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Diabetes Mellitus, Type 2 Clinical Trials

A listing of Diabetes Mellitus, Type 2 medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (135) clinical trials

Insulin Resistance and Mild Cognitive Impairment (IRMCI) Study

General Introduction In this trial, the drug to be studied is Metformin. It is an insulin-sensitizing biguanide which has long been used safely as an effective antidiabetic drug for patients with type II diabetes. Rationale for the Study Purpose Dementia is a clinical syndrome due to multiple aetiologies, of which ...


An Investigation Into The Anti-hypertensive And Potential Anti-inflammatory Actions Of Dapagliflozin

Two groups of 26 patients each (total 52 patients) with type 2 diabetes on oral agents will be included in the study. One group will be randomized to dapagliflozin (a dose of 5 mg daily will be titrated to 10 mg daily during the first week) while the other will ...


Effect of GLP-1 on Angiogenesis

GLP-1 receptor agonists are introduced in the treatment of type 2 Diabetes (T2D) and their efficacy is documented. Beside their therapeutic benefits, direct cardiovascular effects have also been reported. However, safety aspects are also important to evaluate with respect to micro and macrovascular complications associated with T2D. T2D patients treated ...


Canagliflozin (Invokana ) vs. Standard Dual Therapy Regimen for T2DM During Ramadan

There are over one billion Muslims in the world with the majority participating in Ramadan. The prevalence of diabetes in several countries with large Muslim populations is similar to the rates observed in westernised countries, which increases by 10% annually as a result of urbanization and socioeconomic development. Observance of ...


Benefits of Insulin Supplementation for Correction of Hyperglycemia in Patients With Type 2 Diabetes

The management of patients with Type 2 diabetes involves treatment with two different types of insulin injections to control blood sugar levels. The doses of the two types of insulins, glargine insulin and aspart insulin are adjusted daily through the hospital stay based on blood sugar levels. Many times, in ...


ORal anticoaGulants in diAbetic and Nondiabetic Patients With nOn-valvular Atrial fibrillatioN (ORGANON)

Parameters evaluated: anthropometric indices glycated haemoglobin, basal and postprandial glycemia lipid profile small and dense LDL; oxidized LDL I troponin red and white cells count; platelets count creatinin, transaminases, iron fibrinogen, D-dimer, anti-thrombin III Hs-CRP, metalloproteinases 2 and 9 incidence of bleeding


The Statins on Glucose Homeostasis in Subjects With Impaired Fasting Glucose

Statin therapy effectively reduces cardiovascular events. However, trial data1 and meta-analyses suggest that statins also confer increased risk of development of diabetes. In order to elucidate whether statins increase risk of diabetes, investigators conducted this study to evaluate the effects of rosuvastatin (maybe the highest diabetogenic) and pravastatin (seems to ...


Effect of Acarbose and Vildagliptin on Visceral Fat Distribution in Newly Diagnosed Type 2 Diabetes Patients

Focusing on newly diagnosed type 2 diabetes participants with overweight and obesity (24kg/m2 body mass index 30kg/m2). 50 participants per arm (acarbose & lifestyle combination / vildagliptin & lifestyle combination), using abdominal computed tomography scans and other methods to evaluate the effects of acarbose and vildagliptin on visceral fat distribution ...


The Practical Evidence of Antidiabetic Combination Therapy in Korea

Pathophysiology of type 2 diabetes is known as insulin resistance and progressive beta cell dysfunction. Combination therapy with biguanides, glucagon-like peptide-1(GLP-1) agonists or dipeptidyl peptidase-4 inhibitor(DPP4I) and thiazolidinediones(TZD) seems reasonable theoretically, for their effects on different pathophysiologic defects. Current treatment guidelines recommend a stepwise approach starting with lifestyle modification or ...


Clinical Evaluation of Fenfuro (Fenugreek Seed Extract) in Type-2 Diabetic Subjects: an add-on Study

Diabetes mellitus, involving rise in blood sugar levels, has shown to be a highly prevalent disease. Treatments and treatment regimens include combinations of oral anti-diabetic drugs (OADs), anti-hypertensive medications and anti-dyslipidemic agents, but these have been less than successful in managing their respective disease targets with clinical goals. Now-a-days, the ...