Joint Injuries Clinical Trials

A listing of Joint Injuries medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 98 clinical trials
A Study to Assess Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis at Risk for Pulmonary Hypertension

A randomized, double-blind, placebo-controlled dose escalation and verification study to assess the safety and efficacy of pulsed inhaled nitric oxide (iNO) in subjects at risk for pulmonary hypertension associated with pulmonary fibrosis on long term oxygen therapy (Part 1 and Part 2) - REBUILD

fibrosis
endothelin
nitric oxide
right heart catheterization
left ventricular end-diastolic pressure
  • 168 views
  • 13 Aug, 2021
  • 55 locations
Effect of Exercise Training in Patients With Pulmonary Hypertension

Pulmonary Hypertension (PH) is a serious disease with a dismal prognosis when left untreated. Advances in medical therapy have improved survival according to recent registries and systematic reviews, but are associated with high healthcare costs. Earlier studies in Heidelberg, Germany showed good evidence for the effect of exercise training on …

pulmonary arterial pressure
diuretics
  • 0 views
  • 26 Jan, 2021
  • 1 location
Study of Angiogenic Cell Therapy for Progressive Pulmonary Hypertension: Intervention With Repeat Dosing of eNOS-enhanced EPCs

The SAPPHIRE clinical trial seeks to establish the efficacy and safety of repeated monthly dosing of autologous EPCs transfected with human eNOS (heNOS) in patients with symptomatic severe PAH on available PAH-targeted medical therapy.

right heart catheterization
left ventricular end-diastolic pressure
oxygen saturation
scleroderma
assisted ventilation
  • 10 views
  • 20 Jul, 2021
  • 9 locations
A Study of Oral Nitrate in Adults With Pulmonary Hypertension With Heart Failure and Preserved Ejection Fraction

This is an open-label, single-center study to examine distinguishing features of the structure and function of the oral and gut microbiome in healthy adult normal volunteers compared to volunteers with PH-HFpEF in the breakdown of oral nitrate.

ejection fraction
right heart catheterization
heart failure
hypertension
heart disease
  • 21 views
  • 15 Sep, 2021
  • 2 locations
Outpatient Vasodilator Assessment Using Iloprost in Pulmonary Hypertension

This study will compare the clinical efficacy of inhaled iloprost as an invasive, selective vasodilator in the cardiac catheterization laboratory in patients with pulmonary hypertension to the gold standard of inhaled nitric oxide. It will also examine whether echocardiographic estimates of response to inhaled iloprost can predict responsiveness to invasive …

iloprost
nitric oxide
vasodilator
  • 1 views
  • 11 Jul, 2021
  • 1 location
Peripheral Systemic Thrombolysis Versus Catheter Directed Thrombolysis for Submassive PE

To determine whether peripheral low dose systemic thrombolysis (PLST) is non-inferior to catheter directed acoustic pulse thrombolysis (ACDT) in improving RV function and reducing pulmonary artery pressures in submassive pulmonary embolism (PE)

troponin t
troponin
ct scan
pulmonary embolism
alteplase
  • 71 views
  • 14 Mar, 2021
  • 2 locations
Effect of Exercise and Respiratory Therapy on Right Ventricular Function in Severe Pulmonary Hypertension

Chronic pulmonary hypertension (PH) is associated with impaired exercise capacity, quality of life and right ventricular function.The disease is characterized by an increase of pulmonary vascular resistance and pulmonary arterial pressure, leading to right heart insufficiency. In later stages of the disease, the right heart is not able to further …

right heart catheterization
pulmonary arterial hypertension
heart failure
pulmonary arterial pressure
  • 7 views
  • 11 May, 2021
  • 1 location
Effect of Home Rehabilitation on State of Patients With PAH HFREF and IHD

The aim of the study is to evaluate the influence of physical training and respiratory rehabilitation performed by patients at home on quality of life, symptoms, physical endurance, force of respiratory and skeletal muscles and body mass composition in patients with pulmonary arterial hypertension (PAH) or left ventricular heart failure …

ejection fraction
heart failure
rehabilitation therapy
hypertension
connective tissue diseases
  • 8 views
  • 21 Feb, 2021
  • 2 locations
Acute Decompensation of Pulmonary Hypertension

The main objective of this study is to analyze the survival of a cohort of patients admitted for acute decompensation of pulmonary arterial hypertension or postembolic pulmonary hypertension and to establish the prognostic value of biomarkers.

diuretic therapy
chronic thromboembolic pulmonary hypertension
pulmonary arterial hypertension
diuretics
  • 0 views
  • 24 Jan, 2021
  • 1 location
Training Single Arm

The pulmonary hypertension is a disease, which tends to a progredient right heart failure. Although there was a large progress in development of medical therapy, the quality of life, the physical efficiency and the prognosis of the patients are still limited. The aim of the study is to examine the …

right heart catheterization
heart failure
right ventricular failure
  • 1 views
  • 10 May, 2021
  • 1 location