Heart Defect Clinical Trials

A listing of Heart Defect medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 87 clinical trials
Study of Sotatercept in Newly Diagnosed Intermediate- and High-risk PAH Patients (HYPERION)

The objective of this study is to evaluate the effects of sotatercept treatment (plus background PAH therapy) versus placebo (plus background PAH therapy) on time to clinical worsening (TTCW) in participants who are newly diagnosed with PAH and are at intermediate or high risk of disease progression.

  • 13 Jul, 2022
  • 76 locations
A Study of Sotatercept in Participants With PAH WHO FC III or FC IV at High Risk of Mortality (MK-7962-006/ZENITH) (ZENITH)

The objective of this study is to evaluate the effects of sotatercept (MK-7962, formerly called ACE-011) treatment (plus maximum tolerated background pulmonary arterial hypertension (PAH) therapy) versus placebo (plus maximum tolerated background PAH therapy) on time to first event of all cause death, lung transplantation, or PAH worsening-related hospitalization of …

  • 10 Aug, 2022
  • 38 locations
ATC Vs PSV for Ventilatory Weaning of Pediatrics Postcardiac Surgery

, endotracheal tube, and airways. The aim of the study is to evaluate the automatic tube compensation (ATC) as a tool for ventilatory weaning in pediatrics after surgeries for congenital cardiac anomalies.

  • 18 May, 2022
  • 1 location
Evaluation of Aortic Stiffness as a Prognostic Indicator of Aortic Dilatation in Patients With Bicuspid Aortic Valve by Multimodal Imaging (IRM-BAO)

The objective is the development and validation of morphological markers informative of aortic dilatation in order to improve the precision of the risk of aneurysm of the thoracic aorta and of acute aortic syndrome for patients with bicuspid aortic valve (BAV). The primary objective of this study is to demonstrate …

  • 07 Apr, 2022
  • 1 location
Interval Training in Heart Failure (PROVO2MAX)

Heart failure (HF) is currently considered a common pathology, with 15 million adults in Europe and 26 million worldwide. The American Heart Association (AHA) estimates that their number will increase by 25% by 2030. In France, HF affects more than one million people. Because of the repeated hospitalizations of this …

cardiac rehabilitation
systolic heart failure
  • 05 Jul, 2022
  • 1 location
8-Weeks of High-Intensity Interval Training or Concurrent Training in Overweight and Obese Adult Males

Overweight and obesity is becoming increasingly prevalent, constituting 64% of all adults in England, causing an incessant rise in cost to the National Health Service. Exercise and physical activity have the potential to reduce incidence of overweight and obesity, as well as improve obesity-related ill health. However, overweight and obese …

Accepts healthy volunteers
  • 16 May, 2022
  • 1 location
Umbilical Cord Blood Collection and Processing for Hypoplastic Left Heart Syndrome Patients

Cell-based cardiac regeneration has been the focus of acquired, adult heart disease for many years. However, congenital heart disease with severe structural abnormalities may also be reasonable targets for cell-based therapies. Interestingly, the pediatric heart is naturally growing and may be the most amendable to regenerative strategies. Therefore, identifying autologous …

  • 07 Jul, 2022
  • 2 locations
A Study to Evaluate the Safety and Tolerability of Maralixibat in Infant Participants With Cholestatic Liver Diseases Including Progressive Familial Intrahepatic Cholestasis (PFIC) and Alagille Syndrome (ALGS). (RISE)

This study is designed to assess whether the investigational drug maralixibat, is safe and well tolerated in children <12 months of age with Alagille Syndrome [ALGS] or Progressive Familial Intrahepatic Cholestasis [PFIC].

  • 20 Jul, 2022
  • 12 locations
Respiratory and Physical Therapy in Patients With Associated Pulmonary Arterial Hypertension (APAH) With Congenital Heart Defects

patients with severe associated pulmonary arterial hypertension (APAH) as part of a congenital heart defect with / without Eisenmenger's Syndrome

congenital heart defects
  • 21 Jul, 2022
  • 1 location
The Transitioning Rural Adolescents to Adult Care Study (TRAAC)

Approximately 1 in 10 teenagers lives with a chronic health condition that will require ongoing care as they enter adulthood. Birth defects of the heart, also known as congenital heart disease (CHD) are more common than any other type of birth defect and affect about 1 in 100 children, with …

  • 07 Jun, 2022
  • 1 location