Heart Defect Clinical Trials

A listing of Heart Defect medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 197 clinical trials
Study of Sotatercept in Newly Diagnosed Intermediate- and High-risk PAH Patients (HYPERION)

The objective of this study is to evaluate the effects of sotatercept treatment (plus background PAH therapy) versus placebo (plus background PAH therapy) on time to clinical worsening (TTCW) in participants who are newly diagnosed with PAH and are at intermediate or high risk of disease progression.

  • 13 Jul, 2022
  • 76 locations
A Study of Sotatercept in Participants With PAH WHO FC III or FC IV at High Risk of Mortality (MK-7962-006/ZENITH) (ZENITH)

The objective of this study is to evaluate the effects of sotatercept (MK-7962, formerly called ACE-011) treatment (plus maximum tolerated background pulmonary arterial hypertension (PAH) therapy) versus placebo (plus maximum tolerated background PAH therapy) on time to first event of all cause death, lung transplantation, or PAH worsening-related hospitalization of …

  • 23 Jul, 2022
  • 36 locations
  • 25 Mar, 2021
  • 1 location
ATC Vs PSV for Ventilatory Weaning of Pediatrics Postcardiac Surgery

, endotracheal tube, and airways. The aim of the study is to evaluate the automatic tube compensation (ATC) as a tool for ventilatory weaning in pediatrics after surgeries for congenital cardiac anomalies.

  • 18 May, 2022
  • 1 location
Evaluation of Aortic Stiffness as a Prognostic Indicator of Aortic Dilatation in Patients With Bicuspid Aortic Valve by Multimodal Imaging (IRM-BAO)

The objective is the development and validation of morphological markers informative of aortic dilatation in order to improve the precision of the risk of aneurysm of the thoracic aorta and of acute aortic syndrome for patients with bicuspid aortic valve (BAV). The primary objective of this study is to demonstrate …

  • 07 Apr, 2022
  • 1 location
ARNI in Asymptomatic Patients With Elevated Natriuretic Peptide and Elevated Left Atrial Volume Index eLEvation

The purpose of this study is to determine whether LCZ696 (valsartan/sacubitril) is safe and has beneficial effects on the heart and blood vessels in patients with high blood pressure and/or diabetes or other risk factors for developing heart failure (elevated levels of natriuretic peptide and elevated left atrial volume index). …

heart failure
  • 08 Nov, 2020
  • 1 location
Interval Training in Heart Failure (PROVO2MAX)

Heart failure (HF) is currently considered a common pathology, with 15 million adults in Europe and 26 million worldwide. The American Heart Association (AHA) estimates that their number will increase by 25% by 2030. In France, HF affects more than one million people. Because of the repeated hospitalizations of this …

systolic heart failure
cardiac rehabilitation
  • 05 Jul, 2022
  • 1 location
8-Weeks of High-Intensity Interval Training or Concurrent Training in Overweight and Obese Adult Males

Overweight and obesity is becoming increasingly prevalent, constituting 64% of all adults in England, causing an incessant rise in cost to the National Health Service. Exercise and physical activity have the potential to reduce incidence of overweight and obesity, as well as improve obesity-related ill health. However, overweight and obese …

Accepts healthy volunteers
  • 16 May, 2022
  • 1 location
Congenital Heart Anomaly Risk in Maternal Enteroviral Infection and Diabetes

Beyond EV-B, there are clinical observations to implicate other viruses in birth defects, including CHD. Since the Rubella epidemic of 1960s', however, viruses have received little attention and certainly no comprehensive study, especially using next generation sequencing (NGS), has been undertaken in this context. The current pandemic as well as …

  • 23 Aug, 2021
  • 2 locations
Umbilical Cord Blood Collection and Processing for Hypoplastic Left Heart Syndrome Patients

Cell-based cardiac regeneration has been the focus of acquired, adult heart disease for many years. However, congenital heart disease with severe structural abnormalities may also be reasonable targets for cell-based therapies. Interestingly, the pediatric heart is naturally growing and may be the most amendable to regenerative strategies. Therefore, identifying autologous …

  • 07 Jul, 2022
  • 2 locations