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Diabetes and Hypertension Clinical Trials

A listing of Diabetes and Hypertension medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found (587) clinical trials

Genetics of Type 2 Diabetes in West Africans

This research protocol is designed to study the genetic basis of Type 2 Diabetes (T2D) and related conditions in Africa. This project, the Africa America Diabetes Mellitus (AADM) Study, has been continuously funded for over a decade by multiple institutes at NIH including an R01 grant from the NIDDK to …

Phase N/A

Search for New Methods to Detect Acute Renal Failure

The mortality of acute renal failure (ARF) remains high despite advances in supportive care. There are no established effective drug therapies, and dialysis may promote renal injury via hypotension or neutrophil activation. Many agents [e.g., mannitol, furosemide, dopamine, Atrial Natrieuretic Peptide (ANP), Insulin-like Growth Factor (IGF-1), thyroid hormone, etc.] are …

Phase N/A

Chinese Herbal Medicine and Micronized Progesterone for Live Births in Threatened Miscarriage

The causes of spontaneous miscarriage are diverse and comprise chromosomal, genetic, anatomical, immunological, hormonal, infectious and psychological factors, the other factors contribute to an increased risk include advancing paternal and maternal age and mothers with systemic diseases, such as diabetes or thyroid dysfunction. However, the incidence is difficult to determine …

Phase

Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal Cancer

Background Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) is a rare autosomal dominantly inherited disorder which confers susceptibility to develop cutaneous and uterine leiomyomas and renal cell carcinoma. HLRCC is caused by mutations in the Krebs cycle enzyme, fumarate hydratase localized on chromosome 1q42.3-q43. Objectives Define the risk of developing …

Phase N/A

Evaluation of Intestinal Microbiota Manipulation to Treat Resistant Hypertension

The gastrointestinal tract begins its colonization shortly after the birth. During the first two years of life, microbiota is unstable and less diverse than in adulthood, when its complexity and diversity are modified. There are more than 100 trillion microorganisms hosted in the gut, mostly as phylae, Bacteroidetes and Firmicutes. …

Phase N/A

Natural History of Bronchiectasis

Bronchiectasis, or abnormal dilation of the airways, is a condition typically characterized by chronic and recurring respiratory tract infections. Frequently, depending on the underlying cause, these infections involve the entire respiratory tract resulting in sinus, ear, and lung disease. This condition used to be more common in children prior to …

Phase N/A

A Study to Evaluate MEDI5752 in Subjects With Advanced Solid Tumors

This is a phase 1, first-time-in-human, multicenter, open-label, dose-escalation and dose-expansion study to evaluate the safety and tolerability, and efficacy, pharmacokinetics and Immunogenicity of MEDI5752 in adult subjects with advanced solid tumors, when administered as a single agent or combined with chemotherapy.

Phase

The Role of Pregnancy-induced Gallbladder Dysmotility in the Pathophysiology of Gestational Diabetes Mellitus

Gestational diabetes mellitus (GDM) defined as glucose intolerance first detected during pregnancy is a strong predictor of future type 2 diabetes. Patients with GDM exhibit severely reduced postprandial responses of the insulinotropic and satiety-promoting gut hormone glucagon-like peptide 1 (GLP-1), which normalise alongside remission of GDM after delivery. Ingested nutrients …

Phase N/A

Management of Endothelial Dysfunction in Patients With Chronic Venous Insufficiency After Endovenous Surgical Procedure

Each patient will be examined 4 times: Visit 1 (day -1) collecting and documenting patients' complaints and medical history local examination ultrasound angiography of the lower limbs veins assessment of clinical grade according to CEAP classification Visit 2 (day 0) assessment of venous disease severity according to Venous Clinical Severity …

Phase N/A

Image Guided RFA/MWA/CRYO of RCC Biomarker Profile Study

Image-guided ablation therapies are increasingly being used in renal and other cancers as an alternative to major surgery, particularly in the context of small localised masses or when patients have significant co-morbidities. Published analyses now also support the effectiveness of such treatments in terms of outcomes. Tumour ablation has been …

Phase N/A