Glioblastoma multiforme Clinical Trials

A listing of Glioblastoma multiforme medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 48 clinical trials
Determining Dose of Regadenoson Most Likely to Transiently Alter the Integrity of the Blood-Brain Barrier in Patients With High Grade Gliomas

enroll patients with histologically confirmed high-grade gliomas to evaluate the ability of regadenoson to transiently disrupt a relatively intact blood-brain barrier (BBB). determine the best dose of regadenoson to disrupt the BBB and allow for enhanced penetration of gadolinium during MRI.

malignant glioma
regadenoson
hydroxychloroquine
bevacizumab
vegf
  • 3 views
  • 18 Sep, 2021
  • 9 locations
T Cells Expressing HER2-specific Chimeric Antigen Receptors(CAR) for Patients With HER2-Positive CNS Tumors

This study is for patients that have brain cancer. The body has different ways of fighting infection and disease. No single way seems perfect for fighting cancers. This research study combines two different ways of fighting cancer: antibodies and T cells. Antibodies are types of proteins that protect the body …

dexamethasone
malignant brain tumor
temozolomide
growth factor
cns neoplasm
  • 28 views
  • 17 Sep, 2021
  • 2 locations
Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM AA and AOA

States each year. These highly malignant cancers remain a significant unmet clinical need in oncology. GBM often has a high expression of EFGR (Epidermal Growth Factor Receptor), which is associated with

tumor progression
malignant brain tumor
oligoastrocytoma
platelet count
aptt
  • 282 views
  • 06 Sep, 2021
  • 1 location
Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma

This phase II trial studies how well the combination of dabrafenib and trametinib works after radiation therapy in children and young adults with high grade glioma who have a genetic change called BRAF V600 mutation. Radiation therapy uses high energy rays to kill tumor cells and reduce the size of …

malignant glioma
ganglioglioma
platelet count
anticonvulsants
blood transfusion
  • 129 views
  • 19 Sep, 2021
  • 56 locations
Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG

The goal of this study is to estimate the efficacy of encorafenib and binimetinib as measured by radiographic response in recurrent high-grade primary brain tumors.

binimetinib
bevacizumab
hydroxychloroquine
vegf
cancer
  • 24 views
  • 19 Sep, 2021
  • 9 locations
Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Glioblastoma

patients with newly diagnosed MGMT unmethylated glioblastoma. Radiation therapy uses high energy photons to kill tumor and shrink tumors. Chemotherapy drugs, such as temozolomide, work in different ways to

neutrophil count
brain mri
tumor resection
flair
immunohistochemistry
  • 1 views
  • 19 Sep, 2021
  • 149 locations
[18F]DASA-23 and PET Scan in Evaluating Pyruvate Kinase M2 Expression in Patients With Intracranial Tumors or Recurrent Glioblastoma and Healthy Volunteers

recurrent glioblastoma and healthy volunteers. PKM2 regulates brain tumor metabolism, a key factor in glioblastoma growth. [18F]DASA-23 is a radioactive substance with the ability to monitor PKM2 activity

neutrophil count
platelet count
positron emission tomography
MRI
brain tumor
  • 111 views
  • 19 Sep, 2021
  • 1 location
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas

This phase I trial studies the side effects and best dose of BGB-290 and temozolomide in treating adolescents and young adults with IDH1/2-mutant grade I-IV glioma that is newly diagnosed or has come back. BGB-290 may stop the growth of tumor cells by blocking some of the enzymes needed for …

malignant glioma
IDH2
MRI Scan
platelet count
corticosteroids
  • 24 views
  • 18 Sep, 2021
  • 20 locations
Olaparib in Treating Patients With Advanced Glioma Cholangiocarcinoma or Solid Tumors With IDH1 or IDH2 Mutations

This phase II trial studies how well olaparib works in treating patients with glioma, cholangiocarcinoma, or solid tumors with IDH1 or IDH2 mutations that have spread to other places in the body (metastatic) and usually cannot be cured or controlled with treatment (refractory). Olaparib may stop the growth of tumor …

IDH2
platelet count
corticosteroids
solid tumor
hysterectomy
  • 110 views
  • 17 Sep, 2021
  • 25 locations
Feasibility and Preliminary Efficacy of a Mindfulness-based Intervention for Children and Young Adults With High Grade or High-Risk Cancer and Their Caregivers

Background People cope with cancer in different ways. Mindfulness means focusing on the present moment with an open mind. Researchers want to see if this can help children and young adults with a high-grade high-risk cancer with poor prognosis. Objective To learn if mindfulness is feasible and acceptable for children …

cancer
myeloid leukemia
lymphoid leukemia
KIT
brain tumor
  • 14 views
  • 12 Sep, 2021
  • 1 location