Late Infantile Neuronal Ceroid Lipfuscinsosis Clinical Trials

A listing of Late Infantile Neuronal Ceroid Lipfuscinsosis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 62 clinical trials
PET/MR Pre- and Post Radiotherapy for Cardiopulmonary Dysfunction Evaluation

Radiotherapy (RT) is a well-known and established therapy or adjuvant therapy for the treatment of thoracic cancer It uses a high energy radiation from x-rays, gamma rays and other charged particles that assist in damaging the cancer DNA. PET/MR as imaging biomarkers for cardiopulmonary dysfunction with a focus on Pulmonary …

cancer
  • 0 views
  • 08 Oct, 2021
  • 1 location
Physiological-based Cord Clamping in Congenital Diaphragmatic Hernia (PinC)

Pulmonary hypertension is a major determinant of postnatal survival in infants with a congenital diaphragmatic hernia (CDH). The current care during the perinatal stabilisation period in infants born with this rare birth defect might contribute to the development of pulmonary hypertension after birth - in particular umbilical cord clamping before …

hypertension
congenital diaphragmatic hernia
pulmonary hypoplasia
resuscitation
umbilical cord clamping
  • 0 views
  • 12 Jul, 2022
  • 5 locations
A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension (SALTO)

The purpose of this study is to evaluate whether the addition of selexipag to standard of care treatment delays disease progression in children with Pulmonary Arterial Hypertension (PAH) in comparison to placebo.

right heart catheterization
pulmonary arterial hypertension
endothelin
primary pulmonary hypertension
heart disease
  • 247 views
  • 25 Jul, 2022
  • 88 locations
A Study of the Efficacy and Safety of MK-5475 in Participants With Pulmonary Arterial Hypertension (INSIGNIA-PAH: Phase 2/3 Study of an Inhaled sGC Stimulator in PAH) (MK-5475-007)

This is a two-part (Phase 2/Phase 3) study of MK-5475, an inhaled soluble guanylate cyclase stimulator, in participants with pulmonary arterial hypertension (PAH). The first part (Phase 2) will assess three different doses of MK-5475 compared to placebo in a base period of 12 weeks, followed by comparison of three …

right heart catheterization
left ventricular end-diastolic pressure
pulmonary arterial hypertension
body mass index
heart disease
  • 37 views
  • 08 Aug, 2022
  • 71 locations
A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients

Study ROR-PH-301, ADVANCE OUTCOMES, is designed to assess the efficacy and safety of ralinepag when added to pulmonary arterial hypertension (PAH) standard of care or PAH-specific background therapy in subjects with World Health Organization (WHO) Group 1 PAH.

right heart catheterization
hypertension
beta-blocker
ralinepag
calcium
  • 6445 views
  • 05 Jul, 2022
  • 228 locations
A Study of Ralinepag to Evaluate Effects on Exercise Capacity by CPET in Subjects With WHO Group 1 PH (CAPACITY)

Study ROR-PH-302, ADVANCE CAPACITY, is designed to evaluate the effects of ralinepag therapy on exercise capacity as assessed by change in peak oxygen consumption (VO2) derived from cardiopulmonary exercise testing (CPET) after 28 weeks of treatment

endothelin
cardiopulmonary exercise testing
ralinepag
stress test
diuretics
  • 4 views
  • 21 Jul, 2022
  • 35 locations
A Study to Assess Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis at Risk for Pulmonary Hypertension (REBUILD)

A randomized, double-blind, placebo-controlled dose escalation and verification study to assess the safety and efficacy of pulsed inhaled nitric oxide (iNO) in subjects at risk for pulmonary hypertension associated with pulmonary fibrosis on long term oxygen therapy (Part 1 and Part 2) - REBUILD

right heart catheterization
left ventricular end-diastolic pressure
pneumonia
rheumatism
pulmonary fibrosis
  • 350 views
  • 16 Mar, 2022
  • 53 locations
L-citrulline and Pulmonary Hypertension Associated With Bronchopulmonary Dysplasia

Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects up to 35% of very low birth weight infants (VLBW < 1500 g). Based on the current numbers of VLBW infants born annually in the U.S., between 5,000-10,000 neonates will develop BPD each year. It is estimated that 8-42% of …

chronic lung disease
very low birth weight
FIO2
assisted ventilation
pulmonary disease
  • 1 views
  • 22 Mar, 2022
  • 1 location
Effects of Treprostinil on Right Ventricular Structure and Function in Patients With Pulmonary Arterial Hypertension

In a group of patients with PAH treated with treprostinil, the current study aims to investigate the effect of treatment on RV structure and function; and correlate changes in RV structure and function with: World Health Organisation (WHO) class, Six-minute walk test, Quality of life (QoL), and Pre-specified biomarkers (N-terminal …

right heart catheterization
walk tests
rheumatism
endothelin receptor antagonist
pulmonary arterial hypertension
  • 9 views
  • 15 Feb, 2022
  • 1 location
ABI-009, an mTOR Inhibitor, for Patients With Severe Pulmonary Arterial Hypertension

mTOR activation has been shown to be relevant in the development and progression of pulmonary hypertension. Inhibition of mTOR has been shown to reverse or regress pulmonary hypertension in animal models. ABI-009 is an albumin-bound mTOR inhibitor with improved penetration in lung tissue.

left ventricular end-diastolic pressure
pulmonary arterial hypertension
primary pulmonary hypertension
pulmonary function test
congenital heart defects
  • 27 views
  • 26 Jan, 2022
  • 6 locations