Allergies & Asthma Clinical Trials

A listing of Allergies & Asthma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 218 clinical trials
A Study to Evaluate the Effect of Dupilumab on Exercise Capacity in Adult Patients With Asthma

The primary objective of the study is to demonstrate that dupilumab treatment improves exercise capacity in patients with moderate-to-severe asthma. The secondary objectives of the study are: To demonstrate that dupilumab treatment increases physical activity of daily living in patients with moderate-to-severe asthma To demonstrate that dupilumab treatment improves pre- …

leukotriene receptor antagonist
pulmonary function test
theophylline
fluticasone
muscarinic antagonists
  • 35 views
  • 03 Sep, 2021
  • 27 locations
The Effect of Dupilumab on Lung Function and Related Changes in Airway Volumes Detectable by Functional Respiratory Imaging in Patients With Moderate-severe Asthma

Primary Objective: To assess the effect of dupilumab on lung function and related changes in airway volumes detectable by functional respiratory imaging Secondary Objective: To evaluate the effect of dupilumab at Week 24 on bronchodynamics, hyperinflation, airway resistance, airway wall thickness, ventilation defects and mucus plugging derived from high-resolution computed …

leukotriene receptor antagonist
spirometry
pulmonary function test
fractional exhaled nitric oxide
bronchodilator
  • 12 views
  • 22 Jul, 2021
  • 63 locations
Study of Efficacy and Safety of CSJ117 in Patients With Severe Uncontrolled Asthma

The purpose of this study is to determine the efficacy and safety of multiple CSJ117 doses (0.5; 1; 2; 4 and 8 mg) inhaled once daily compared with placebo, when added to standard-of-care (SoC) asthma therapy in adult patients with uncontrolled asthma with respect to change from baseline in FEV1 …

corticosteroids
  • 48 views
  • 22 Sep, 2021
  • 144 locations
Dupilumab Asthma Sleep Study

Primary Objective: To assess the effect of dupilumab on sleep Secondary Objectives: To evaluate the effect of dupilumab on additional patient reported sleep outcomes To evaluate the effect of dupilumab on objective sleep assessment To evaluate the effect of dupilumab on asthma symptoms To evaluate the effect of dupilumab on …

forced expiratory volume
pulmonary function test
corticosteroids
nitric oxide
fractional exhaled nitric oxide
  • 42 views
  • 14 Jun, 2021
  • 40 locations
Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics

The purpose of the study is to evaluate effect of benralizumab on structural and lung function changes in severe eosinophilic asthmatics. Changes will be assessed over 48 week treatment period in patients with persistent symptoms despite standard therapy of inhaled corticosteroids (ICS) plus long acting B2-agonist (LABA) with or without …

benralizumab
pulmonary function test
corticosteroids
fluticasone
airway remodelling
  • 120 views
  • 15 Sep, 2021
  • 49 locations
A Study to Test if TEV-48574 is Effective in Relieving Asthma

The primary objective of the study is to evaluate the effect of TEV-48574 compared with placebo on loss of asthma control (LoAC) in adult patients with T2-low and non-T2 severe asthma uncontrolled on inhaled corticosteroids plus long-acting beta-agonists (ICS+LABA). The secondary efficacy objective is to evaluate the effect of TEV-48574 …

  • 52 views
  • 22 Sep, 2021
  • 82 locations
Study to Assess the Efficacy and Safety of MEDI3506 in Adults With Uncontrolled Moderate-to-severe Asthma

Study D9181C00001 is a Phase II, randomised, double-blind, placebo-controlled, parallel group, proof of concept study to evaluate the efficacy, safety, pharmacokinetics (PK) and immunogenicity of MEDI3506 in adult participants with uncontrolled moderate to severe asthma on standard of care (SOC). Up to approximately 80 sites globally will participate in this …

  • 218 views
  • 12 Sep, 2021
  • 78 locations
A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype

This study will assess whether switching participants who have benefitted from mepolizumab or benralizumab to GSK3511294 (Depemokimab) is non-inferior to maintaining current treatment on the annualized rate of clinically significant exacerbations in participants with severe asthma with an eosinophilic phenotype. Throughout the study, all participants will continue their non-biologic Baseline …

  • 1 views
  • 10 Jul, 2021
  • 48 locations
A Study of GSK3511294 (Depemokimab) in Participants With Severe Asthma With an Eosinophilic Phenotype

This study will assess the efficacy and safety of GSK3511294 (Depemokimab) as an adjunctive therapy in participants with severe uncontrolled asthma with an eosinophilic phenotype despite standard of care (SoC) treatment with medium to high dose inhaled corticosteroid (ICS) plus at least one additional controller.

  • 0 views
  • 17 Sep, 2021
  • 55 locations
Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma (KALOS)

This is a variable length study to evaluate the efficacy and safety of budesonide/glycopyrronium/formoterol inhaler in adults and adolescents with severe asthma inadequately controlled with standard of care.

  • 6 views
  • 23 Sep, 2021
  • 352 locations