Heart Valve Disease Clinical Trials

A listing of Heart Valve Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 25 clinical trials
Transcatheter Mitral Valve Replacement With the Medtronic Intrepid TMVR System in Patients With Severe Symptomatic Mitral Regurgitation

Multi-center, global, prospective, non-randomized, interventional, pre-market trial. All subjects enrolled with receive the study device.

mitral valve replacement
regurgitation
  • 481 views
  • 22 Jul, 2021
  • 58 locations
Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

To establish the safety and effectiveness of the Edwards PASCAL Transcatheter Repair System in patients with symptomatic severe tricuspid regurgitation who have been determined to be at an intermediate or greater estimated risk of mortality with tricuspid valve surgery by the cardiac surgeon with concurrence by the local Heart Team

tricuspid valve repair
heart failure
regurgitation
medical therapy
  • 10 views
  • 24 Jul, 2021
  • 34 locations
Treatment of Mitral Regurgitation Using a Minimally Invasive Approach With the HARPOON Device.

To evaluate the long-term safety and performance of the HARPOON MVRS for use in patients presenting with severe degenerative mitral regurgitation due to posterior leaflet prolapse in the post-market phase.

mitral valve disease
regurgitation
mitral valve repair
prolapse
heart mitral valve
  • 0 views
  • 23 Jul, 2021
  • 16 locations
ACURATE IDE: Safety and Efficacy Study of Acurate Valve for Transcatheter Aortic Valve Replacement

To evaluate safety and effectiveness of the ACURATE Transfemoral Aortic Valve System for transcatheter aortic valve replacement (TAVR) in subjects with severe native aortic stenosis who are indicated for TAVR.

dobutamine
aortic valve replacement
transcatheter aortic valve implantation
stenosis
cancer
  • 76 views
  • 17 Jul, 2021
  • 87 locations
PROACT Xa - A Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely on Apixaban

Currently, warfarin is the only approved anticoagulation for patients with mechanical valves. The purpose of this study is to determine if participants with an On-X Prosthetic Heart Valve / On-X aortic valve can be maintained safely and effectively on apixaban. Both the On-X aortic valve and apixaban have been approved …

aspirin
apixaban 5 mg
warfarin
  • 79 views
  • 28 Jul, 2021
  • 75 locations
TRISCEND II Pivotal Trial

Pivotal trial to evaluate the safety and effectiveness of the Edwards EVOQUE tricuspid valve replacement system

medical therapy
regurgitation
  • 0 views
  • 19 Jul, 2021
  • 26 locations
The Impact of a Smartphone-based Personalized Intervention on Cognitive and Cerebrovascular Health in CIRCLE-CHINA

This smartphone-based personalized multiple intervention study aims to prevent cognitive impairment and reduce dementia and cerebrovascular events in 45-74 year old persons with high risk of stroke in China. The investigators plan to monitor and manage participants' behavioral and health (vascular risk factors control, sleep quality, mental health and cognitive …

dementia
diabetes
cognitive impairment
mental deterioration
transient ischemic attack
  • 0 views
  • 31 Jul, 2021
  • 1 location
Beating Heart Mitral Valve Repair With the HARPOON System

The objective of the study is to evaluate the safety and effectiveness of the HARPOON System in the treatment of patients with severe degenerative mitral regurgitation (DMR).

prolapse
regurgitation
mitral valve repair
  • 0 views
  • 26 Jul, 2021
  • 17 locations
Treatment of Aortic Stenosis in Brazil: Cost-Utility Analysis of TAVI vs SAVR

TEAM-Br is a randomized, prospective, cost-utility study comparing transcatheter aortic valve implantation (TAVI) versus surgical aortic vale replacement in Brazil. The study is sponsored by the national Minister of Health, through PROADI-SUS (Programa de Apoio ao Desenvolvimento Institucional do SUS).

tavi
aortic valve replacement
stenosis
  • 0 views
  • 25 Jul, 2021
  • 1 location
PrizValve Transcatheter Aortic Valve Replacement Study

The purpose of this clinical study is to evaluate the effectiveness and safety of the transcatheter aortic valve system in the treatment of patients with severe aortic stenosis who are at high risk of surgery or who are not suitable for surgery.

transcatheter aortic valve implantation
aortic valve replacement
stenosis
aortic valve stenosis
  • 0 views
  • 18 Jul, 2021
  • 1 location