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Affective Disorders Clinical Trials

A listing of Affective Disorders medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (43) clinical trials

rTMS in the Treatment of Bipolar Depression

Bipolar affective disorder is a serious mental illness with significant mortality and morbidity [1]. Some estimates of prevalence in Western populations are as high as 6.4% [2]. The depressive aspect of bipolar disorder is often overlooked, possibly due to its less dramatic nature, despite its significant impact on the lives ...

Phase

Use of Beta Blockers in Elderly Trauma Patients

Methods of Proposed Research 1. Study Design: Prospective, randomized clinical trial. 2. Study Overview: All trauma patients admitted to the ICU > 55 years of age with a primary diagnosis of injury will be screened on admission as study candidates. Patients will be excluded if they have non-survivable injuries, are ...

Phase

Israel Multicenter D-Serine Study (IMSER) for the Treatment of Schizophrenia

The goal of the present study is to evaluate the effect of D-serine, added to antipsychotic treatment, on negative and cognitive symptoms in schizophrenia. The investigators are hypothesizing that D-serine will improve cognitive functioning and negative symptoms.

Phase

Treatment of Psychosis and Agitation in Alzheimer's Disease

Symptoms of psychosis or agitation are common in Alzheimer's disease. These symptoms are associated with distress for the patient, an increased burden for caregivers, more rapid cognitive decline, greater risk of institutionalization and mortality, and increased health care costs. In a recent meta-analysis, caregiver education and behavior modification studies revealed ...

Phase

Effect of IL--1 Inhibition on Inflammation and Cardiovascular Risk

The purpose of this study is to evaluate the effects of IL-1 inhibition on safety, measures of systemic and vascular inflammation and endothelial function (all indicators of cardiovascular risk) in treated and suppressed HIV infected individuals This study will assess the safety and effects of canakinumab on endothelial function (assessed ...

Phase

Investigating the Effects of Dietary Nitrate on Vascular Function Platelet Reactivity and Restenosis in Stable Angina

To address the aims a proof-of-concept study will be conducted to ascertain whether a dietary nitrate approach might prove useful adjunctive therapy improving vascular function in patients with stable angina post elective angioplasty. Design: A prospective randomised, single-centre, double-blind, placebo-controlled trial Setting: Patients with stable angina and single/multiple coronary artery ...

Phase

Saxenda in Obese or Overweight Patients With Stable Bipolar Disorder (Investigator Initiated)

BACKGROUND AND SIGNIFICANCE: Obesity is common among persons with severe mental illness (SMI), especially those with bipolar disorder (BP) (1-5). It is estimated that 45-55% of people with SMI are obese, making obesity 1.5-2 times more common among those with SMI than among the general population. Indeed, in a recent ...

Phase

A Study of MP-101 in Dementia-Related Psychosis and/or Agitation and Aggression

A ten-week study to assess MP-101 in Dementia-Related Psychosis and/or Agitation and Aggression

Phase

Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults

Serum cholesterol is transported by lipoproteins, such as VLDL, LDL and HDL, which vary in their relationship to cardiovascular disease risk. LDL, for example, is proatherogenic, whereas HDL is cardio-protective. Palmitoleic acid (cis-C16:1 n-7), an omega-7 fatty acid with 16 carbons in length with a single double bound in the ...

Phase

The Norwegian Prednisolone in Early Psychosis Study

Objective: The primary objective of this trial is to investigate whether prednisolone improves symptom severity as compared to placebo when given in addition to antipsychotic medication to patients with early-stage psychotic disorder. Secondary objectives include improvement of cognitive functioning and positive, negative and general psychopathological symptoms as well as general ...

Phase