Hereditary Cancer Syndromes Clinical Trials

A listing of Hereditary Cancer Syndromes medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 154 clinical trials
Identifying and Caring for Individuals With Inherited Cancer Syndrome

This trial examines approaches to identify and care for individuals with inherited cancer syndrome. The purpose of this study is to offer no cost genetic testing to the general public

breast cancer
primary cancer
BRCA2
cancer of the ovary
carcinoma in situ
  • 0 views
  • 12 Jun, 2021
  • 2 locations
Dose-Ranging Efficacy and Safety Study of Topical Rapamycin Cream for Facial Angiofibroma Associated With Tuberous Sclerosis Complex

The study aims to compare the safety and efficacy of two different strengths of Rapamycin cream, topical and placebo over 26 weeks in the treatment of facial angiofibroma (FA) associated with Tuberous Sclerosis Complex (TSC).

sirolimus
facial angiofibroma
angiofibroma
  • 34 views
  • 16 Apr, 2021
  • 27 locations
Effect of Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch Syndrome

The proposed trial will evaluate the effect of aspirin 300 mg/d and 100 mg/d during 4 years vs placebo, in a 4 groups randomised parallel design in Lynch syndrome patients: patients with proven carriers of pathological mutations in mismatch repairs genes and patients with personal and family history characterizing Lynch …

acetylsalicylic acid lysinate
adenoma
endoscopy
  • 7 views
  • 25 Jan, 2021
  • 2 locations
Effect of EPA-FFA on Polypectomy in Familial Adenomatous Polyposis

2 Year randomised, double-blind, placebo-controlled, parallel group study to determine the safety and efficacy of EPA-FFA gastro resistant capsules in FAP.

eicosapentaenoic acid
colectomy
rectal anastomosis
aspirin
  • 1 views
  • 26 Jul, 2021
  • 29 locations
Risk-Reducing Surgeries for Hereditary Ovarian Cancer

Based on studies of "Inherited Susceptible Genes Among Epithelial Ovarian Cancer" (NCT03015376, clinicaltrials.gov) and "Cohort Study of Universal Screening for Lynch Syndrome in Chinese Patients of Endometrial Cancer" (NCT03291106, clinicaltrials.gov), we provide risk-reducing surgeries of salpingo-oophorectomy with/without hysterectomy for healthy carriers with mutation genes of hereditary ovarian cancer, which is …

  • 18 views
  • 21 Jan, 2021
  • 1 location
Role of Genetic Factors in the Development of Lung Disease

This study is designed to evaluate the genetics involved in the development of lung disease by surveying genes involved in the process of breathing and examining the genes in lung cells of patients with lung disease. The study will focus on defining the distribution of abnormal genes responsible for processes …

diabetes
sarcoidosis
genetic disorder
chest ct
pulmonary function test
  • 301 views
  • 28 Jul, 2021
  • 2 locations
Pediatric Reporting of Adult-Onset Genomic Results

The Investigators will conduct a longitudinal, mixed-methods cohort study to assess primary and secondary psychosocial outcomes among 705 MyCode pediatric participants and their parents, and health behaviors of parents whose children receive an adult- or pediatric-onset genomic result. Data will be gathered via quantitative surveys using validated measures of distress, …

cancer
heart disease
genetic counseling
  • 4 views
  • 03 Feb, 2021
  • 1 location
The Cancer of the Pancreas Screening-5 CAPS5)Study

Johns Hopkins clinical research office quality assurance group will monitor and audit this study at Johns Hopkins. The Sub Investigator at each site will be responsible for internal monitoring at their site.

fammm
synthetic secretin
secretin
BRCA2
palb2
  • 185 views
  • 21 Jul, 2021
  • 8 locations
Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

This phase III trial studies combination chemotherapy and atezolizumab to see how well it works compared with combination chemotherapy alone in treating patients with stage III colon cancer and deficient deoxyribonucleic acid (DNA) mismatch repair. Drugs used in combination chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different …

adenocarcinoma
oxaliplatin
anaphylactic reactions
antibiotics
antifungal agents
  • 1047 views
  • 29 Jul, 2021
  • 590 locations
Family History Study on Cancer Risk

This study aims to identify the optimal method to recognize, risk stratify, and provide follow-up care for individuals at risk of hereditary cancer. The study team will conduct a Hybrid Type II comparative effectiveness-implementation trial, with a mixed methods component and process/formative evaluations for stakeholder engagement. The study team will …

cancer
familial cancer
  • 0 views
  • 25 Jan, 2021
  • 1 location