Depression (Adult and Geriatric) Clinical Trials
A listing of Depression (Adult and Geriatric) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Found 173 clinical trials
Lay-Delivered Behavioral Activation in Senior Centers
In response to large numbers of senior center clients who suffer untreated depression and the dearth of geriatric mental health providers, the investigators have simplified Behavioral Activation to be delivered by lay volunteers ("Do More, Feel Better"; DMFB). The focus of Behavioral Activation is to guide clients to reengage in …
- 2 views
- 04 Oct, 2022
- 8 locations
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)
Purpose: To determine whether COX-1 and COX-2 are detectable in the brains of individuals with MDD experiencing a major depressive episode (MDE). Endpoints Primary Endpoint: Group A - Calculation of COX-2 density from [11C]MC1 PET scans, using baseline scans and scans after blockade with celecoxib. Group B - Calculation of …
- 3 views
- 10 Oct, 2022
- 1 location
Role of Slow-wave Activity and Plasticity in MDD
The hypothesis underlying this proposal is that deficits of synaptic plasticity underlie the slow-wave activity (SWA) abnormalities observed n major depressive disorder (MDD), and that manipulating SWA may serve to circumvent these deficits by facilitating an increase in synaptic strength via the inhibition of synaptic down-scaling, thereby improving plasticity and …
- 57 views
- 04 Oct, 2022
- 1 location
Transcranial Direct Current Stimulation (tDCS) Cost-utility-analysis in Medical Care on Depressive Episode With One Drug Therapy Failure. (DISCO)
The purpose of this study is to determine the transcranial direct current stimulation (tDCS) cost-utility in the depression therapy. This is a 3 years medico-economics study with 1 year follow-up period involving patients with 1 or 2 depression treatment(s) failed. Eligible subject will be randomized in 2 groups, usual care …
- 24 views
- 04 Oct, 2022
- 11 locations
An Open-Label Expanded Access Protocol for Esketamine Treatment of Subjects With Treatment Resistant Depression (TRD) Who do Not Have Other Treatment Alternatives
The purpose of this expanded access program (EAP) is to provide expanded access to esketamine treatment and collect additional safety data and quality of life until esketamine is commercially available for participants with Treatment-Resistant Depression (TRD).
- 186 views
- 28 Oct, 2022
- 7 locations
Testing Different Modes of Cognitive Behavior Therapy (CBT)
The purpose of this study is to test a novel behavioral treatment - Adapted Cognitive-Behavior Therapy (ACBT) - against standard Cognitive Behavior Therapy (CBT). The goal of the study is to determine if ACBT confers improved outcomes for women with depression and low literacy. Depression is a serious women's health …
- 127 views
- 15 Jul, 2022
- 1 location
DTA (Dopaminergic Therapy for Anhedonia) Study
The purpose of this 6-week, double-blind, placebo-controlled, crossover study is to explore new treatment options for people with depression who have high inflammation and anhedonia. Thirty-five male and female participants with depression, between the ages of 25-55 years of age, will be randomized to two study tracks (A and B) …
- 0 views
- 15 Mar, 2022
- 1 location
PREGBRAIN - Magnetic Stimulation of the Brain in Depressed Pregnant Women
Background Depression during pregnancy is common, afflicting 10-20% of pregnant women. Nevertheless, many women want to avoid antidepressant treatment during pregnancy, due to the possible impact on the unborn child. rTMS (repetitive transcranial magnetic stimulation) is a method where an electromagnetic coil is placed close to the head. Magnetic pulses …
- 0 views
- 06 Oct, 2021
- 1 location
Internet Based Psychological Support
The investigators have developed interactive, multimedia-intensive, computer-based treatment programs that include depression (Problem-Solving Therapy), stress management, and conflict management. Together the three modules are called PATH. The problem-solving module is based on an evidence-based psychotherapy called Problem-Solving Therapy in which depressed patients identify problems in their lives and work through …
- 16 views
- 02 May, 2022
- 1 location
Cognitive Behavior Therapy for Depression (CBT)
Psychological mindedness(PM) is a metacognitive process in which the person uses his cognitive and affective abilities to understand his thoughts, feelings, and his behaviors as they interact with his internal experiences and his external experiences in the world. It dynamically modifies his behavior to move towards self-actualization in a manner …
- 20 views
- 07 Oct, 2022
- 1 location