Colon cancer; rectal cancer Clinical Trials

A listing of Colon cancer; rectal cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 115 clinical trials
Short-term Outcomes of Full Bowel Preparation (MBP+OA) for Rectal Resections for Cancer Versus MBP Alone (REPCA)

The purpose of the study is to determine if short-term outcomes of rectal resections after full bowel preparation (mechanical bowel preparation plus oral antibiotics) are superior to rectal resections with only mechanical bowel preparation.

adenocarcinoma
proctectomy
  • 1 views
  • 18 Oct, 2022
  • 7 locations
Preoperative FOLFOX Versus Postoperative Risk-adapted Chemotherapy in Patients With Locally Advanced Rectal Cancer

This is a multicenter, prospective, randomized, stratified, controlled, open-label study comparing preoperative FOLFOX versus postoperative risk-adapted chemotherapy in patients with locally advanced rectal cancer and low risk for local failure

xelox
folfox regimen
capecitabine
adenocarcinoma
oxaliplatin
  • 0 views
  • 04 Oct, 2022
  • 1 location
IRinotecan and Oxaliplatin for Colon Cancer in Adjuvant Setting (IROCAS)

The trial is a phase III, multicenter, open-labeled randomized trial comparing the association 5-fluorouracil (5-FU), folinic acid, irinotecan and oxaliplatin (mFOLFIRINOX) versus oxaliplatin, folinic acid, 5-FU (mFOLFOX 6) chemotherapy protocols in patients with high-risk stage III colon cancer in the adjuvant setting.

  • 116 views
  • 04 Oct, 2022
  • 8 locations
Neoadjuvant FOLFOX Chemotherapy for Patients With Locally Advanced Colon Cancer

The main cause of recurrence after surgical treatment of colon cancer is distant metastasis. Neoadjuvant chemotherapy has potential benefits of improving the effectiveness of chemotherapy. Preoperative chemotherapy may eradicate microscopic metastatic cancer cells earlier than adjuvant chemotherapy, reduce cancer cell spillage during surgery, and lessen the invasiveness of surgical resection. …

folfox regimen
adjuvant chemotherapy
platelet count
adenocarcinoma
adenocarcinoma of colon
  • 1 views
  • 07 Oct, 2022
  • 4 locations
S0820, Adenoma and Second Primary Prevention Trial (PACES)

The investigators hypothesize that the combination of eflornithine and sulindac will be effective in reducing a three-year event rate of adenomas and second primary colorectal cancers in patients previously treated for Stages 0 through III colon or rectal cancer.

aspirin
adenoma
unstable angina
rectal carcinoma
anticoagulants
  • 2953 views
  • 04 Oct, 2022
  • 408 locations
Scaling CRC Screening Through Outreach, Referral, and Engagement (SCORE) (SCORE)

This study will test the effectiveness of mailing fecal immunochemical tests (FITs) in increasing colorectal cancer (CRC) screening rates in U.S. adults ages 45-75. We are implementing this study in two age groups, 45-49 years and 50-75 years.

adenoma
fecal immunochemical test
Accepts healthy volunteers
blood test
  • 0 views
  • 07 Oct, 2022
  • 1 location
Comparative Effectiveness of Split-Dose Colonoscopy Bowel Preparation Regimens

From the patients' perspective, the most formidable part of the colonoscopy experience is the process of bowel cleansing. A poorly tolerated bowel preparation regimen often leads to incompletion of scheduled colonoscopies which in turn undermines the effectiveness of colonoscopy, increases cost, and decreases patient satisfaction. The current standard bowel preparation …

bowel preparation
  • 63 views
  • 13 Oct, 2022
  • 1 location
Effect of EPA-FFA on Polypectomy in Familial Adenomatous Polyposis

2 Year randomised, double-blind, placebo-controlled, parallel group study to determine the safety and efficacy of EPA-FFA gastro resistant capsules in FAP.

colectomy
eicosapentaenoic acid
rectal anastomosis
aspirin
  • 5 views
  • 04 Oct, 2022
  • 11 locations
Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors (innovaTV 207)

This trial will study tisotumab vedotin to find out whether it is an effective treatment for certain solid tumors and what side effects (unwanted effects) may occur. There are four parts to this study. In Part A, the treatment will be given to participants every 3 weeks (3-week cycles). In …

cancer
systemic therapy
adenocarcinoma
oxaliplatin
carboplatin
  • 247 views
  • 07 Oct, 2022
  • 33 locations
A Phase Ib/II Open-label, Multi-center Dose Escalation Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation (KontRASt-01)

This is a phase Ib/II open label study. The escalation part will characterize the safety and tolerability of JDQ443 single agent and JDQ443 in combination with the other study treatments (TNO155 and tislelizumab) in advanced solid tumor patients. After the determination of the maximum tolerated dose / recommended dose for …

KRAS
measurable disease
solid tumor
  • 8 views
  • 22 Oct, 2022
  • 29 locations