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Affective Disorders Clinical Trials

A listing of Affective Disorders medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (350) clinical trials

Skills for Wellness

The proposed research will test the acceptability and efficacy of an early preventive intervention for the antecedents to severe mental illness with the following hypotheses: Do young people at risk for severe mental illness accept a cognitive-behavioural intervention that targets early antecedents to severe mental illness? Does a cognitive-behavioural intervention ...

Phase N/A

Targeting Cognition in Bipolar Disorder With Pramipexole

All eligible participants will undergo study visits at screening, baseline (week 0), week 1, week 2, week 3, week 4, week 6, week 8, and week 12, (end of study). Randomization will be conducted via a computer generated program and all study staff will be blinded unless un-blinding is required ...


Exenatide Weekly Injections as an Adjunctive Treatment in Patients With Schizophrenia

The specific aims include: Primary aim: Examine the efficacy of exenatide weekly injection in improving negative symptoms as measured by the Scale for the Assessment of Negative Symptoms (SANS) total score. Secondary aims: Examine the efficacy of exenatide in improving cognition as measured by the Measurement and Treatment Research to ...


Depression Obesity and Inflammatory Markers

Aim 1 will examine relationships between the levels of the inflammatory markers and current clinical state (depressed, manic or euthymic) with the hypothesis that Inflammatory markers will be higher in depression and mania relative to the euthymic state. Aim 2 will examine relationships between inflammatory markers and BMI in bipolar ...

Phase N/A

The Bipolar Illness Onset Study (the BIO Study)

The study will include 300 patients with newly diagnosed/first episode bipolar disorder, 200 healthy siblings or child family members and 100 healthy individuals without a family history of affective disorder. All individuals will be investigated with repeated blood tests, Smartphone recordings, neuropsychological tests and brain imaging during a five to ...

Phase N/A

The Canadian Depression Research and Intervention Network (CDRIN) Maritimes Registry

Registry The CDRIN Maritimes registry will provide an integrated platform for clinical research and service evaluation. Participation in the registry will be offered to individuals seeking help for mental disorders across primary, secondary and tertiary care settings in Nova Scotia. In the spirit of participatory research, all participants in the ...

Phase N/A

Building Employment Skills Through Therapy for Veterans

The objective of the current proposal is to evaluate whether integrated cognitive behavior therapy (iCBT) can improve engagement and success in an existing Supported Employment (SE) program among the most functionally disabled patients with schizophrenia/schizoaffective disorder. The iCBT condition also includes computerized cognitive remediation. The primary specific aim is to ...

Phase N/A

Lithium for Suicidal Behavior in Mood Disorders

Objective: To test the hypothesis that lithium augmentation of enhanced usual care will reduce the rate of repeated episodes of suicidal self-directed violence (repeated suicide attempts, interrupted attempts, hospitalizations specifically to prevent suicide, and deaths from suicide) in participants with bipolar disorder or depression who have survived a recent event. ...


MEtformin and Lorcaserin for WeighT Loss in Schizophrenia

Overview of Procedures: All procedures will be conducted at either the UNC Hospitals outpatient clinic in Chapel Hill, NC, at the outpatient North Carolina Psychiatric Research Center (NCPRC), a specialized program of the University of North Carolina Center for Excellence in Community Mental Health in Raleigh, NC or at the ...


Cannabinoids Learning and Memory

This study will be achieved by studying the acute effects of delta-9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis and a cannabinoid-1 receptor (CB1R) agonist, on a wide range of memory tasks in healthy human subjects.