Esophageal Disorders Clinical Trials

A listing of Esophageal Disorders medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 45 clinical trials
Association of Radiochemotherapy and Immunotherapy for the Treatment of Unresectable Oesophageal caNcer (ARION)

This study aims to assess the efficacy of durvalumab in combination with radiochemotherapy (FOLFOX and IMRT) and then as maintenance therapy for treating patients with localised unresectable oesophageal cancer. This is a randomized, French national, multicentre, comparative phase II trial

carcinoma
potassium
measurable disease
oxaliplatin
cancer
  • 3 views
  • 10 Aug, 2022
  • 4 locations
Oral Decitabine and Tetrahydrouridine as Epigenetic Priming for, Pembrolizumab-Mediated Immune Checkpoint Blockade in Patients With Inoperable, or Unresectable Locally Advanced or Metastatic Non-Small Cell Lung Cancers and Esophageal Carcinomas

Background Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Lung cancer is the leading cause of cancer-related death in the United States. Most people with lung cancer are already in the advanced stages of the disease by the time they see a doctor. Researchers want …

measurable disease
corticosteroids
absolute neutrophil count
cancer
lung carcinoma
  • 21 views
  • 11 Aug, 2022
  • 1 location
Clinical Study of CEA-targeted CAR-T Therapy for CEA-positive Advanced Malignant Solid Tumors

This trial is an open-label, single-arm clinical study. The main purpose is to verify the safety and efficacy of CAR-T cell preparations in the treatment of CEA-positive advanced malignant tumors, and to obtain the recommended dose and infusion scheme of CAR-T cell preparations for the treatment of patients with CEA-positive …

kidney function test
cyclophosphamide
cancer
esophagus cancer
gastric cancer
  • 0 views
  • 11 Aug, 2022
  • 1 location
A Study of SGN-PDL1V in Advanced Solid Tumors

This study will test the safety of a drug called SGN-PDL1V in participants with solid tumors. It will also study the side effects of this drug. A side effect is anything a drug does to your body besides treating your disease. Participants will have solid tumor cancer that has spread …

lung cancer
carcinoma
lung carcinoma
measurable disease
cancer
  • 0 views
  • 09 Aug, 2022
  • 3 locations
Real-life Study of Changes of Gastroesophageal Reflux Disease Manifestations Due to Behavioural and Diet Adherence

This study is aimed to investigate the role of long-term diet adherence on manifestations of gastroesophageal reflux disease

regurgitation
acidity
oesophageal ph
proton pump inhibitors
heartburn
  • 31 views
  • 08 Aug, 2022
  • 1 location
Maternal Role in Oral Feed Establishment in Preterm Neonates

Hypothesis Preterm babies who receive sensory motor stimulation from their mothers as compared to trained nurses will Start taking oral feed at the same time as compared to control group Take the same amount of milk at the commencement of oral feeding Take milk with equal efficiency Not face more …

Accepts healthy volunteers
  • 0 views
  • 11 Aug, 2022
  • 1 location
A Study of TAK-500 With or Without Pembrolizumab in Adults With Select Locally Advanced or Metastatic Solid Tumors

This study is about TAK-500, given either alone or with pembrolizumab, in adults with select locally advanced or metastatic solid tumors. The aims of the study are: to assess the safety profile of TAK-500 when given alone and when given with pembrolizumab. to assess the effects of TAK-500, when given …

carcinoma
pembrolizumab
alopecia
cancer
lung carcinoma
  • 11 views
  • 10 Aug, 2022
  • 1 location
Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers

This trial studies tucatinib to find out if it is safe when given with trastuzumab and other anti-cancer drugs (pembrolizumab, FOLFOX, and CAPOX). It will look at what side effects happen when participants take this combination of drugs. A side effect is anything the drug does other than treating cancer. …

measurable disease
cancer
folfox regimen
trastuzumab
capecitabine
  • 36 views
  • 10 Aug, 2022
  • 15 locations
Niraparib in the Treatment of Patients With Advanced PALB2 Mutated Tumors

The purpose of this study is to further evaluate the efficacy and safety of niraparib in patients with locally advanced or metastatic solid tumors and a pathogenic or likely pathogenic tumor PALB2 (tPALB2) mutation.

formalin-fixed paraffin-embedded
corticosteroid
solid tumor
palb2
  • 1 views
  • 09 Aug, 2022
  • 68 locations
A Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety of Vonoprazan in Adolescents With Symptomatic Gastroesophageal Reflux Disease

The primary objective of this study is to evaluate the pharmacokinetic profile of vonoprazan in adolescent participants with symptomatic gastroesophageal reflux disease (GERD).

  • 0 views
  • 11 Aug, 2022
  • 5 locations