Heart Valve Disease Clinical Trials

A listing of Heart Valve Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 404 clinical trials
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Heart Valve Disease – Aortic and Mitral

Study Description: Multi-center, international, prospective, randomized, interventional, pre-market study. Patients will be seen at pre and post-procedure, discharge, 30 days, 6 months, 1 year, 18 months, and annually through 10 years. Randomly assigned (50% to either group) Treatment of Aortic Stenosis with either Transcatheter Aortic Valve Replacement (TAVR) device or …

aortic valve replacement
stenosis
  • 776 views
  • 05 Feb, 2021
  • 1 location
featured
TRISCEND II

Patients suffering from heart failure not responsive to optimal medical therapy and who are diagnosed with tricuspid valve insufficiency should be considered for this pivotal clinical trial.

  • 0 views
  • 27 Apr, 2021
  • 1 location
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BRIDGE: Bridging Anticoagulation in Patients who Require Temporary Interruption of Warfarin Therapy for an Elective Invasive Procedure or Surgery

BRIDGE: Bridging Anticoagulation in Patients who Require Temporary Interruption of Warfarin Therapy for an Elective Invasive Procedure or Surgery

  • 30 views
  • 25 Mar, 2021
  • 1 location
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Low Risk TAVR-The purpose of this research study is to determine if replacing the aortic valve without open-heart surgery is as safe as or safer than open-heart surgery in patients who are considered at low risk for complications from surgery.

Low Risk TAVR-The purpose of this research study is to determine if replacing the aortic valve without open-heart surgery is as safe as or safer than open-heart surgery in patients who are considered at low risk for complications from surgery.

  • 534 views
  • 25 Mar, 2021
  • 1 location
Study of the Effect of the Benfluorex

More than 5 million persons in France exposed, in last years, to the taking of the Benfluorex. Arisen, at certain patients, of a valvulopathy characterized by mitrals and/or aortic leaks

  • 0 views
  • 26 Jan, 2021
  • 12 locations
Gene Therapy in Patients With Mucopolysaccharidosis Disease

This study investigated the safety and efficacy of gene therapy approaches for Mucopolysaccharidosis type VI disease caused by the deficiency of arylsulfatase B (ARSB) enzyme. The aim of the study is to evaluate the safety and efficacy of the treatment.

  • 1 views
  • 25 Jan, 2021
  • 3 locations
TRILUMINATE Pivotal Trial

The primary objective of this trial is to demonstrate the safety and effectiveness of the TriClip device in improving clinical outcomes in symptomatic patients with severe tricuspid regurgitation (TR), who are at intermediate or greater estimated risk for mortality or morbidity with tricuspid valve surgery. This randomized controlled trial will …

fibrillation
heart failure
tricuspid valve repair
diuretics
mitral regurgitation
  • 117 views
  • 02 Aug, 2021
  • 87 locations
Von Willebrand Factor Point-of-care Testing to Improve Minimally Invasive TAVI Outcomes

Paravalvular regurgitation (PVR) is an important complication of Transcatheter Aortic Valve Implantation (TAVI) that is associated with a 2.5-fold increase risk of mortality. Transesophageal echocardiographic (TEE) is considered as the gold standard to assess the severity of PVR and guide the physician to perform corrective procedures during TAVI, but it …

symptomatic aortic stenosis
regurgitation
point-of-care testing
stenosis
aortic valve stenosis
  • 0 views
  • 26 Jan, 2021
  • 1 location
Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair

The objective of this trial is to assess the safety and effectiveness of the study device in subjects with degenerative mitral valve disease receiving a mitral valve repair without cardiopulmonary bypass (treatment group) when compared to subjects receiving mitral valve repair using standard surgical techniques with cardiopulmonary bypass (control group).

mitral valve repair
mitral valve disease
cardiopulmonary bypass
annuloplasty
prolapse
  • 0 views
  • 23 Jan, 2021
  • 17 locations
Feasibility Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk

to evaluate the feasibility, safety and performance of the HighLife 28mm Transcatheter Mitral Valve in patients with moderate-severe or severe mitral regurgitation who are at high risk for surgical treatment.

regurgitation
mitral valve replacement
heart surgery
medical therapy
  • 68 views
  • 04 Jun, 2021
  • 32 locations