Hereditary Cancer Syndromes Clinical Trials

A listing of Hereditary Cancer Syndromes medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 36 clinical trials
Effect of EPA-FFA on Polypectomy in Familial Adenomatous Polyposis

2 Year randomised, double-blind, placebo-controlled, parallel group study to determine the safety and efficacy of EPA-FFA gastro resistant capsules in FAP.

aspirin
rectal anastomosis
eicosapentaenoic acid
colectomy
  • 1 views
  • 26 Jul, 2021
  • 29 locations
Role of Genetic Factors in the Development of Lung Disease

This study is designed to evaluate the genetics involved in the development of lung disease by surveying genes involved in the process of breathing and examining the genes in lung cells of patients with lung disease. The study will focus on defining the distribution of abnormal genes responsible for processes …

bronchoscopy
x-rays
diabetes
pulmonary function test
MRI Scan
  • 301 views
  • 28 Jul, 2021
  • 2 locations
The Cancer of the Pancreas Screening-5 CAPS5)Study

Johns Hopkins clinical research office quality assurance group will monitor and audit this study at Johns Hopkins. The Sub Investigator at each site will be responsible for internal monitoring at their site.

cancer
pancreatitis
palb2
secretin
fammm
  • 185 views
  • 21 Jul, 2021
  • 8 locations
Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

This phase III trial studies combination chemotherapy and atezolizumab to see how well it works compared with combination chemotherapy alone in treating patients with stage III colon cancer and deficient deoxyribonucleic acid (DNA) mismatch repair. Drugs used in combination chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different …

immunosuppressive
fluorouracil
combination chemotherapy
tumor cells
colon cancer
  • 1047 views
  • 29 Jul, 2021
  • 590 locations
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphomas or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists …

total body irradiation
nitrosourea
cellular therapy
bone marrow procedure
olaparib
  • 990 views
  • 28 Jul, 2021
  • 114 locations
Trial of eRapa to Prevent Progression in Familial Adenomatous Polyposis Patients Under Active Surveillance

Patients with Familial Adenomatous Polyposis (FAP) who are undergoing endoscopic surveillance will be given Encapsulated Rapamycin (eRapa) at one of three escalating doses/schedules for 12 months with the aim of reducing polyp burden.

post colectomy
colectomy
endoscopy
  • 0 views
  • 31 Jul, 2021
  • 7 locations
Atypical MOLes and Melanoma Early Detection Study (MoleMed)

This is a multicenter, ambispective, low-interventional clinical study evaluating molecular genetic markers for non-invasive differential diagnosis of benign and malignant pigmented skin and mucosal neoplasms. In retrospective cohorts genetics markers will be identified. In prospective cohort non-invasive adhesive system will be tested to identify malignant or benign lesions with prespecified …

nevus
dermoscopy
skin tumor
  • 0 views
  • 29 Jul, 2021
  • 2 locations
Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors

Patients may be considered if the cancer has come back, has not gone away after standard treatment or the patient cannot receive standard treatment. This research study uses special immune system cells called AGAR T cells, a new experimental treatment. The body has different ways of fighting infection and disease. …

neutrophil count
cancer chemotherapy
experimental drug
cancer
platelet count
  • 0 views
  • 29 Jul, 2021
  • 1 location
Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children Adolescent and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes The 3CI Study

This phase Ib trial investigates the side effects of the combination of nivolumab and ipilimumab, and to see how well they work in treating patients with cancers that have come back (relapsed) or does not respond to treatment (refractory) and have an increased number of genetic changes. Immunotherapy with monoclonal …

lymphoma
neutrophil count
total body irradiation
gene expression
cancer
  • 0 views
  • 22 Jul, 2021
  • 2 locations
Ivosidenib in Treating Patients With Advanced Solid Tumors Lymphoma or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial)

This phase II Pediatric MATCH trial studies how well ivosidenib works in treating patients with solid tumors that have spread to other places in the body (advanced), lymphoma, or histiocytic disorders that have IDH1 genetic alterations (mutations). Ivosidenib may block the growth of cancer cells that have specific genetic changes …

blood transfusion
lymphoma
total body irradiation
chemotherapeutic agents
nitrosourea
  • 37 views
  • 30 Jul, 2021
  • 89 locations