Peripheral Arterial Disease (PAD) Clinical Trials

A listing of Peripheral Arterial Disease (PAD) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 173 clinical trials
Temsirolimus Alone or Paired With Dexamethasone Delivered to the Adventitia to eNhance Clinical Efficacy After Femoropopliteal Revascularization

This is a prospective, multi-center, pilot feasibility study to document the effects of adventitial delivery of temsirolimus or temsirolimus with dexamethasone sodium phosphate injection, USP, after revascularization of femoropopliteal lesions in symptomatic patients with moderate to severe claudication (Rutherford 2-3) or critical limb ischemia (CLI) with rest pain (Rutherford 4). …

atherectomy
foot infection
stenosis
in stent restenosis
balloon angioplasty
  • 8 views
  • 26 Jan, 2021
  • 10 locations
FRAME External Support for Lower Limb Autologous Grafts

30 patients will be enrolled in a prospective, multi-center, one-arm study, enrolling patients with claudication and chronic limb ischemia scheduled for lower limb venous bypass grafting on clinical grounds with single segment autologous saphenous vein. Subjects will be followed for 5 years, with follow up visits at 1, 3, 6, …

stenosis
intermittent claudication
ischemia
revascularisation
limb ischemia
  • 0 views
  • 07 Apr, 2021
  • 3 locations
Angiotensin-(1-7) in Peripheral Arterial Disease

Peripheral arterial disease (PAD) affects over 8 million individuals in the United States alone. This is a form of atherosclerosis in which plaques preferentially build up inside the arteries of

atherosclerosis
stroke
vascular disease
coronary artery disease
arteriopathy
  • 4 views
  • 23 Dec, 2021
  • 1 location
Smartstep Smartphone PAD

The study aim is to evaluate the effectiveness of a coached, smartphone-enabled exercise program versus physician directed exercise therapy (usual care).

intermittent claudication
exercise therapy
  • 77 views
  • 26 Aug, 2021
  • 1 location
ILLUMENATE Below-The-Knee (BTK) Arteries: a Post Market Clinical Study

The objective of this prospective, multi-center, single arm study is to obtain further data on the safety and performance of the StellarexTM 0.014" OTW Drug-coated Angioplasty Balloon in the treatment of lesions in "below the knee" popliteal (P3 segment) and infra-popliteal arteries according to the Instructions for Use in Rutherford-Becker …

stenosis
critical limb ischaemia
balloon angioplasty
ischemia
stenotic
  • 7 views
  • 25 Oct, 2021
  • 10 locations
The Impact of Branched-Chain Amino Acid Metabolism on Limb Dysfunction in PAD

Test the theory that abnormalities in the large blood vessels that deliver blood to your leg and the very small blood vessels in your leg's muscles (invisible to the eye) work together to worsen your leg function and walking.

revascularisation
  • 7 views
  • 18 Sep, 2021
  • 1 location
Hypoxic Exercise in Lower Extremity Artery Disease

The aim of this randomized controlled trial is to: Phase I: To explore, in a first pilot phase, the adequate combination of hypoxia severity and exercise intensity in patients with symptomatic lower extremity artery disease (LEAD). Acute walking performances and physiological responses (vascular and muscular) to a normobaric hypoxic exercise …

  • 0 views
  • 27 Jan, 2021
  • 1 location
Carnosine for Peripheral Vascular Disease

The investigators hypothesise that a home-based standardised exercise intervention with 2g of carnosine daily for 6 months will improve walking endurance in 104 patients with PVD aged 40-80 years compared to placebo and exercise through stabilisation of HIF1- in the ischaemic leg. Aims Aim 1: Determine whether in patients with …

  • 4 views
  • 27 Jan, 2021
  • 1 location
Belgian-Italian Trial to Evaluate the Efficacy and Safety of Below The Knee (BTK) Treatment With the Luminor 14 Paclitaxel Coated Percutaneous Transluminal Angioplasty Balloon Catheter of iVascular

The BIBLIOS trial investigates the efficacy and safety of BTK treatment of patients suffering from critical limb ischemia (Rutherford 5) with the Luminor-14 Paclitaxel coated Percutaneous Transluminal Angioplasty Balloon catheter of iVascular. An expected total of 150 patients will be treated. Infrapopliteal lesions will be treated during this trial. The …

limb ischemia
stenosis
paclitaxel
ischemia
revascularisation
  • 0 views
  • 18 Sep, 2021
  • 8 locations
A Study Evaluating the Endovascular Treatment of Subjects With Stenotic or Restenotic Lesions of the Common Femoral Artery With the Supera Vascular Mimetic Implant Compared to Surgical Common Femoral Artery Endarterectomy

The SUPERSURG RCT trial investigates the efficacy and safety of the endovascular treatment of stenosis or restenosis in the common femoral artery (CFA) of patients presenting with Rutherford classification 2,3 or 4 with a Supera Vascular Mimetic Implant of Abbott, compared to classic surgical common femoral artery endarterectomy. The Supera …

revascularisation
stenosis
stenotic
  • 0 views
  • 18 Sep, 2021
  • 10 locations