Acute Myelogenous Leukemia (AML) Clinical Trials

A listing of Acute Myelogenous Leukemia (AML) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 531 clinical trials
Idarubicin Plus Cytarabine (IA) vs IA Plus Cladribine (IAC) as Induction Regimen to Treat Initially Diagnosed Acute Myeloid Leukemia (AML)

The purpose of this study is to compare the clinical efficacy and safety of IAC regimen and IA regimen as induction chemotherapy for initial diagnosed AML patients. 840 cases are supposed to recruited in 3 years.

cytarabine
ara-c
induction chemotherapy
cladribine
idarubicin
  • 26 views
  • 24 Jan, 2021
  • 1 location
HDM201 in Combination With MBG453 or Venetoclax in Patients With Acute Myeloid Leukemia (AML) or High-risk Myelodysplastic Syndrome (MDS)

This is a phase 1b, multi-arm, open-label study of HDM201 in combination with MBG453 or venetoclax in subjects with AML or high-risk MDS. For all subjects, TP53wt status must be characterized by, at a minimum, no mutations noted in exons 5, 6, 7 and 8. Two treatment arms will enroll …

cytarabine
induction chemotherapy
cell transplantation
venetoclax
TP53
  • 51 views
  • 14 May, 2021
  • 10 locations
Safety and Effectiveness of Quizartinib in Children and Young Adults With Acute Myeloid Leukemia (AML) a Cancer of the Blood

Quizartinib is an experimental drug. It is not approved for regular use. It can only be used in medical research. Children or young adults with a certain kind of blood cancer (FLT3-ITD AML) might be able to join this study if it has come back after remission or is not …

cytarabine
blast cells
cancer
remission
induction chemotherapy
  • 39 views
  • 15 Apr, 2021
  • 39 locations
Safety Tolerability PK PD and Efficacy of AMG 427 in Subjects With Relapsed/Refractory Acute Myeloid Leukemia

Evaluate the safety and tolerability of AMG 427 in adult subjects with relapsed/refractory AML. Estimate the maximum tolerated dose (MTD) and / or a biologically optimal dose (eg, recommended phase 2 dose [RP2D]).

  • 10 views
  • 16 Jun, 2021
  • 23 locations
Comparison Between Two Dose Levels of Daunorubicin and Between One vs. Two Induction Cycles for Adult Patients With AML

The proposed trial will address two clinically important questions for younger patients with newly diagnosed acute myeloid leukemia (AML): the optimal dose of daunorubicin in induction therapy

daunorubicin
acute promyelocytic leukemia
blast cells
neoadjuvant therapy
minimal residual disease
  • 33 views
  • 24 Jan, 2021
  • 41 locations
A Safety and Efficacy Study of CC-90009 Combinations in Subjects With Acute Myeloid Leukemia

CC-90009-AML-002 is an exploratory Phase 1b open-label multi-arm trial to evaluate the safety and efficacy of CC-90009 in combination with anti-leukemia agents in subjects with acute myeloid

flt3 internal tandem duplication
venetoclax
refractory acute myeloid leukemia (aml)
hydroxyurea
azacitidine
  • 12 views
  • 26 May, 2021
  • 14 locations
Treatment Study for Children and Adolescents With Acute Promyelocytic Leukemia

The trial is open to all patients with a diagnosis of acute promyelocytic leukemia (APL) who are PCR-positive for the PML-RAR transcript and less than 18 years of age.

  • 0 views
  • 21 Mar, 2021
  • 29 locations
Study for Patients With Newly Diagnosed High-risk Acute Promyelocytic Leukemia

Acute promyelocytic leukemia (APL) is a rare subtype of acute myeloid leukemia (AML) characterized by consistent clinical, morphologic, and genetic features. According to the FAB classification

monoclonal antibody
secondary mds
acute promyelocytic leukemia
anthracyclines
cytarabine
  • 0 views
  • 23 Jan, 2021
  • 8 locations
AIDA 2000 Guidelines

Prospective use of RT-PCR for PML/RARa might be used to guide a total tehrapy approach in APL, including refined diagnosis, front-line treatment, assessment of response and anticipated salvage therapy for patients who undergo molecular relapse.

serum bilirubin level
tretinoin
serum bilirubin
  • 36 views
  • 25 Jan, 2021
  • 3 locations
The Role of Ruxolitinib in Secondary Acute Myelogenous Leukemia Evolving From Myeloproliferative Neoplasm

This trial aimed to investigate the therapeutic efficacy of ruxolitinib in combination with cytotoxic chemotherapy for post-myeloproliferative neoplasm secondary acute myeloid leukemia.

  • 1 views
  • 24 Jan, 2021
  • 2 locations