Heart Valve Disease Clinical Trials

A listing of Heart Valve Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 151 clinical trials
Balloon vs. Self Expanding Transcatheter Valve for Degenerated Bioprosthesis (BASELINE)

Transcatheter aortic valve implantation (TAVI) serves a growing spectrum of patients with symptomatic severe aortic stenosis (AS). Approximately 80% of surgical aortic valve replacements is performed using a bioprosthesis1. Durability of surgical bioprostheses varies based on the patient's age at the moment of implantation, type and size etc2. TAVI has …

tavi
transcatheter aortic valve implantation
regurgitation
stenosis
aortic valve replacement
  • 1 views
  • 11 Aug, 2022
  • 1 location
TRILUMINATE Pivotal Trial

The primary objective of this trial is to demonstrate the safety and effectiveness of the TriClip device in improving clinical outcomes in symptomatic patients with severe tricuspid regurgitation (TR), who are at intermediate or greater estimated risk for mortality or morbidity with tricuspid valve surgery. This randomized controlled trial will …

medical therapy
diuretics
regurgitation
heart failure
fibrillation
  • 156 views
  • 10 Aug, 2022
  • 79 locations
Von Willebrand Factor Point-of-care Testing to Improve Minimally Invasive TAVI Outcomes (WITAVI-REAL)

Paravalvular regurgitation (PVR) is an important complication of Transcatheter Aortic Valve Implantation (TAVI) that is associated with a 2.5-fold increase risk of mortality. Transesophageal echocardiographic (TEE) is considered as the gold standard to assess the severity of PVR and guide the physician to perform corrective procedures during TAVI, but it …

tavi
transcatheter aortic valve implantation
regurgitation
stenosis
aortic valve stenosis
  • 2 views
  • 27 May, 2022
  • 1 location
The ENCIRCLE Trial (ENCIRCLE)

This study will establish the safety and effectiveness of the SAPIEN M3 System in subjects with symptomatic, at least 3+ mitral regurgitation (MR) for whom commercially available surgical or transcatheter treatment options are deemed unsuitable.

regurgitation
heart failure
  • 24 views
  • 17 Jun, 2022
  • 52 locations
Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial (CLASP II TR)

To establish the safety and effectiveness of the Edwards PASCAL Transcatheter Repair System in patients with symptomatic severe tricuspid regurgitation who have been determined to be at an intermediate or greater estimated risk of mortality with tricuspid valve surgery by the cardiac surgeon with concurrence by the local Heart Team

medical therapy
regurgitation
heart failure
tricuspid valve repair
  • 18 views
  • 17 Jun, 2022
  • 48 locations
Feasibility Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk

to evaluate the feasibility, safety and performance of the HighLife 28mm Transcatheter Mitral Valve in patients with moderate-severe or severe mitral regurgitation who are at high risk for surgical treatment.

mitral valve replacement
medical therapy
heart surgery
regurgitation
  • 72 views
  • 09 Jul, 2022
  • 39 locations
Treatment of Mitral Regurgitation Using a Minimally Invasive Approach With the HARPOON Device. (ASCEND)

To evaluate the long-term safety and performance of the HARPOON™ MVRS for use in patients presenting with severe degenerative mitral regurgitation due to posterior leaflet prolapse in the post-market phase.

mitral valve disease
mitral valve repair
heart mitral valve
prolapse
regurgitation
  • 0 views
  • 11 Aug, 2022
  • 15 locations
Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. (APOLLO)

Multi-center, global, prospective, non-randomized, interventional, pre-market trial. All subjects enrolled with receive the study device.

mitral valve replacement
regurgitation
  • 653 views
  • 12 Aug, 2022
  • 55 locations
Portico Re-sheathable Transcatheter Aortic Valve System US IDE Trial (PORTICO-IDE)

The objective of the PORTICO pivotal IDE trial is to evaluate the safety and effectiveness of the St Jude Medical (SJM) Portico Transcatheter Heart Valve and Delivery Systems (Portico) in the treatment of severe symptomatic aortic stenosis via transfemoral and alternative delivery methods in high risk and extreme risk patients.

symptomatic aortic stenosis
aortic valve stenosis
stenosis
  • 187 views
  • 30 Apr, 2022
  • 19 locations
ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement

To evaluate safety and effectiveness of the ACURATE Transfemoral Aortic Valve System for transcatheter aortic valve replacement (TAVR) in subjects with severe native aortic stenosis who are indicated for TAVR.

dobutamine
transcatheter aortic valve implantation
aortic valve stenosis
regurgitation
aortic valve replacement
  • 84 views
  • 01 Jul, 2022
  • 83 locations