Chronic Myeloid Leukemia Clinical Trials

A listing of Chronic Myeloid Leukemia medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 152 clinical trials
TyrosIne Kinase Inhibitors in Chronic Myeloid Leukemia: Efficacy and Tolerability. The TIKlet Study (TIKlet)

Rationale The pharmacokinetics of imatinib and nilotinib, two BCR/Abl tyrosine-kinase inhibitors (TKI), is variable among patients suffering from chronic myeloid leukemia (CML

leukemia
tyrosine
nilotinib
imatinib
bcr-abl protein
  • 0 views
  • 24 Mar, 2022
Observational Study in Adults With Imatinib-resistant/Intolerant Chronic Myeloid Leukemia Treated With Nilotinib (CML0609)

The GIMEMA CML Working Party promotes an observational (retrospective and perspective) study of Imatinib-resistant or intolerant CML patients treated with Nilotinib in Italy. Enrollment will

dasatinib
imatinib
leukemia
nilotinib
  • 12 views
  • 25 Mar, 2022
  • 31 locations
Assess Long-term Feasibility of Reduced Dose Dasatinib in Chronic Phase Chronic Myeloid Leukemia Patients

This study is conducted in patients with newly diagnosed CP CML (Chronic Phase Chronic Myeloid Leukemia) who have achieved EMR (< 10% IS BCR-ABL) at 3 months after first line treatment with

dasatinib 100 mg
complete hematologic response
leukemia
chronic phase chronic myeloid leukemia
dasatinib
  • 2 views
  • 17 Feb, 2022
  • 1 location
Observational Study of Conception/Pregnancy in Adult Patients With CML Treated With Tyrosine Kinase Inhibitors (CML1012)

The objective of this study is to acquire more information about what we are doing during pregnancy in CML patients, in order to possibly establish in the future a consensus on the management of

tyrosine
  • 13 views
  • 25 Mar, 2022
  • 36 locations
Special Drug Use-results Surveillance of Scemblix Tablets (Resistant or Intolerant Chronic Myeloid Leukemia , CABL001A1401)

Uncontrolled, central registration system, all-case, multicenter, special drug use-results surveillance.

asciminib
  • 0 views
  • 19 Sep, 2022
  • 26 locations
FLOR3 Gene Polymorphism in Predicting Outcomes of Tyrosine Kinase Inhibitor(TKI)Stopping in Chronic Myeloid Leukemia (NTU-CML-001)

For patients with chronic myeloid leukemia in chronic phase (CML-CP) who have achieved a stable deep molecular response (DMR) using BCR-ABL1 tyrosine kinase inhibitors (TKIs), treatment-free

remission
kinase inhibitor
leukemia
tyrosine
  • 0 views
  • 25 Mar, 2022
  • 1 location
A Study for Tyrosine Kinase Inhibitors Discontinuation

Treatment of Chronic Myeloid Leukemia (CML) has been revolutionized by the use of tyrosine kinase inhibitors including imatinib mesylate (Gleevec, Novartis Laboratories). Two other inhibitors of

chronic myeloid leukemia
myeloid leukemia
nilotinib
remission
imatinib
  • 0 views
  • 22 Jan, 2021
  • 1 location
Dasatinib Down-regulates the Expression of PD-1 and Enhances Killing pH + Leukemia Stem Cells

Research on the mechanism of dasatinib down-regulates the expression of PD-1 in CMV-activated NKG2C+NK cells and enhances killing pH + leukemia stem cells.

dasatinib
leukemia
  • 0 views
  • 16 Aug, 2021
  • 1 location
Long Term Effects of Tyrosine Kinase Inhibitor Therapy on Ovarian Reserve and Fertility in Patients With Chronic Myeloid Leukemia or Gastrointestinal Stromal Tumor

This pilot research trial studies the long term effects of tyrosine kinase inhibitor therapy on ovarian reserve and fertility in patients with chronic myeloid leukemia or gastrointestinal

metastasis
leukemia
tyrosine
kinase inhibitor
cancer
  • 57 views
  • 24 Feb, 2022
  • 1 location
Is There an Association Between Innate CD8+ T Cells and the Evolution of Tyrosine Kinase Inhibitor Resistance Mutations in Phi+ Hematological Malignancies.

cells have an anti-tumor role. This research aims to investigate: An association between the rate of innate CD8+ T cells and the evolution of Phi+ pathologies (Chronic Myeloid Leukemia and

chronic myeloid leukemia
myeloid leukemia
tyrosine
leukemia
philadelphia chromosome
  • 2 views
  • 30 Jul, 2021
  • 1 location