Progressive Multifocal Leukoencephalopathy (PML) Clinical Trials
A listing of Progressive Multifocal Leukoencephalopathy (PML) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Found 9 clinical trials
Dynamics of T Cell Expression of Immune Checkpoint Molecules in Progressive Multifocal Leukoencephalopathy
Progressive multifocal leukoencephalopathy (PML) is a rare viral infection of the central nervous system (CNS) occurring in immunocompromised patients. Recovery of JC virus (JCV) specific T cell
- 0 views
- 12 Mar, 2021
- 4 locations
NT-I7 a Long-Acting Recombinant IL-7 Molecule as an Immune Reconstitution Strategy for Lymphopenia in Patients With Progressive Multifocal Leukoencephalopathy
Background Progressive multifocal leukoencephalopathy (PML) is a brain infection. It is caused by a virus. PML can happen in people with a weakened immune system
- 0 views
- 16 May, 2021
- 1 location
Treatment of PD-1 Inhibitor in AIDS-associated PML
PD-1 inhibitor Pembrolizumab, 2mg/kg weight, once per 4 weeks and 3 times of medication usagetreatment on AIDS patients with progressive multifocal leukoencephalopathy.
- 0 views
- 23 Jan, 2021
- 1 location
Sub-Study: Analysis of JCV Antibody Index in MS Patients Treated With Teriflunomide - SWITCH-JCV
The purpose of this study is to determine if teriflunomide will be safe and effective to prevent relapses in patients with relapsing types of MS when switching from natalizumab to teriflunomide in patients at risk for PML. This is a two center interventional study of patients who have had 12 …
- 0 views
- 24 Jan, 2021
- 3 locations
A Pilot Study to Characterize the Biological Effect of a Pre-planned 12 Week Dose Interruption of Natalizumab
This is an open-label study of patients with relapsing forms of MS is designed to assess the biochemical, immunological, and kinetic profiles of natalizumab being used with specific brief dosing interruption. The study will be conducted at one site in the US. Ten subjects currently treated with natalizumab will be …
- 0 views
- 31 Jul, 2021
- 1 location
Autologous Stem Cell Transplant for Crohn's Disease
Crohn's Disease (CD) is an inflammatory bowel disease. It can lead to significant complications and discomfort in the stomach and intestines. Crohn's disease is a debilitating, incurable disease of immune cells; it affects almost 1 million people in the United States. CD is characterized by inflammation of the stomach and …
- 66 views
- 25 Jan, 2021
- 1 location
Real World Effectiveness of Natalizumab Extended Interval Dosing in a French Cohort
with its efficacy, NTZ use has been limited by potential risk of progressive multifocal leukoencephalopathy (PML). Thus, several studies have tried to assess how to minimize this risk. One
- 0 views
- 05 Sep, 2021
- 5 locations
Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)
Background Progressive multifocal leukoencephalopathy (PML) is a severe viral infection of the brain. It is caused by JC virus. Many people have this virus in
- 337 views
- 31 Jan, 2021
- 1 location
The Natural History of Severe Viral Infections and Characterization of Immune Defects in Patients Without Known Immunocompromise
Background Infections caused by viruses are common causes of illnesses: the common cold, many ear infections, sore throats, chicken pox, and the flu are caused by different viruses. Usually, these illnesses last only few days or, at most, a few weeks. Some virus infections like influenza are cleared from the …
- 1033 views
- 17 Aug, 2021
- 1 location