Allergies & Asthma Clinical Trials

A listing of Allergies & Asthma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 214 clinical trials
A Study to Test if TEV-53275 is Effective in Relieving Asthma

The primary objective of the study is to evaluate the efficacy of TEV-53275 administered subcutaneously (sc) in adult participants with persistent asthma and an eosinophilic phenotype compared to placebo. A secondary objective is to evaluate the efficacy of TEV-53275 compared to placebo assessed by lung function, asthma symptoms, rescue medication …

  • 12 Sep, 2021
  • 60 locations
Single Ascending Dose Study of CM326 in Healthy Volunteers

Single ascending dose study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and immunogenicity of CM326 in healthy volunteers.

  • 03 May, 2021
  • 1 location
A Phase 1 Randomized Double-blind Placebo-controlled Single and Multiple Dose Escalation Study in Healthy Subjects

This is a single center, randomized, double-blind, placebo-controlled, single and multiple dose escalation phase 1 study. The objective of this study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of subcutaneous administered SHR-1819 in healthy subjects

  • 28 Aug, 2021
  • 1 location
Efficacy and Safety of Three Inhaled Dose Levels of AZD1402 Administered for Four Weeks in Adults With Asthma on Medium Dose Inhaled Corticosteroids

This is a randomised, placebo-controlled, double-blinded, multi-centre, 2-part study to assess the efficacy and safety of inhaled AZD1402. Part 1 will be performed in a lead-in cohort for each dose level to evaluate the safety and pharmacokinetics (PK) in a population with asthma controlled on medium dose inhaled corticosteroids (ICS)-long …

  • 18 Sep, 2021
  • 7 locations
Pilot Study to Identify the Mediators and Inflammatory Cell Surface Receptors Involved in Allergic Airway Inflammation

Asthma is a heterogeneous disorder in which multiple potential inflammatory pathways contribute to airway obstruction. The biological basis for airway inflammation is the subject of intensive investigation. This work is designed to identify airway factors that are responsible for recruiting cells and associate their airway presence with atopy and asthma.

skin prick test
airway obstruction
  • 05 Mar, 2021
  • 1 location
Two Doses of the Intravenous Magnesium Sulfate Versus the Standard Single Dose With/ Without the Nebulized Budesonide For the Management of the Severe Asthma Exacerbation in the Emergency Room; A Randomized Controlled Trial.

Many studies have investigated the efficacy and safety of Intravenous magnesium sulfate and inhaled steroids in addition to the standard treatment for patients with severe asthma attacks. In this 2x2 factorial design blinded randomized study, no interaction of hypothesized treatments is expected.Investigators hypothesize that two doses of intravenous magnesium sulfate,a …

inhaled steroids
asthma attack
  • 06 Sep, 2021
  • 1 location
Structure and Function MRI of Asthma

The investigators will apply 129Xenon and/or 3He image acquisition and analysis methods in 120 asthma patient volunteers in order to characterize and probe the relationship between lung structure and function using imaging.

pulmonary function test
  • 23 Jan, 2021
  • 1 location
Bronchial Thermoplasty in Severe Asthma With Frequent Exacerbations

The purpose of this study is to demonstrate the effectiveness of bronchial thermoplasty in a severe asthmatic population with frequent exacerbations. This will be a single center randomized and controlled study. Thirty subjects with severe asthma (Gina 4 and 5) with frequent severe exacerbations (four or more bursts of systemic …

  • 22 Jan, 2021
  • 2 locations
Mechanism(s) of Airflow Limitation During Exacerbation of Asthma

The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory airflow obstruction. Treatment will include inhaled corticosteroids and long acting beta2agonists. The investigators are interested in determining whether the large and/or …

fluticasone / salmeterol
  • 25 Jan, 2021
  • 1 location
A Safety and Efficacy Study of Mepolizumab in Subjects With Severe Asthma

Mepolizumab, a humanized monoclonal antibody, has been developed as an add-on treatment for subjects with severe asthma with eosinophilic inflammation. Current asthma treatment guidelines offer minimal options for the severe asthmatic subjects on intensive therapy with frequent exacerbations. There is a significant unmet medical need to provide better treatment options …

leukotriene receptor antagonist
  • 08 May, 2021
  • 29 locations