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Organ Transplant - Pediatric Clinical Trials

A listing of Organ Transplant - Pediatric medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (17) clinical trials

OCS Lung TOP Registry For Donor Lungs for Transplantation

This is an all-comers registry that will enroll: Consented patients who receive OCS preserved double lung transplants from either standard criteria donors or donors initially deemed unacceptable; and Consented patients who receive a single lung transplant from OCS preserved lung pairs from either standard criteria donors or donors initially deemed …

Phase N/A

MRI Technical Development and Applications in Kidney Disease

Specific Aims The overall objective is to develop and validate MRI methods for the evaluation and monitoring of renal status and associated cerebrovascular effects of renal dysfunction and treatment. The proposed project include two phases: 1) MRI technical development and validation with reproducibility studies; 2) clinical pilot studies with two …

Phase N/A

Assessment of the Impact of COVID-19 on Transplant Patients and on Patients Awaiting Transplantation

Transplant Centres (TCs) serve a unique patient population, those with end-organ disease who are either waiting for, or who have received, a solid-organ transplant. For transplant candidates, TCs help weigh the threat of their current condition against the intended benefits and associated risks of transplantation, which include major-surgery and chronic …

Phase N/A

Precision Risk Stratification in Kidney Transplant Patients - EU-TRAIN

Allograft rejection is still a major threat to allografts with thousands of allografts failing every year worldwide due to organ rejection, with immediate consequences for the patients in terms of mortality and morbidity. With a prevalence around 20% in the first-year post transplant, rejection also carries high economic impact representing …

Phase N/A

Cancer Risk in Organ Transplant Recipients and End-Stage Renal Disease

Solid organ transplantation provides life-saving treatment for end-stage organ disease but is associated with substantially elevated cancer risk, largely due to the need to maintain long-term immunosuppression. Despite previous research, important research questions remain concerning the role of immunosuppression and other factors in causing cancer in the setting. Staff at …

Phase N/A

Non-Invasive Rapid Assessment of Patients With Liver Transplants Using Magnetic Resonance Imaging With LiverMultiScan

Long-term survival after solid organ transplantation has increased during the last decade due to improvements in surgical technique, peri-operative care, and more efficient immunosuppression (IS) (1). However, transplant recipients still exhibit higher morbidity and mortality than the general population. One of the main causes are co-morbidities which are negatively influenced …

Phase N/A

Observation Study for Prediction of Allograft Survival and Impact of Imaging in Kidney Transplant Recipients.

The detection of acute rejection in kidney transplant recipients, depends critically on assessments of serum creatinine, an insensitive measure of renal injury and the diagnosis relies on renal transplant needle biopsy which is an invasive procedure associated with a significant risk of bleeding and graft loss and is limited by …

Phase N/A

Urinary Tract Infections in Kidney Transplant Recipients

The risk of UTI after a kidney transplantation is higher than in the general population. MDR bacteria, such as extended spectrum betalactamase (ESBL)-producing enterobacteriaceae or MDR Pseumomoas aeruginosa are emerging threats due to antibiotic selective pressure. Epidemiological data are mostly data from hospital laboratories that do not show a complete …

Phase N/A

EPI-STORM: Cytokine Storm in Organ Donors

Severe neurological injuries such as those observed in neurologically deceased donors (i.e. brain death) trigger a massive cytokine release causing organ injury and affecting the number and quality of all transplanted organs, but particularly the liver. In recipients, elevated serum levels of TNF- are associated with graft dysfunction. In donors, …

Phase N/A

Monocytic Expression of HLA-DR After Liver Transplantation

A defect of the immune response has been described in patients with severe liver disease. This immune-paresis is partly driven by a compensatory anti-inflammatory response following a systemic inflammatory response syndrome and affects the innate immune response. The innate immune defect has been described in patients with advanced cirrhosis and …

Phase N/A