Heart Defect Clinical Trials

A listing of Heart Defect medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 231 clinical trials
Evaluation of Aortic Stiffness as a Prognostic Indicator of Aortic Dilatation in Patients With Bicuspid Aortic Valve by Multimodal Imaging

The objective is the development and validation of morphological markers informative of aortic dilatation in order to improve the precision of the risk of aneurysm of the thoracic aorta and of acute aortic syndrome for patients with bicuspid aortic valve (BAV). The primary objective of this study is to demonstrate …

  • 28 Jan, 2021
  • 1 location
ARNI in Asymptomatic Patients With Elevated Natriuretic Peptide and Elevated Left Atrial Volume Index eLEvation

The purpose of this study is to determine whether LCZ696 (valsartan/sacubitril) is safe and has beneficial effects on the heart and blood vessels in patients with high blood pressure and/or diabetes or other risk factors for developing heart failure (elevated levels of natriuretic peptide and elevated left atrial volume index). …

heart failure
natriuretic peptide
  • 08 Nov, 2020
  • 1 location
Interval Training in Heart Failure

Heart failure (HF) is currently considered a common pathology, with 15 million adults in Europe and 26 million worldwide. The American Heart Association (AHA) estimates that their number will increase by 25% by 2030. In France, HF affects more than one million people. Because of the repeated hospitalizations of this …

cardiac rehabilitation
systolic heart failure
  • 20 Jul, 2021
  • 1 location
Efficacy and Safety of Odevixibat in Patients With Alagille Syndrome

Double-blind, randomized, placebo-controlled, Phase 3 study to investigate the efficacy and safety of odevixibat compared to placebo in Patients with Alagille Syndrome.

  • 22 Sep, 2021
  • 18 locations
Cardiac Operation Under Totally Endoscope and Cardiopulmonary Bypass (CPB)

Conventional cardiac operations are performed with median sternotomy, which is related to great wound, morbidities, longer duration in hospital and most significantly, cosmetic problems. The investigators invested a new minimally invasive cardiac operation method totally under video-endoscope and peripheral cardiopulmonary bypass. The investigators' hypothesis is that this new minimally method …

congenital heart defects
heart surgery
valvular disease
cardiopulmonary bypass
  • 07 Nov, 2020
  • 1 location
Umbilical Cord Blood Collection and Processing for Hypoplastic Left Heart Syndrome Patients

Cell-based cardiac regeneration has been the focus of acquired, adult heart disease for many years. However, congenital heart disease with severe structural abnormalities may also be reasonable targets for cell-based therapies. Interestingly, the pediatric heart is naturally growing and may be the most amendable to regenerative strategies. Therefore, identifying autologous …

  • 23 Jun, 2021
  • 3 locations
Management of the PDA Trial

Estimate the risks and benefits of active treatment versus expectant management of a symptomatic patent ductus arteriosus (sPDA) in premature infants.

preterm birth
active treatment
  • 24 Jan, 2021
  • 16 locations
A Study to Evaluate the Safety and Tolerability of Maralixibat in Infant Participants With Cholestatic Liver Diseases Including Progressive Familial Intrahepatic Cholestasis (PFIC) and Alagille Syndrome (ALGS).

This study is designed to assess whether the investigational drug maralixibat, is safe and well tolerated in children <12 months of age with Alagille Syndrome [ALGS] or Progressive Familial Intrahepatic Cholestasis [PFIC].

  • 23 Sep, 2021
  • 6 locations
Cardiovascular Response to Maternal Hyperoxygenation in Fetal Congenital Heart Disease

Cardiovascular Response to Maternal Hyperoxygenation in Fetal Congenital Heart Disease

heart disease
fetal echocardiography
  • 22 Jan, 2021
  • 1 location
Nitric Oxide During Bypass for Arterial Switch Operation

This trial will test if adding nitric oxide (NO) gas to the cardiopulmonary bypass (CPB) circuit in infants undergoing an arterial switch operation (ASO) for Transposition of the Great Arteries (TGA) changes the incidence of major postoperative adverse events (AEs). Major postoperative AEs include cardiac arrest, emergency chest opening, use …

  • 03 Jul, 2021
  • 7 locations