Pulmonary Arterial Hypertension Clinical Trials

A listing of Pulmonary Arterial Hypertension medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 156 clinical trials
The Prophet Trial -Pilot Study to Assess Safety and Efficacy of a Novel Atrial Flow Regulator (AFR) in Patients With Pulmonary Hypertension (AFR-Prophet)

This study aims to investigate safety and efficacy of Occlutech® AFR device in patients with severe pulmonary hypertension (PH).

right ventricular failure
heart failure
pulmonary arterial pressure
  • 46 views
  • 07 Oct, 2022
  • 12 locations
A Study of Ralinepag to Evaluate Effects on Exercise Capacity by CPET in Subjects With WHO Group 1 PH (CAPACITY)

Study ROR-PH-302, ADVANCE CAPACITY, is designed to evaluate the effects of ralinepag therapy on exercise capacity as assessed by change in peak oxygen consumption (VO2) derived from cardiopulmonary exercise testing (CPET) after 28 weeks of treatment

endothelin receptor antagonist
diuretics
ralinepag
stress test
exercise stress test
  • 4 views
  • 04 Oct, 2022
  • 36 locations
Physiological-based Cord Clamping in Congenital Diaphragmatic Hernia (PinC)

Pulmonary hypertension is a major determinant of postnatal survival in infants with a congenital diaphragmatic hernia (CDH). The current care during the perinatal stabilisation period in infants born with this rare birth defect might contribute to the development of pulmonary hypertension after birth - in particular umbilical cord clamping before …

diaphragmatic hernia
congenital diaphragmatic hernia
resuscitation
umbilical cord clamping
pulmonary hypoplasia
  • 0 views
  • 12 Jul, 2022
  • 5 locations
A Prospective, Randomized, Double-blind, Multicenter, Placebo-controlled, Parallel Group, Adaptive Phase 3 Study With Open-label Extension to Evaluate Efficacy and Safety of Macitentan 75 mg in Inoperable or Persistent/Recurrent Chronic Thromboembolic Pulmonary Hypertension (MACiTEPH)

The purpose of the study is to evaluate the effect of macitentan 75 mg versus placebo on exercise capacity at Week 28 in participants with chronic thromboembolic pulmonary hypertension (CTEPH).

macitentan
  • 85 views
  • 23 Oct, 2022
  • 108 locations
Genetic Testing in Young Adults With Cancer Study

The overarching goal of our research is to define an evidence-based, sustainable approach to identifying and managing genetic risk among young adults with cancer and their relatives. Conventional practice leaves referral and testing decisions to mostly non-expert clinicians implementing complex guidelines at the point of care, leading to substantial under-utilization. …

cancer diagnosis
genetic testing
primary cancer
solid tumor
  • 0 views
  • 20 Oct, 2021
  • 1 location
Tamoxifen Therapy to Treat Pulmonary Arterial Hypertension (T3PAH)

The main purpose of this clinical trial is to examine the feasibility and effects of tamoxifen in subjects with pulmonary arterial hypertension (PAH). The study will evaluate how well the drug

tapse
connective tissue disease
walk tests
hypertension
  • 82 views
  • 04 Oct, 2022
  • 1 location
Interventions Against Insulin Resistance in Pulmonary Arterial Hypertension

or improvement in World Health Organization (WHO) functional class in humans with pulmonary artery hypertension (PAH).

diuretics
hypertension
epoprostenol
  • 3 views
  • 12 Jul, 2022
  • 1 location
Carnitine Consumption and Augmentation in Pulmonary Arterial Hypertension

In preparation for a future mechanistic study, investigators now propose to test the specific hypothesis that carnitine consumption is not reduced in PAH, that plasma carnitine levels are stable

  • 0 views
  • 07 Oct, 2022
  • 1 location
Heart Catheterization Using Magnetic Resonance Imaging (MRI) Fluoroscopy and Passive Guidewires

Background A heart catheterization is a diagnostic heart procedure used to measure pressures and take pictures of the blood flow through the heart chambers. Magnetic resonance imaging (MRI) fluoroscopy shows continuous pictures of the heart chambers that doctors can watch while they work. Researchers want to test this procedure with …

right heart catheterization
heart surgery
  • 20 views
  • 20 Oct, 2022
  • 1 location
The Effect of Oxygen Therapy on 6MWD in PAH and CTEPH Patients With Hypoxemia (SOPHA)

Treatment of O2 naïve patients with PAH will be included in this investigator-initiated trial (IIT) to assess efficacy and safety of oxygen substitution. Nocturnal oxygen substitution improved

pulmonary disease
arterial occlusion
cteph
pulmonary arterial hypertension
hpah
  • 0 views
  • 04 Oct, 2022
  • 1 location