Chronic Lymphocytic Leukemia Clinical Trials

A listing of Chronic Lymphocytic Leukemia medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 316 clinical trials
A Prospective, Open-Label, Multicenter Randomized Phase III Study to Compare The Efficacy and Safety of A Combined Regimen of Venetoclax and Obinutuzumab Versus Fludarabine, Cyclophosphamide, and Rituximab (FCR)/Bendamustine and Rituximab (BR) in FIT Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL) Without DEL(17P) or TP53 Mutation (CRISTALLO)

participants (FIT is defined by a cumulative illness rating scale [CIRS]/score of ≤6 and a normal creatinine clearance of ≥70 mL/min) with previously untreated CLL without DEL(17P) or TP53 mutation requiring

lymphoid leukemia
platelet count
venetoclax
chronic lymphocytic leukemia
obinutuzumab
  • 0 views
  • 20 Sep, 2022
  • 32 locations
A Phase-3-trial of Acalabrutinib, Obinutuzumab & Venetoclax Compared to Obinutuzumab and Venetoclax in Previously Untreated Patients With High Risk CLL

(GAVe) prolong the progression-free survival (PFS) as compared to treatment with the combination of obinutuzumab and venetoclax (GVe) in pa-tients with high risk CLL (defined as having at least one of

platelet count
gilbert's syndrome
venetoclax
acalabrutinib
obinutuzumab
  • 0 views
  • 27 May, 2022
  • 2 locations
A Phase 1, First-in-Human, Dose Escalation Study of the JNJ-75348780 Bispecific Antibody Targeting CD3 and CD22 in Participants With NHL and CLL

relapsed/ refractory B-cell Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL) in Part A and to further characterize the safety at the RP2D(s) in Part B.

high dose chemotherapy
chronic lymphocytic leukemia
beta human chorionic gonadotrophin
marginal zone lymphoma
tyrosine
  • 14 views
  • 17 Sep, 2022
  • 31 locations
Double-blind, Randomized, Placebo-controlled, Prospective Phase III Study Evaluating Efficacy and Safety of Panzyga in Primary Infection Prophylaxis in Patients With Chronic Lymphocytic Leukemia ("PRO-SID" Study)

Study Evaluating Efficacy and Safety of Panzyga in Primary Infection Prophylaxis in Patients with Chronic Lymphocytic Leukemia

chronic lymphocytic leukemia
igiv
primary infection
  • 8 views
  • 10 Jul, 2022
  • 29 locations
Safety and Efficacy of KRT-232 in Combination With Acalabrutinib in Subjects With R/R DLBCL or R/R CLL

This study evaluates KRT-232, a novel oral small molecule inhibitor of MDM2, combined with acalabrutinib for the treatment of adults with Diffuse Large B-Cell Lymphoma and Chronic Lymphocytic

btk inhibitor
lymphoma
leukemia
diffuse large b-cell lymphoma
b-cell lymphoma
  • 0 views
  • 09 Aug, 2022
  • 45 locations
CD19-specific CAR-T Cells in CLL/SLL and DLBCL

(CAR) and manufactured with a new process. CAR-T cells will be investigated in combination with ibrutinib in chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) and as single agent in

  • 98 views
  • 10 Mar, 2022
  • 19 locations
An Open-Label, Multicenter, Phase I/II Trial Evaluating the Safety, Efficacy, and Pharmacokinetics of Escalating Doses of Mosunetuzumab (BTCT4465A) as a Single Agent and Combined With Atezolizumab in Patients With Relapsed or Refractory B-Cell Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia

and CLL. The study will consist of a dose-escalation stage and an expansion stage where participants will be enrolled into indication-specific cohorts.

lymphoid leukemia
cluster of differentiation
chronic lymphocytic leukemia
hodgkin's disease
lymphoma
  • 1 views
  • 19 Sep, 2022
  • 46 locations
FT596 as a Monotherapy and in Combination With Anti-CD20 Monoclonal Antibodies

This is a Phase I dose-finding study of FT596 as monotherapy and in combination with Rituximab or Obinutuzumab in subjects with relapsed/refractory B-cell Lymphoma or Chronic Lymphocytic

antibody therapy
lymphoid leukemia
lymphocytic leukemia
refractory b-cell non-hodgkin lymphoma
chronic lymphocytic leukemia
  • 0 views
  • 14 Jul, 2022
  • 9 locations
A Multicenter, Open-label, Phase 2 Basket Study to Evaluate the Safety and Efficacy of MK-2140 as a Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies

including mantle cell lymphoma (MCL), Richter's transformation lymphoma (RTL), follicular lymphoma (FL), and chronic lymphocytic leukemia (CLL). This study will also evaluate zilovertamab vedotin as

  • 0 views
  • 23 Sep, 2022
  • 1 location
A Phase 1, First-in-Human, Open-Label Study of the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-67856633, an Inhibitor of MALT1, in Participants With NHL and CLL

and chronic lymphocytic leukemia.

lymphoid leukemia
lymphoma
leukemia
beta human chorionic gonadotrophin
b-cell lymphoma
  • 102 views
  • 20 Aug, 2022
  • 40 locations