Glomerulonephritis Clinical Trials

A listing of Glomerulonephritis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 11 clinical trials
Study of Efficacy and Safety of LNP023 in Primary IgA Nephropathy Patients

The study is designed as a multicenter, randomized, double-blind, placebo controlled study to demonstrate the superiority of LNP023 at a dose of 200 mg b.i.d. compared to placebo on top of maximally tolerated ACEi or ARB on reduction of proteinuria and slowing renal disease progression in primary IgA Nephropathy patients.

mammogram
fibrosis
proteinuria
adrenaline
treatment regimen
  • 0 views
  • 01 Aug, 2021
  • 100 locations
Atrasentan in Patients With IgA Nephropathy

The ALIGN Study is a phase 3, double-blind, placebo-controlled study to compare the efficacy and safety of atrasentan to placebo in patients with IgA nephropathy (IgAN) at risk of progressive loss of renal function.

renal function
nephropathy
  • 0 views
  • 01 Aug, 2021
  • 58 locations
A Study to Evaluate PF-06730512 in Adults With Focal Segmental Glomerulosclerosis (FSGS)

The purpose of this Phase 2 adaptive study is to evaluate the efficacy, safety, tolerability and pharmacokinetics of PF-06730512 following multiple intravenous infusion in adult subjects with FSGS.

focal segmental glomerulosclerosis
glomerular filtration rate
immunosuppressive agents
total protein
tubulointerstitial fibrosis
  • 226 views
  • 01 Aug, 2021
  • 104 locations
Safety Pharmacokinetics and Preliminary Efficacy Study of CFZ533 in Patients With Lupus Nephritis.

This study is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary therapeutic efficacy of multiple doses of CFZ533 anti-CD40 monoclonal antibody in patients with moderately active lupus nephritis.

proteinuria
antinuclear antibody
mycophenolate
nephritis
histological diagnosis
  • 124 views
  • 31 Jul, 2021
  • 26 locations
Study of Safety Efficacy and Tolerability of Secukinumab Versus Placebo in Combination With SoC Therapy in Patients With Active Lupus Nephritis

The purpose of this trial is to evaluate the efficacy and safety of subcutaneous secukinumab 300 mg compared to placebo, in combination with standard of care therapy (SoC), in subjects with active lupus nephritis (ISN/RPS Class III or IV, with or without co-existing class V features).

urinary sediment
mammogram
glomerular filtration rate
nephritis
  • 37 views
  • 30 Jul, 2021
  • 123 locations
A Study of Guselkumab in Participants With Active Lupus Nephritis

The purpose of this study is to evaluate the efficacy of guselkumab in participants with active lupus nephritis (LN).

mammogram
prednisone
angiotensin
angiotensin receptor blockers
antinuclear antibody
  • 0 views
  • 01 Aug, 2021
  • 69 locations
Efficacy and Safety of VB119 in Subjects With Membranous Nephropathy

This study is a Phase 1b/2a, open-label, sequential-cohort, dose escalation, and dose expansion study to evaluate the safety, tolerability, PK, and PD of VB119 in subjects with primary MN

proteinuria
monoclonal antibodies
follicle stimulating hormone
kidney biopsy
treatment regimen
  • 0 views
  • 30 Jul, 2021
  • 22 locations
Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy

Background Membranous nephropathy is associated with damage to the walls of the glomeruli, the small blood vessels in the kidneys that filter waste products from the blood. This damage causes leakage of blood proteins into the urine and is associated with low blood protein levels, high blood cholesterol values, and …

proteinuria
intravenous infusions
angiotensin ii receptor antagonists
active treatment
angiotensin
  • 236 views
  • 01 Aug, 2021
  • 2 locations
Atrasentan in Patients With Proteinuric Glomerular Diseases

The AFFINITY Study is a phase 2, open-label, basket study to evaluate the efficacy and safety of atrasentan in patients with proteinuric glomerular disease who are at risk of progressive loss of renal function.

type 2 diabetes mellitus
kidney function tests
atrasentan
sglt2
total protein
  • 0 views
  • 17 Jul, 2021
  • 18 locations
Immune System Related Kidney Disease

Kidney diseases related to the immune system include, nephrotic syndrome, glomerulonephritis, membranous nephropathy, lupus nephritis, and nephritis associated with connective tissue disorders

glomerulonephritis
autoimmune diseases
lupus
membranous nephropathy
nephropathy
  • 212 views
  • 28 Jul, 2021
  • 1 location