Ulcerative Colitis (Pediatric) Clinical Trials

A listing of Ulcerative Colitis (Pediatric) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 95 clinical trials
Featured trial
A3921210 OVATION  

This study, A3921210 is designed to evaluate the efficacy, safety and pharmacokinetics (PK) of tofacitinib in pediatric participants with moderately to severely active UC. In the US patients with prior TNFi failure or intolerance will be enrolled. Outside of the US, TNFi naïve and TNFi experienced patients will be enrolled.All eligible participants …

cancer
mercaptopurine
pediatric ulcerative colitis
azathioprine
remission
  • 41 views
  • 12 Oct, 2022
  • 9 locations
UC Cohort - The Influence of Diet on Gut Microbiotas

The purpose of this research is to determine if different diets have different effects on the inflammation in the colon.

  • 0 views
  • 04 Oct, 2022
  • 1 location
Assessment of Empagliflozin as Adjuvant Therapy in Patients With Ulcerative Colitis

This is a randomized, controlled study evaluating empagliflozin tablets administered daily for 8 weeks. The purpose of the study is to evaluate the efficacy and safety of empagliflozin in the treatment of mild to moderately active ulcerative colitis. Disease activity will be measured using Mayo score for ulcerative colitis activity. …

immunomodulators
  • 0 views
  • 11 Nov, 2021
  • 1 location
Clinical Study of Cord Blood Mononuclear Cells on Treatment of Hormone-resistant or Hormone-dependent Ulcerative Colitis

This study conducted a systematic clinical observation of the clinical efficacy of UCB-MNCs in the treatment of hormone-resistant or hormone-dependent ulcerative colitis, in order to observe its clinical safety and efficacy.

prednisone
azathioprine
adalimumab
  • 4 views
  • 22 May, 2021
  • 1 location
Drug Repurposing - Statins as Microbiota Modulating Agents in Ulcerative Colitis

Evaluation of the microbiota modulation away from inflammation associated microbiota profile Bacteroides2 (Bact2) Evaluation of the microbiota modulation potential of statins in Bact2- enterotyped, healthy volunteers and ulcerative colitis patients. Evaluation of the effect of microbiota modulation on disease activity in ulcerative colitis patients. Evaluation of reduced inflammatory parameters of …

microbiota
remission
  • 0 views
  • 21 May, 2021
  • 2 locations
Determination of the Optimal Treatment Target in Ulcerative Colitis (VERDICT)

Disease activity and response to therapy in ulcerative colitis (UC) can be assessed by a range of endpoints including symptoms, endoscopic mucosal activity, histological disease activity, and biomarkers. This study aims to determine the optimal treatment target, which is a research priority for the management of UC both to inform …

vedolizumab
hematochezia
remission
tumor necrosis factor
corticosteroids
  • 53 views
  • 24 Apr, 2022
  • 37 locations
Study of OSE-127 vs Placebo in Patients With Moderate to Severe Active Ulcerative Colitis

This is a phase 2, multicenter, randomized, double-blind, placebo-controlled, parallel-group study in patients with moderate to severe active ulcerative colitis.

immunosuppressive agents
vedolizumab
monoclonal antibodies
hematochezia
corticosteroids
  • 0 views
  • 05 Jul, 2021
  • 55 locations
A Phase 3, Multicenter, Randomized, Double-Blind, Parallel, Placebo-Controlled Induction Study of Mirikizumab in Conventional-Failed and Biologic-Failed Patients With Moderately to Severely Active Ulcerative Colitis (LUCENT 1)

The purpose of this study is to evaluate the safety and efficacy of Mirikizumab in participants with moderately to severely active ulcerative colitis (UC) who have had an inadequate response to, loss of response, or intolerant to conventional or biologic therapy for UC.

mirikizumab
  • 1999 views
  • 15 Oct, 2022
  • 36 locations
A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of the Safety, Efficacy, and Biomarker Response of BMS-986165 in Subjects With Moderate to Severe Ulcerative Colitis

The purpose of this study is to assess the safety and tolerability, efficacy, and biomarker response of BMS-986165 administered orally in participants with moderate to severe ulcerative colitis. The study was originally designed to test deucravacitinib at two doses for 12 weeks compared to placebo. After the initial 12-Week period, …

immunomodulators
tumour necrosis
corticosteroids
tumor necrosis factor
  • 0 views
  • 16 Oct, 2022
  • 23 locations
A Randomized, Double-Blind, Placebo-Controlled, 52-Week Study to Assess the Efficacy and Safety of Etrasimod in Subjects With Moderately Active Ulcerative Colitis (GLADIATOR UC)

The purpose of this study is to determine whether oral etrasimod is a safe and effective treatment for moderately active ulcerative colitis in adult participants.

endoscopy
  • 0 views
  • 24 Oct, 2022
  • 101 locations