Colon cancer; rectal cancer Clinical Trials

A listing of Colon cancer; rectal cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 592 clinical trials
Open Label Phase 2 Study of Tisotumab Vedotin for Locally Advanced or Metastatic Disease in Solid Tumors (innovaTV 207)

This trial will study tisotumab vedotin to find out whether it is an effective treatment for certain solid tumors and what side effects (unwanted effects) may occur. There are four parts to this study. In Part A, the treatment will be given to participants every 3 weeks (3-week cycles). In …

pembrolizumab
carboplatin
solid tumour
kinase inhibitor
cancer
  • 247 views
  • 18 Sep, 2022
  • 33 locations
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation

This is a Phase I dose-escalation and dose-expansion study that will evaluate the safety, pharmacokinetics (PK), and preliminary activity of GDC-6036 in patients with advanced or metastatic solid tumors with a KRAS G12C mutation.

solid tumour
cetuximab
bevacizumab
ki-ras
erlotinib
  • 92 views
  • 27 Jul, 2022
  • 56 locations
A Phase Ib/II Open-label, Multi-center Dose Escalation Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation (KontRASt-01)

This is a phase Ib/II open label study. The escalation part will characterize the safety and tolerability of JDQ443 single agent and JDQ443 in combination with the other study treatments (TNO155 and tislelizumab) in advanced solid tumor patients. After the determination of the maximum tolerated dose / recommended dose for …

KRAS
measurable disease
solid tumor
  • 8 views
  • 16 Sep, 2022
  • 29 locations
Aspirin in Colorectal Cancer Liver Metastases (ASAC)

The ASAC trial is a Scandinavian, multi-center, double-blinded, randomized, placebo-controlled study to determine whether adjuvant treatment with low-dose acetylsalicylic acid (ASA) can improve disease free survival in patients treated with resection for colorectal cancer liver metastases (CRCLM). Several studies have shown beneficial effect of ASA on primary prevention of CRC …

liver metastasis
metastasis
primary tumor
cancer
aspirin
  • 205 views
  • 29 Apr, 2022
  • 15 locations
Pediatric Reporting of Adult-Onset Genomic Results

The Investigators will conduct a longitudinal, mixed-methods cohort study to assess primary and secondary psychosocial outcomes among 705 MyCode pediatric participants and their parents, and health behaviors of parents whose children receive an adult- or pediatric-onset genomic result. Data will be gathered via quantitative surveys using validated measures of distress, …

genetic counseling
cancer
Accepts healthy volunteers
heart disease
  • 4 views
  • 09 Mar, 2022
  • 1 location
A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001) (LIBRETTO-001)

This is an open-label, first-in-human study designed to evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary anti-tumor activity of selpercatinib (also known as LOXO-292) administered orally to participants with advanced solid tumors, including rearranged during transfection (RET)-fusion-positive solid tumors, medullary thyroid cancer (MTC) and other tumors with RET activation.

solid tumour
cancer
kidney function test
RET
measurable disease
  • 1278 views
  • 10 Aug, 2022
  • 86 locations
Clinical Outcomes of NOSES Versus Traditional Robotic-assisted Surgery for Patients With Colorectal Cancer (NOTR)

In this study, the investigators will compare the clinical outcomes of the natural orifice specimen extraction surgery versus traditional robotic-assisted surgery in the treatment of colorectal cancer.

adenocarcinoma
primary cancer
colorectal adenocarcinoma
metastasis
  • 0 views
  • 23 Feb, 2022
  • 7 locations
Clinical Database of Colorectal Robotic Surgery (ROBOT CR)

Evaluation of robot Da Vinci Xi by determining its learning curve.The operating time will be defined by patient then the operating average will be calculated.

colitis
ulceration
cancer
colectomy
crohn's disease
  • 1 views
  • 12 Feb, 2022
  • 4 locations
The Cancer of the Pancreas Screening-5 CAPS5)Study (CAPS5)

Johns Hopkins clinical research office quality assurance group will monitor and audit this study at Johns Hopkins. The Sub Investigator at each site will be responsible for internal monitoring at their site.

palb2
cancer
BRCA2
ca19-9
fammm
  • 185 views
  • 21 Jul, 2022
  • 8 locations
Gevokizumab With Standard of Care Anti-cancer Therapies for Metastatic Colorectal, Gastroesophageal, and Renal Cancers

This study will determine the pharmacodynamically-active dose of gevokizumab and the tolerable dose of gevokizumab in combination with the standard of care anti-cancer therapy in patients with metastatic colorectal cancer, metastatic gastroesophageal cancer and metastatic renal cell carcinoma, and the preliminary efficacy of gevokizumab in combination with the SOC anti-cancer …

folfiri regimen
metastatic colorectal cancer
measurable disease
modified folfox6 regimen
metastatic cancer
  • 122 views
  • 19 Jun, 2022
  • 9 locations