Organ Transplant - Pediatric Clinical Trials

A listing of Organ Transplant - Pediatric medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 83 clinical trials
Tolerance by Engaging Antigen During Cellular Homeostasis

Anti-rejection medicines, also known as immunosuppressive drugs, are prescribed to organ transplant recipients to prevent rejection of the new organ. Long-term use of these medicines places transplant recipients at higher risk of serious infections and certain types of cancer. The purpose of this study is to determine if: it is …

organ transplantation
kidney transplant
belatacept
immunosuppressants
mycophenolate
  • 25 views
  • 14 May, 2021
  • 1 location
CAMPath and BELimumab for Transplant Tolerance in Sensitized Kidney Transplant Recipients

The purpose of this research study is to determine whether kidney transplant recipients who receive belimumab (Benlysta), combined with the standard of care medications for kidney transplant recipients, is safe and effective in helping prevent new donor specific antibodies (DSA) after transplantation. The presence of DSA increases the risk that …

follicle stimulating hormone
hormone replacement therapy (hrt)
kidney transplant
bilateral oophorectomy
tubal ligation
  • 36 views
  • 16 May, 2021
  • 1 location
Contrast-Enhanced Ultrasound for Kidney Transplant

Contrast-enhanced ultrasound (CEUS) is a promising non-invasive imaging tool that may aid in the early detection of kidney transplant complications, such as delayed graft function (DGF) and acute allograft rejection. The technique uses an intravenous contrast agent to improve organ visualization with standard duplex ultrasound equipment. A number of FDA-approved …

contrast-enhanced ultrasound
delayed graft function
kidney transplant
  • 32 views
  • 26 Jan, 2021
  • 1 location
Mesenchymal Stromal Cells in Living Donor Kidney Transplantation

Kidney transplantation is a good treatment option for people with kidney disease. However, there is still much to learn about how to best care for the transplanted kidney and keep it functioning for a long time. Transplant recipients receive induction therapy and immunosuppression (anti-rejection) drugs to prevent their body from …

mycophenolate
corticosteroids
basiliximab
immunosuppression
nephropathy
  • 25 views
  • 28 Jan, 2021
  • 1 location
Evaluation of 2 Techniques of Apheresis to Desensitize ABO Incompatible Kidney Transplant Candidates

Kidney transplantation is the treatment of choice for end-stage renal disease. ABO incompatible (ABOi) living donor kidney transplantation is one of the best ways to expand the donors' pool. However, breaking the ABO barrier is possible only with a preconditioning regimen that includes 1) an immunosuppressive strategy using a B-cell …

kidney transplant
induction therapy
immunosuppressants
immunosuppression
immunosuppressive agents
  • 10 views
  • 25 Jan, 2021
  • 1 location
A Study to Evaluate the Safety and Efficacy of Dual Costimulation Blockade With VIB4920 and Belatacept for Prophylaxis of Allograft Rejection in Adults Receiving a Kidney Transplant

The purpose of this study is to evaluate the efficacy, safety and tolerability of dual costimulation blockade with VIB4920 in combination of belatacept in adult male or female recipients of a renal allograft from a deceased, living unrelated or human leukocyte antigen (HLA) non-identical living related donor.

vaccination
cross-match
immunization schedules
kidney transplant
belatacept
  • 24 views
  • 25 Jan, 2021
  • 2 locations
Effect of Transfusion of Plasma on Endothelial During Liver Transplantation

To study the effects on endothelial condition and short-term outcome in different strategies of plasma transfusion during liver transplantation in patients with end-stage liver disease.

liver disease
cirrhosis
liver transplant
  • 2 views
  • 23 Jan, 2021
  • 1 location
Safety and Efficacy of Camrelizumab (Anti-PD-1 Antibody) in Recurrent HCC After Liver Transplantation

This is a prospective clinical study to investigate the safety and efficacy of anti-PD-1 immunotherapy (Camrelizumab) in patients with recurrent hepatocellular carcinoma (HCC) after liver transplantation. All of the enrolled patients have a background of liver transplantation for HCC. Due to the tumor recurrence, patients are not suitable for curative …

sorafenib
immunohistochemistry
immunosuppression
metastasis
hepatocellular carcinoma
  • 0 views
  • 25 Jan, 2021
  • 1 location
EBD RCT Trial in Living Donor Liver Transplantation

This study was designed to demonstrate incidence of biliary complication rates after living donor liver transplantation according to the implantation of external biliary drainage throug duct-to-duct anastomosis site.

  • 0 views
  • 26 Mar, 2021
  • 1 location
Simplified IMmunosuppressive Protocol Utilizing Low Dose EnvarsusXR

The purpose of this study is to determine if the combination of once-daily tacrolimus extended-release (EnvarsusXR) and Azathioprine is non inferior with respect to the composite outcome of acute rejection, graft and patient survival as compared to a combination of twice-daily immediate release tacrolimus and mycophenolate mofetil/mycophenolic acid.

  • 0 views
  • 08 Mar, 2021
  • 1 location