Heart Valve Disease Clinical Trials

A listing of Heart Valve Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 382 clinical trials
Featured trial
Heart Valve Disease – Aortic and Mitral

Study Description: Multi-center, international, prospective, randomized, interventional, pre-market study. Patients will be seen at pre and post-procedure, discharge, 30 days, 6 months, 1 year, 18 months, and annually through 10 years. Randomly assigned (50% to either group) Treatment of Aortic Stenosis with either Transcatheter Aortic Valve Replacement (TAVR) device or …

aortic valve replacement
stenosis
  • 799 views
  • 05 Feb, 2021
  • 1 location
Featured trial
BRIDGE: Bridging Anticoagulation in Patients who Require Temporary Interruption of Warfarin Therapy for an Elective Invasive Procedure or Surgery

BRIDGE: Bridging Anticoagulation in Patients who Require Temporary Interruption of Warfarin Therapy for an Elective Invasive Procedure or Surgery

  • 92 views
  • 25 Mar, 2021
  • 1 location
Featured trial
Low Risk TAVR-The purpose of this research study is to determine if replacing the aortic valve without open-heart surgery is as safe as or safer than open-heart surgery in patients who are considered at low risk for complications from surgery.

Low Risk TAVR-The purpose of this research study is to determine if replacing the aortic valve without open-heart surgery is as safe as or safer than open-heart surgery in patients who are considered at low risk for complications from surgery.

  • 534 views
  • 25 Mar, 2021
  • 1 location
Balloon vs. Self Expanding Transcatheter Valve for Degenerated Bioprosthesis (BASELINE)

Transcatheter aortic valve implantation (TAVI) serves a growing spectrum of patients with symptomatic severe aortic stenosis (AS). Approximately 80% of surgical aortic valve replacements is performed using a bioprosthesis1. Durability of surgical bioprostheses varies based on the patient's age at the moment of implantation, type and size etc2. TAVI has …

aortic valve replacement
stenosis
tavi
transcatheter aortic valve implantation
regurgitation
  • 1 views
  • 11 Aug, 2022
  • 1 location
Study of Transcatheter Tricuspid Annular Repair (STTAR)

The purpose of the study is to evaluate the safety and performance of the MIA Minimally Invasive Annuloplasty Device in patients with chronic functional tricuspid regurgitation.

functional tricuspid regurgitation
cardiopulmonary bypass
annuloplasty
ejection fraction
regurgitation
  • 49 views
  • 15 Feb, 2022
  • 6 locations
TRILUMINATE Pivotal Trial

The primary objective of this trial is to demonstrate the safety and effectiveness of the TriClip device in improving clinical outcomes in symptomatic patients with severe tricuspid regurgitation (TR), who are at intermediate or greater estimated risk for mortality or morbidity with tricuspid valve surgery. This randomized controlled trial will …

tricuspid valve repair
diuretics
fibrillation
mitral regurgitation
repair of tricuspid valve
  • 156 views
  • 10 Aug, 2022
  • 79 locations
Von Willebrand Factor Point-of-care Testing to Improve Minimally Invasive TAVI Outcomes (WITAVI-REAL)

Paravalvular regurgitation (PVR) is an important complication of Transcatheter Aortic Valve Implantation (TAVI) that is associated with a 2.5-fold increase risk of mortality. Transesophageal echocardiographic (TEE) is considered as the gold standard to assess the severity of PVR and guide the physician to perform corrective procedures during TAVI, but it …

stenosis
tavi
aortic valve stenosis
symptomatic aortic stenosis
transcatheter aortic valve implantation
  • 2 views
  • 27 May, 2022
  • 1 location
A Clinical Evaluation of the Safety and Effectiveness of the MitraClip System in the Treatment of Clinically Significant Functional Mitral Regurgitation

To study the safety and effectiveness of the MitraClip System in the treatment of clinically significant functional mitral regurgitation in patients with New York Heart Association (NYHA) Functional Class II to Class IV chronic heart failure.

diuretics
ejection fraction
blood pool scan
functional mitral regurgitation
MRI
  • 205 views
  • 30 Jun, 2021
  • 28 locations
Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair (ReChord)

The objective of this trial is to assess the safety and effectiveness of the study device in subjects with degenerative mitral valve disease receiving a mitral valve repair without cardiopulmonary bypass (treatment group) when compared to subjects receiving mitral valve repair using standard surgical techniques with cardiopulmonary bypass (control group).

mitral valve disease
prolapse
mitral valve repair
cardiopulmonary bypass
annuloplasty
  • 0 views
  • 26 Jan, 2022
  • 15 locations
The ENCIRCLE Trial (ENCIRCLE)

This study will establish the safety and effectiveness of the SAPIEN M3 System in subjects with symptomatic, at least 3+ mitral regurgitation (MR) for whom commercially available surgical or transcatheter treatment options are deemed unsuitable.

heart failure
regurgitation
  • 24 views
  • 17 Jun, 2022
  • 52 locations