Joint Injuries Clinical Trials

A listing of Joint Injuries medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 98 clinical trials
A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD)

The primary objective of this study is to demonstrate the efficacy of inhaled treprostinil compared to placebo in improving exercise ability as measured by change from baseline in 6-Minute Walk Distance (6MWD) following 12 weeks of active treatment in participants with PH-COPD.

left ventricular end-diastolic pressure
diuretics
forced expiratory volume
treprostinil
vasodilator
  • 2043 views
  • 26 Aug, 2021
  • 67 locations
A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension

The purpose of this study is to evaluate whether the addition of selexipag to standard of care treatment delays disease progression in children with Pulmonary Arterial Hypertension (PAH) in comparison to placebo.

endothelin
heart disease
endothelin receptor antagonist
right heart catheterization
primary pulmonary hypertension
  • 201 views
  • 10 Sep, 2021
  • 154 locations
A Study of Ralinepag to Evaluate Effects on Exercise Capacity by CPET in Subjects With WHO Group 1 PH

Study ROR-PH-302, ADVANCE CAPACITY, is designed to evaluate the effects of ralinepag therapy on exercise capacity as assessed by change in peak oxygen consumption (VO2) derived from cardiopulmonary exercise testing (CPET) after 28 weeks of treatment

diuretics
ralinepag
stress test
exercise stress test
endothelin receptor antagonist
  • 0 views
  • 22 Sep, 2021
  • 32 locations
A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients

Study ROR-PH-301, ADVANCE OUTCOMES, is designed to assess the efficacy and safety of ralinepag when added to pulmonary arterial hypertension (PAH) standard of care or PAH-specific background therapy in subjects with World Health Organization (WHO) Group 1 PAH.

diuretics
angiotensin
ralinepag
hypertension
beta-blocker
  • 5463 views
  • 24 Sep, 2021
  • 308 locations
Clinical Study of Intra Articular Injection of Catholic MASTER Cell (Bone Marrow Derived Mesenchymal Stem Cell) in Knee Osteoarthritis

>Osteoarthritis is severe and intractable musculoskeletal disease that eventually leads to joint failure and pain due to inflammation and joint injury. OA is one of the most prevalent diseases. The

total knee replacement
intra-articular injection
NSAID
osteoarthritis
x-rays
  • 8 views
  • 23 Jan, 2021
  • 1 location
Effects of Inspiratory Muscle Training in Patients With Pulmonary Hypertension

This study aims to determine the possible effects of inspiratory muscle training on cardiovascular, respiratory, physical and psychosocial functions in patients with PH.

  • 0 views
  • 25 Jan, 2021
  • 1 location
MK-5475 in Participants With Pulmonary Hypertension Associated With Chronic Obstructive Pulmonary Disease (PH-COPD) (MK-5475-006)

The main purpose of this study is to assess MK-5475 in the PH-COPD population by evaluating the safety, pharmacokinetics (PK), changes in pulmonary vascular resistance (PVR), and changes in pulmonary blood volume (PBV) after administration. The primary study hypothesis is that the MK-5475 results in superior reduction of the mean …

dyspnea
right heart catheterization
pulmonary disease
  • 19 views
  • 24 Sep, 2021
  • 6 locations
Selexipag for the Treatment of Schistosomiasis-Associated Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a severe, progressive and potentially fatal disease that impairs the pulmonary circulation and leads to right ventricular failure. One of the world most prevalent etiologies of PAH is schistosomiasis-associated pulmonary arterial hypertension (Sch-PAH). New drugs have emerged to treat other forms of PAH, but their …

right ventricular failure
phosphodiesterase-5 (pde-5) inhibitor
endothelin receptor antagonist
endothelin
pulmonary arterial hypertension
  • 0 views
  • 26 Jan, 2021
  • 1 location
THERAPY-HYBRID-BPA Trial

Riociguat could improve the exercise capacity and residual symptoms in patients with chronic thromboembolic pulmonary hypertension (CTEPH) even after normalization of pulmonary arterial pressure by balloon pulmonary angioplasty (BPA). This randomized controlled trial study aimed to clarify whether the improvement of peak cardiac index (CI) during exercise maintains or not …

riociguat
right heart catheterization
  • 2 views
  • 26 Jan, 2021
  • 1 location
Levosimendan Administration in Pulmonary Hypertension

The aim of the study is to examine the pharmacokinetics and pharmacodynamic properties of Levosimendan in cardiac surgery patients with pulmonary hypertension and impaired right ventricular function.

hypertension
anesthesia
levosimendan
left ventricular dysfunction
  • 0 views
  • 30 Jan, 2021
  • 1 location