Gastrointestinal Diseases and Disorders Clinical Trials

A listing of Gastrointestinal Diseases and Disorders medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 23 clinical trials
Implementing Pharmacogenetic Testing in Gastrointestinal Cancers (IMPACT-GI)

Pharmacogenomics (PGx) is the study of how genes affect a person's response to drugs. PGx testing for certain genes can help predict the risk of side effects from chemotherapy agents. Testing is not regularly performed in clinical practice due to long wait times for results and challenges with integrating test …

cancer
  • 1 views
  • 17 Oct, 2022
  • 3 locations
A First-in-human Phase Ia/b, Open Label, Multicentre, Dose Escalation Study of BI 905711 in Patients With Advanced Gastrointestinal Cancers

Phase Ia - Explore safety and establish the maximum tolerated dose (MTD)/recommended dose levels for phase Ib expansion phase of BI 905711 based on the frequency of patients experiencing dose limiting toxicities (DLTs) during the MTD evaluation period. The MTD evaluation period is defined as the first two treatment cycles …

absolute neutrophil count
gastric adenocarcinoma
carcinoma
endoscopic procedures
liver metastasis
  • 76 views
  • 20 Oct, 2022
  • 14 locations
A Randomized, Controlled Prospective Trial Evaluating The Impact Of A Nurse Navigation Program on Patients With Gastrointestinal Cancers Undergoing Oncological Treatment (ACCESS)

The purpose of this study is to learn about the impact of the Oncology Nurse Navigation program on the frequency of Emergency Department, urgent care visits and inpatient hospital admissions; and overall survival rate at 6 months. The investigators aim to understand if prompt and effective coordination of care provided …

oxaliplatin
capecitabine
5-fluorouracil
cancer
  • 0 views
  • 23 Oct, 2022
  • 1 location
Crossover Trial of Systemic Chemotherapy in Patients With Metastatic Well-Differentiated Mucinous Appendiceal Adenocarcinomas With Pseudomyxoma Peritonei

Appendiceal cancer is a rare disease that does not cause many symptoms. As such, doctors are not sure if chemotherapy actually has an effect on the disease. The goal of this clinical research study is to learn more about the effects that chemotherapy may have on appendiceal cancer.

neutrophil count
absolute neutrophil count
adenocarcinoma
cancer
systemic chemotherapy
  • 20 views
  • 07 Oct, 2022
  • 1 location
Treatment Protocol for the Compassionate Use of Domperidone

This phase III trial studies how well domperidone works in treating patients with gastrointestinal disorders. Domperidone may help control chronic gastrointestinal disorders and their symptoms, such as pain, bloating, and nausea and vomiting, by stimulating contraction of the stomach to increase its ability to empty itself of food.

domperidone
bloating
acidity
blood urea nitrogen
gastric disorder
  • 1578 views
  • 23 Oct, 2022
  • 1 location
A Phase I/II Study Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients

Background A new cancer therapy takes white blood cells from a person, grows them in a lab, genetically changes them, then gives them back to the person. Researchers think this may help attack tumors in people with certain cancers. It is called gene transfer using anti-KRAS G12D mTCR cells. Objective …

absolute neutrophil count
immunoglobulin
amino acids
fludarabine
irinotecan
  • 14 views
  • 22 Oct, 2022
  • 1 location
A Phase I/II Study Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

Background A new cancer therapy involves taking white blood cells from a person, growing them in the lab, genetically modifying them, then giving them back to the person. This therapy is called gene transfer using anti-KRAS G12V mTCR cells. Objective To see if anti-KRAS G12 V mTCR cells are safe …

absolute neutrophil count
immunoglobulin
amino acids
fludarabine
irinotecan
  • 31 views
  • 20 Oct, 2022
  • 1 location
A Study of RGX-202-01 as Combination Therapy in 2nd Line RAS Mutant Advanced Colorectal Cancer

RGX-202-001 is a Phase 1, first-in-human, dose escalation and expansion study of RGX-202-01 as a single agent and in combination with FOLFIRI +/- bevacizumab. RGX-202-01 is a small molecule inhibitor of the creatine transporter SLC6a8, a novel metabolic target that drives gastrointestinal cancer progression. During the dose escalation stage, multiple …

diabetes mellitus
folfiri
adenocarcinoma
thromboplastin
irinotecan
  • 310 views
  • 04 Oct, 2022
  • 5 locations
Advancing Family-Centered Care Nursing Practices in Inpatient Oncology Care

The purpose of this study is to find out if a new training program for nurses called PACT (Partnership, Assessment, Care, and Transition) will be effective and relevant in helping nurses gain the skills needed to provide high-quality family-centered care. Family-centered care skills include engaging family caregivers as partners in …

Accepts healthy volunteers
cancer
  • 0 views
  • 28 Oct, 2022
  • 1 location
Routine Evaluation of the Social Determinants of Health in Oncology: User-centered Resource Coordination and Engagement

The purpose of this research is to understand how screening for patient resource needs followed by customized resource matching can improve outcomes for adults with breast, lung or gastrointestinal cancer.

cancer
  • 0 views
  • 04 Oct, 2022
  • 1 location