Colon cancer; rectal cancer Clinical Trials

A listing of Colon cancer; rectal cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 68 clinical trials
A Phase IV Study to Investigate the Safety and Efficacy of Regorafenib in Indian Patients With Metastatic Colorectal Cancer (mCRC).

This is a Phase IV, single-arm, prospective, open-label, multicenter, interventional study to evaluate safety and efficacy of regorafenib in patients with mCRC who have been previously treated with fluoropyrimidine , oxaliplatin-, and irinotecan based chemotherapy, an anti-VEGF therapy, and, if RAS wild type, an anti-EGFR therapy.

bevacizumab
irinotecan
EGFR
oxaliplatin
fluoropyrimidine
  • 379 views
  • 22 Sep, 2022
  • 11 locations
Comparison of D2 vs D3 Lymph Node Dissection for Right Colon Cancer (RICON)

Comparing different method of surgical technique D2 lymph node dissection vs D3 for right colon cancer.

transverse colon cancer
hemicolectomy
adenocarcinoma
  • 68 views
  • 19 Aug, 2022
  • 1 location
Neoadjuvant Immunotherapy in Rectal Cancer: A Pilot Study Examining the Safety and Feasibility of PD-1 Blockade in the Treatment of dMMR or MSI-H Rectal Cancer

Colorectal cancer is the third most common cancer worldwide and the second leading cause of cancer mortality in the United States. The current standard of care (SOC) for locally advanced rectal cancer includes neoadjuvant chemotherapy and radiation followed by surgery. However, great variability exists in patient's response to neoadjuvant chemoradiotherapy …

adenocarcinoma of rectum
neutrophil count
rectal carcinoma
curative surgery
capecitabine
  • 0 views
  • 16 Sep, 2022
  • 1 location
Phase II Study to Assess the Safety of Non-operative Management for Low Rectal Cancer (NOM)

This is a 5 year Phase II study to evaluate the safety of non-operative management (NOM) in patients with low rectal cancer (LRC) who achieve a complete clinical response (cCR) following chemoradiotherapy (CRT). The safety of NOM will be evaluated by assessing (i) rate of local re-growth and (ii) rate …

capecitabine
rectal carcinoma
fluorouracil
chemoradiotherapy
cancer
  • 6 views
  • 21 Sep, 2022
  • 1 location
A Phase 1/2a Study to Evaluate the Dose, Safety and Tolerability and Efficacy of an Intraperitoneal α-emitting Radionuclide Therapy (Radspherin®) in Subjects With Peritoneal Carcinomatosis From Colorectal Carcinoma Following Hyperthermic Intraperitoneal Chemotherapy

This is a phase 1/2a open label study to evaluate the dose, safety, tolerability and efficacy of an IP α-emitting radionuclide therapy (Radspherin®) in subjects with peritoneal carcinomatosis (PC) from colorectal carcinoma following complete CRS (cytoreduction score CC-0) and HIPEC. The study consists of three different cohorts: Dose escalation cohorts …

metastasis
carcinoma
hyperthermic intraperitoneal chemotherapy
neutrophil count
  • 0 views
  • 21 Sep, 2022
  • 2 locations
PAnitumumab REchallenge Followed by REgorafenib Versus the Reverse Sequence (PARERE)

The association of doublet chemotherapy (FOLFOX and FOLFIRI) and anti-EGFR-moAbs (panitumumab or cetuximab) is a standard option for the first-line treatment of unresectable RAS and BRAF wt mCRC patients, especially with left-sided primary tumour. In RAS wt mCRC patients refractory to chemotherapy and anti-EGFR naive, the standard treatment sequence is …

  • 0 views
  • 09 Aug, 2022
  • 1 location
Phase Ib/II Study of TAS-102 Plus Radiation Therapy for the Treatment of the Liver in Patients With Hepatic Metastases From Colorectal Cancer

This research study is studying a drug in combination with radiation therapy as a possible treatment for hepatic metastases from colorectal cancer. The interventions involved in this study are: Trifluridine (TAS-102) Radiation Therapy

measurable disease
liver metastasis
tas-102
metastasis
neutrophil count
  • 27 views
  • 14 Sep, 2022
Diet Modulation of Bacterial Sulfur and Bile Acid Metabolism and Colon Cancer Risk

Determine in the context of a controlled crossover diet-intervention trial the role of taurocholic acid metabolism by gut bacteria in African American subjects at elevated risk for colorectal cancer (CRC). Two isocaloric diets, an animal-based diet high in taurine and saturated fat (HT-HSAT) and a plant-based, low in taurine and …

Accepts healthy volunteers
colon cancer
  • 4 views
  • 19 Sep, 2022
  • 1 location
A Phase I, Open-Label, Dose-Escalation Study Of The Safety And Pharmacokinetics Of BLYG8824A Administered Intravenously In Patients With Locally Advanced Or Metastatic Colorectal Cancer

This study will evaluate the safety, tolerability, and pharmacokinetics of BLYG8824A and will make a preliminary assessment of the anti-tumor activity of BLYG8824A in patients with locally advanced or metastatic colorectal cancer.

solid tumour
measurable disease
irinotecan
monoclonal antibodies
oxaliplatin
  • 5 views
  • 21 Sep, 2022
  • 6 locations
Phase II Trial of Combination Immunotherapy in Subjects With Advanced Small Bowel and Colorectal Cancers

Background Metastatic or refractory/recurrent small bowel and colorectal cancers cannot be cured and are often not helped by standard treatments. Researchers want to find better treatments by testing a combination of drugs. Objective To learn if a new combination of immunotherapy drugs can shrink tumors in people with advanced small …

measurable disease
liver metastasis
systemic therapy
adenocarcinoma
colorectal adenocarcinoma
  • 0 views
  • 19 Sep, 2022
  • 1 location