Hereditary Cancer Syndromes Clinical Trials

A listing of Hereditary Cancer Syndromes medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 159 clinical trials
Identifying and Caring for Individuals With Inherited Cancer Syndrome

This trial examines approaches to identify and care for individuals with inherited cancer syndrome. The purpose of this study is to offer no cost genetic testing to the general public

BRCA2
primary cancer
breast cancer
ductal carcinoma
carcinoma in situ
  • 21 views
  • 23 Mar, 2022
  • 2 locations
Effect of Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch Syndrome (AAS-Lynch)

The proposed trial will evaluate the effect of aspirin 300 mg/d and 100 mg/d during 4 years vs placebo, in a 4 groups randomised parallel design in Lynch syndrome patients: patients with proven carriers of pathological mutations in mismatch repairs genes and patients with personal and family history characterizing Lynch …

adenoma
acetylsalicylic acid lysinate
endoscopy
  • 13 views
  • 08 Jul, 2022
  • 1 location
Effect of EPA-FFA on Polypectomy in Familial Adenomatous Polyposis

2 Year randomised, double-blind, placebo-controlled, parallel group study to determine the safety and efficacy of EPA-FFA gastro resistant capsules in FAP.

eicosapentaenoic acid
aspirin
colectomy
rectal anastomosis
  • 5 views
  • 10 Feb, 2022
  • 11 locations
Pediatric Reporting of Adult-Onset Genomic Results

The Investigators will conduct a longitudinal, mixed-methods cohort study to assess primary and secondary psychosocial outcomes among 705 MyCode pediatric participants and their parents, and health behaviors of parents whose children receive an adult- or pediatric-onset genomic result. Data will be gathered via quantitative surveys using validated measures of distress, …

heart disease
cancer
genetic counseling
Accepts healthy volunteers
  • 4 views
  • 09 Mar, 2022
  • 1 location
Risk-Reducing Surgeries for Hereditary Ovarian Cancer

Based on studies of "Inherited Susceptible Genes Among Epithelial Ovarian Cancer" (NCT03015376, clinicaltrials.gov) and "Cohort Study of Universal Screening for Lynch Syndrome in Chinese Patients of Endometrial Cancer" (NCT03291106, clinicaltrials.gov), we provide risk-reducing surgeries of salpingo-oophorectomy with/without hysterectomy for healthy carriers with mutation genes of hereditary ovarian cancer, which is …

  • 18 views
  • 21 Jan, 2021
  • 1 location
A Study of JNJ-64251330 in Participants With Familial Adenomatous Polyposis

The purpose of this study is to determine the effect of JNJ-64251330 in participants with Familial Adenomatous Polyposis (FAP) on colorectal polyp burden (sum of the polyp diameters).

  • 0 views
  • 29 Jul, 2022
  • 15 locations
The Cancer of the Pancreas Screening-5 CAPS5)Study (CAPS5)

Johns Hopkins clinical research office quality assurance group will monitor and audit this study at Johns Hopkins. The Sub Investigator at each site will be responsible for internal monitoring at their site.

pancreatitis
synthetic secretin
BRCA1
palb2
secretin
  • 185 views
  • 21 Jul, 2022
  • 8 locations
Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

This phase III trial studies combination chemotherapy and atezolizumab to see how well it works compared with combination chemotherapy alone in treating patients with stage III colon cancer and deficient deoxyribonucleic acid (DNA) mismatch repair. Drugs used in combination chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different …

leucovorin
absolute neutrophil count
investigational agent
hiv viral load
colon cancer
  • 1145 views
  • 08 Aug, 2022
  • 546 locations
Family History Study on Cancer Risk

This study aims to identify the optimal method to recognize, risk stratify, and provide follow-up care for individuals at risk of hereditary cancer. The study team will conduct a Hybrid Type II comparative effectiveness-implementation trial, with a mixed methods component and process/formative evaluations for stakeholder engagement. The study team will …

cancer
familial cancer
  • 0 views
  • 28 Oct, 2021
  • 1 location
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists …

131i-mibg
vemurafenib
absolute neutrophil count
brainstem tumor
iobenguane
  • 1032 views
  • 25 Jul, 2022
  • 106 locations