Crohn's Disease (Pediatric) Clinical Trials

A listing of Crohn's Disease (Pediatric) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 121 clinical trials
A Study to Evaluate Efficacy, of Early Versus Late Use of Vedolizumab in Crohn's Disease: the LOVE-CD Study (LOVE-CD)

This multi-centre open label study will involve a minimum of 260 patients in 2 cohorts: 86 patients with 'early CD' defined as disease duration < 24 months and no other treatments than corticosteroids and/or thiopurines and 174 patients with 'late CD' defined as active disease despite treatment with immunosuppressives and …

thiopurines
corticosteroids
tumor necrosis factor
vedolizumab
endoscopy
  • 3 views
  • 26 Jan, 2022
  • 17 locations
Value of Pharmacokinetic Assays in the Prediction of Induction and Maintenance Therapeutic Response in Crohn's Disease (VEDO-PREDIRESP)

Vedolizumab (VDZ) is a monoclonal antibody which has shown its efficacy in Crohn's disease by inducing and maintaining clinical response/remission. The French marketing authorization was obtained for Crohn's disease in patients in failure with anti-TNF (Tumor Necrosis Factor) agents. For Crohn's disease patients treated with vedolizumab, a strong association between …

azathioprine
crohn's disease
mesalamine
remission
antibiotic therapy
  • 0 views
  • 26 Jan, 2022
  • 4 locations
An Open-Label, Proof of Consent Study of Vorinostat for the Treatment of Mdoerate-to-Severe Crohn s Disease and Maintenance Therapy With Ustekinumab

Background Crohn s disease (CD) is an inflammatory bowel disease. It causes inflammation of the gut. Symptoms may include diarrhea, abdominal pain, fatigue, weight loss and malnutrition. CD has no cure, but symptoms can sometimes be controlled with medicine. Researchers want to see if it is safe to treat CD …

azathioprine
crohn's disease
mesalamine
ciprofloxacin
inflammatory bowel disease
  • 53 views
  • 23 Jul, 2022
  • 1 location
Autologous Stem Cell Transplant for Crohn's Disease

Crohn's Disease (CD) is an inflammatory bowel disease. It can lead to significant complications and discomfort in the stomach and intestines. Crohn's disease is a debilitating, incurable disease of immune cells; it affects almost 1 million people in the United States. CD is characterized by inflammation of the stomach and …

azathioprine
crohn's disease
endoscopy
inflammatory bowel disease
enteropathy
  • 81 views
  • 09 Aug, 2022
  • 1 location
Surgical Prevention of Anastomotic Recurrence by Excluding Mesentery in Crohn's Disease

Kono and collegues have described a new anastomotic technique to restore bowel contintuity after ileocecal resection for Crohn's disease (CD). This tecnique implies a hand-sewn ileocolic anastomosis, that involves exclusively the antimesenteric side of the bowel and that functionally acts as an end-to-end anastomosis. In a retrospective study, the authors …

  • 55 views
  • 21 Jan, 2021
  • 2 locations
Low Dose IL-2 for the Treatment of Crohn's Disease

The purpose of this study is to determine the safety and maximum effective dose (MED) of Interleukin-2 in subjects with moderate-to-severe crohn's disease.

azathioprine
corticosteroids
crohn's disease
ileal disease
remission
  • 0 views
  • 06 Jun, 2022
  • 3 locations
A Phase 3, Open-label, Multicenter Study to Evaluate the Safety and Efficacy of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease

The purpose of this study is to evaluate the safety of Guselkumab in participants with Crohn's disease.

colitis
crohn's disease
endoscopy
ileocolitis
abdominal pain
  • 17 views
  • 15 Sep, 2022
  • 23 locations
A Phase 1/2a Double-Blind, Randomized, Placebo-Controlled Trial to Assess the Safety and Efficacy of Oral Administration of EcoActive on Intestinal Adherent Invasive Escherichia Coli (AIEC) in Patients With Inactive Crohn's Disease (CD)

This study will evaluate the safety of oral administration of EcoActive to patients with inactive Crohn's disease and how it affects the levels of AIEC in stool.

Accepts healthy volunteers
faecal calprotectin
crohn's disease
fecal calprotectin level
remission
  • 23 views
  • 22 Sep, 2022
  • 1 location
Modulating Early Life Microbiome Through Dietary Intervention in Crohn's Disease

The MELODY Trial: Modulating Early Life Microbiome through Dietary Intervention in Crohn's Disease, will test whether a non-invasive dietary intervention during pregnancy can improve the gut microbiota composition in both pregnant Crohn's disease patients and their babies during the sensitive time window of infant immune system development, and whether this …

Accepts healthy volunteers
microbiota
crohn's disease
  • 43 views
  • 10 Feb, 2022
  • 2 locations
Fecal Microbial Transplantation and Vedolizumab Treatment of Crohn's Disease

The investigators postulate that by determining a patient's baseline microbiome and manipulating it through fecal microbial transplantation (FMT) may improve response rates to vedolizumab in Crohn's disease (CD) patients. Primary objective: To determine whether manipulation of gut microbiome by FMT pre vedolizumab treatment is safe and results in higher remission …

crohn's disease
vedolizumab
remission
  • 10 views
  • 03 Mar, 2022
  • 2 locations