Heart Defect Clinical Trials

A listing of Heart Defect medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 231 clinical trials
Remotely Monitored and Coached Cardiac Rehabilitation Northern Sweden

Supervised exercise is an essential component of contemporary center-based cardiac rehabilitation (CR) programs. Despite the proven effectiveness, uptake and adherence to supervised exercise-based CR (exCR) remains suboptimal (approximately 50%), especially in rural and remote areas of Sweden. The main reasons for low participation rate in centre-based exCR are different accessibility …

heart surgery
cardiac rehabilitation
  • 26 Jan, 2021
  • 1 location
Evaluation of Lomecel-B Injection in Patients With Hypoplastic Left Heart Syndrome: A Phase IIb Clinical Trial.

The purpose of this study is to test whether Lomecel-B works in treating patients with hypoplastic left heart syndrome (HLHS) and to gather additional information about the safety of Lomecel-B. Lomecel-B contains human mesenchymal stem cells (MSCs) as the active ingredient. MSCs are special cells in the body that are …

  • 07 Aug, 2021
  • 7 locations
Mutation-specific Therapy for the Long QT Syndrome

Novel therapy for the Long QT Syndrome based on the mechanism of action of the disease-causing mutations Long QT syndrome type 2 (LQT2) accounts for ~ 35% of all LQTS cases and is difficult to manage, as beta-blockers frequently fail to provide full protection. Most LQT2 patients (pts) have a …

heart failure
electrocardiographic monitoring
  • 01 Sep, 2021
  • 1 location
Mesoblast Stem Cell Therapy for Patients With Single Ventricle and Borderline Left Ventricle

Patients under the age of 5, with a diagnosis of hypoplastic left heart syndrome (HLHS), unbalanced atrioventricular canal (uAVC), or borderline left heart who are undergoing staged LV recruitment following bidirectional Glenn (BDG) or undergoing BDG with plans for LV recruitment will be considered for enrollment in this study. Those …

single ventricle
  • 25 Jan, 2021
Safety of Autologous Cord Blood Cells in HLHS Patients During Norwood Heart Surgery

This study aims to evaluate the safety and feasibility of coronary infusion of autologous placental cord blood mononuclear cells during the Norwood heart operation in newborn hypoplastic left heart syndrome (HLHS) patients.

heart surgery
hypoplastic left heart syndrome
  • 25 Jan, 2021
  • 1 location
Maternal Hyperoxygenation in Congenital Heart Disease

A pilot study investigating the safety and feasibility of chronic maternal hyperoxygenation in the setting of fetal congenital heart disease

heart disease
  • 19 Apr, 2021
  • 1 location
Intramyocardial Injection of Autologous Umbilical Cord Blood Derived Mononuclear Cells During Surgical Repair of Hypoplastic Left Heart Syndrome

Researchers want to better understand what happens to the heart when the stem cells are injected directly into the muscle of the right side of the heart during the Stage II palliative surgery for single ventricle patients with hypoplastic left heart syndrome (HLHS) or HLHS variant. Researchers want to see …

single ventricle
  • 27 May, 2021
  • 10 locations
Cold Heart Study: A Randomized Pilot Trial of Surfactant Therapy

This clinical trial is being done to see if giving surfactant (Curosurf) will decrease the number of days that infants will need a breathing tube, decrease the days in the critical care unit and decrease the number of days needed in the hospital. The primary hypothesis for this study is …

hypoplastic left heart syndrome
  • 07 May, 2021
  • 1 location
The CHILD Trial: Hypoplastic Left Heart Syndrome Study.

The objectives of this pilot study are to evaluate the feasibility and safety of intramyocardial injection of autologous c-kit+ cells during the Stage II BDCPA operation and to observe effects on clinical outcome including right ventricular myocardial function, severity of tricuspid regurgitation, incidence of serious adverse events, re-hospitalizations, changes in …

heart failure
  • 13 Apr, 2021
  • 3 locations
Paracetamol And Ibuprofen/Indomethacin in Closing Patent Ductus Arteriosus

The purpose of this pilot trial is to study efficacy and safety of simultaneous intravenous (iv) ibuprofen/indomethacin and paracetamol medications in the closure of patent ductus arteriosus (PDA) in preterm infants. It is randomized, placebo-controlled, double-blind, phase 1, multicenter, clinical trial.

closure of patent ductus arteriosus
  • 16 May, 2021
  • 4 locations