Glioblastoma multiforme Clinical Trials

A listing of Glioblastoma multiforme medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 48 clinical trials
Neratinib + Valproate in Advanced Solid Tumors w/Expansion Cohort in Ras-Mutated Ca

the neratinib and sodium valproate combination in advanced solid tumors with attention to RAS-mutated tumors, EGFR-altered GBM, and ocular melanoma, as part of the phase 2 expansion cohort.

renal function
solid tumour
liver metastasis
metastasis
solid tumor
  • 14 views
  • 09 Sep, 2021
  • 1 location
A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

RSC-101 is a Phase 1a/1b clinical trial of RSC-1255 in adult study participants with advanced solid tumor malignancies who are intolerant of existing therapies known to provide clinical benefit, have disease that has progressed after standard therapy, or have previously failed other therapies. The study has two phases. The purpose …

solid tumor
  • 1 views
  • 09 Sep, 2021
  • 6 locations
BGB-290 and Temozolomide in Treating Patients With Recurrent Gliomas With IDH1/2 Mutations

This phase I/II trial studies the side effects and how well BGB-290 and temozolomide work in treating patients with gliomas (brain tumors) with IDH1/2 mutations that have come back. BGB-290 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in …

alkylating agents
procarbazine
brain tumor
carcinoma in situ
temozolomide
  • 1 views
  • 17 Sep, 2021
  • 17 locations
Fluoroethyltyrosine in Detecting Tumors in Participants With Recurrent Intracranial Tumors

This phase II trial studies how well F-18 fluoroethyltyrosine (fluoroethyltyrosine) works in detecting tumors in participants with intracranial tumors that have come back. Imaging agents, such as fluoroethyltyrosine, may help doctors see the tumor better during a positron emission tomography (PET) scan.

pet scan
positron emission tomography
MRI
  • 1 views
  • 05 Sep, 2021
  • 1 location
Study of Safety and Tolerability of BCA101 Alone and in Combination With Pembrolizumab in Patients With EGFR-driven Advanced Solid Tumors

The investigational drug to be studied in this protocol, BCA101, is a first-in-class compound that targets both EGFR with TGF. Based on preclinical data, this bifunctional antibody may exert synergistic activity in patients with EGFR-driven tumors.

solid tumour
carcinoma
experimental drug
head and neck carcinoma
breast cancer
  • 7 views
  • 19 Sep, 2021
  • 6 locations
VB-111 in Combination With Nivolumab in People With Metastatic Colorectal Cancer (mCRC)

Background Gastrointestinal cancer is one of the most common cancers worldwide. Researchers think an unmet need exists to understand and improve treatment options. They want to see if a combination of drugs can help people with metastatic colorectal cancer. Objective To see if using a combination of VB-111 and nivolumab …

nivolumab
liver metastasis
metastasis
KRAS
measurable disease
  • 32 views
  • 12 Sep, 2021
  • 1 location
Collection of Blood and Urine Samples in Patients Receiving Radiation Therapy for Glioblastoma Multiforme

This study will collect blood and urine samples from patients undergoing radiation therapy for glioblastoma multiforme (a type of brain tumor) to investigate the effects of this treatment on

supratentorial glioblastoma multiforme
brain tumor
vascular endothelial growth factor
MRI
cancer
  • 18 views
  • 12 Sep, 2021
  • 1 location
A Biospecimen Collection Study in BRAF-V600E Mutated Recurrent Gliomas

This is a surgical biospecimen collection study. The purpose of this study is to understand how much of two drugs (dabrafenib and trametinib) are able to penetrate brain tumors and turn off the RAF signaling pathway. This is important because these drugs are currently FDA approved for other tumors and …

trametinib
brain tumor
dabrafenib
astrocytoma, anaplastic
anaplastic astrocytoma
  • 28 views
  • 16 Sep, 2021
  • 6 locations