaled nitric oxide (iNO) is an effective treatment for pulmonary hypertension (PH) in term and near-term infants. Preterm infants are at risk for early PH that is associated with high risk for bronchopulmonary dysplasia or death. In multiple clinical trials, iNO treatment was not effective for BPD prevention. However, infants …

  • 0 views
  • 01 May, 2022
  • 1 location
Study of Angiogenic Cell Therapy for Progressive Pulmonary Hypertension: Intervention With Repeat Dosing of eNOS-enhanced EPCs (SAPPHIRE)

The SAPPHIRE clinical trial seeks to establish the efficacy and safety of repeated monthly dosing of autologous EPCs transfected with human eNOS (heNOS) in patients with symptomatic severe PAH on available PAH-targeted medical therapy.

oxygen saturation
pulmonary arterial hypertension
assisted ventilation
heart disease
left ventricular end-diastolic pressure
  • 10 views
  • 18 May, 2022
  • 6 locations
Hemodynamic Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension (HEXA)

To study hemodynamic effects of acute normobaric hypoxia during exercise in patients with pulmonary hypertension in a single-center randomized controlled trial.

hypoxia
  • 0 views
  • 04 Jun, 2022
  • 1 location
Hemodynamic Effects During Exercise in Patients With Pulmonary Hypertension Receiving Sildenafil (HEXASN)

To study hemodynamic effects of Sildenafil during exercise in patients with pulmonary hypertension.

sildenafil
  • 0 views
  • 05 Jun, 2022
  • 2 locations
A Long-term Extension Study of Riociguat in Patients With Symptomatic Pulmonary Arterial Hypertension. (RIALTO)

To provide riociguat therapy to eligible patients with PAH originating from Bayer-sponsored trials with BAY63-2521/ Riociguat / Adempas® who are currently or recently treated in these trials until lack of patient benefit as assessed by investigator, or commercial availability and reimbursement.

pulmonary arterial hypertension
adempas
riociguat
  • 2 views
  • 11 Jul, 2022
  • 1 location