Heart Defect Clinical Trials

A listing of Heart Defect medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 11 clinical trials
A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (STELLAR)

The objectives of this study are to evaluate the efficacy and safety of sotatercept treatment (plus background PAH therapy) versus placebo (plus background PAH therapy) at 24 weeks in adults with PAH.

  • 28 Jul, 2021
  • 29 locations
Interval Training in Heart Failure

Heart failure (HF) is currently considered a common pathology, with 15 million adults in Europe and 26 million worldwide. The American Heart Association (AHA) estimates that their number will increase by 25% by 2030. In France, HF affects more than one million people. Because of the repeated hospitalizations of this …

systolic heart failure
cardiac rehabilitation
  • 20 Jul, 2021
  • 1 location
Efficacy and Safety of Odevixibat in Patients With Alagille Syndrome

Double-blind, randomized, placebo-controlled, Phase 3 study to investigate the efficacy and safety of odevixibat compared to placebo in Patients with Alagille Syndrome.

  • 28 Jul, 2021
  • 11 locations
A Study to Evaluate the Safety and Tolerability of Maralixibat in Infant Participants With Cholestatic Liver Diseases Including Progressive Familial Intrahepatic Cholestasis (PFIC) and Alagille Syndrome (ALGS).

This study is designed to assess whether the investigational drug maralixibat, is safe and well tolerated in children <12 months of age with cholestatic liver disease (Alagille Syndrome [ALGS] or Progressive Familial Intrahepatic Cholestasis [PFIC]).

  • 21 Jul, 2021
  • 6 locations
Assessing the Role of Cariprazine in Improving Cognition in Euthymic Bipolar Patients

Some patients with bipolar disorder show broad cognitive impairments (e.g. difficulty with concentration, problem solving, memory etc.) that persist during euthymia (no symptoms of depression or mania) despite remission of mood symptoms. Cognitive deficits (significant cognitive impairments) in bipolar disorder are associated with impairments in everyday functioning and quality of …

  • 19 Jul, 2021
  • 2 locations
Early Prediction of Spontaneous Patent Ductus Arteriosus (PDA) Closure and PDA-Associated Outcomes

Patent ductus arteriosus (PDA), very common in preterm infants, is the delayed closure of a fetal blood vessel that limits blood flow through the lungs. PDA is associated with mortality and harmful long term outcomes including chronic lung disease and neurodevelopmental delay. Although, treatments to close PDA likely benefit some …

pulmonary disease
patent ductus arteriosus
chronic lung disease
  • 31 Jul, 2021
  • 4 locations
Gonadal Tissue Freezing for Fertility Preservation in Girls at Risk for Ovarian Dysfunction and Premature Ovarian Insufficiency

This study is evaluating ovarian tissue cryopreservation in female children with Turner syndrome and galactosemia as well as post-menarcheal adolescents with recent premature ovarian insufficiency. Given the great importance of fertility to patients and their parents and the significant negative quality of life effects of infertility, there is strong interest …

ovarian failure
  • 29 Jul, 2021
  • 1 location
Clinical Genetic and Epidemiologic Study of Children and Adults With RASopathies

Background The RASopathies are a clinically defined group of disorders caused by germline mutations in genes encoding components of the Ras/mitogen-activated-protein kinase (Ras/MAPK) pathway. These disorders have overlapping clinical features due to Ras/MAPK dysfunction, including a predisposition to the development of certain malignancies. The aims of this prospective longitudinal cohort …

  • 29 Jul, 2021
  • 1 location
Efficacy of Three Dimensional Transesophageal Echocardiography for Percutaneous Device Closure in Atrial Septal Defect

Background: Three-dimensional echocardiographic image for atrial septal defect (ASD) is useful for evaluation of defect size and shape. The investigators suggested optimal device size using three-dimensional transesophageal echocardiographic image and our formula in previous study. Purpose: In this study, the investigators seek to predict the correct device size and confirm …

three dimensional transesophageal echocardiography
transesophageal echocardiography
closure of atrial septal defect
  • 29 Jul, 2021
  • 1 location
GORE CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

This study will assess the safety and effectiveness of GORE CARDIOFORM Septal Occluder in a post approval setting and evaluate the quality of operator education and training and transferability of trial experience to a post-market setting.

transcranial doppler
closure of patent foramen ovale
ischemic stroke
transesophageal echocardiography
  • 19 Jul, 2021
  • 40 locations