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Periodontitis Clinical Trials

A listing of Periodontitis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (80) clinical trials

Immediate Implant Placement in Aggressive Periodontitis

Aggressive periodontitis is an enigmatic periodontal disease that characterized by massive and undeterminable periods of tissue destruction. It gets along well to young individuals with successive periods of disease activity. Aggressive bone destruction with limited plaque and calculus deposits usually detected. According to microbial theory, Aggregatibacter actinomycetemcomitans (A.a) and P. ...

Phase N/A

Regenerative Endodontic Procedure of Immature Permanent Teeth With Apical Periodontitis Using PRF

The conventional method of regenerative endodontic procedure using a blood clot as scaffold materials has shown successful results. However, it is very difficult to induce bleeding and place mineral trioxide aggregate over a blood clot. Platelet-rich fibrin (PRF), a second-generation platelet concentrate. PRF is a matrix of autologous fibrin containing ...

Phase N/A

Investigation of Dental Health in Children With Neutrophil Defects: A Clinical Study

BACKGROUND Primary immunodeficiency diseases (PIDs) are a group of rare inherited disorders that are estimated to affect approximately 1 in 2,000 children. In PIDs there is an intrinsic defect in the human immune system, such as a failure to produce enough antibodies to fight infection, or a failure in the ...

Phase N/A

Influence of Mouth Breathing on Periodontal Healing

INTRODUCTION Mouth breathing is perceived to be responsible for persistant marginal gingivitis. The most common region to be affected by gingivitis in mouth breathers is maxillary anterior region. Other areas are affected in following decreasing order: maxillary posterior areas, mandibular anterior region and mandibular posterior region. Various reasons are considered ...

Phase N/A

Tobacco Cessation Intervention Study for Oral Diseases

It has been concluded that available evidence suggests that behavioral interventions for tobacco cessation conducted by oral health professionals incorporating an oral examination component in the dental office or community setting may increase tobacco abstinence rates among both cigarette smokers and smokeless tobacco users (Cochrane Database Syst Rev.6:CD005084.) However, efficacy ...

Phase N/A

Use of Scaffolds for Treatment of Gingival Recession Associated With Interproximal Tissue Deficiency

The treatment of gingival recessions associated with interproximal bone and gingival tissue deficiency, and also the absence of interdental papilla, are major challenges within the periodontics due to lacking predictability. However, an intervention in these cases is extremely important, since the presence of these defects is associated with aesthetic, phonetic, ...

Phase N/A

Amoxicillin and Metronidazole During Periodontal Treatment

The combination of systemic metronidazole (MTZ) and amoxicillin (AMX) to scaling and root planing (SRP) has shown to be a promising periodontal treatment. However, some essential issues associated with the use of these antibiotics remain to be established. Although these agents are often prescribed after the healing phase of the ...

Phase N/A

Treatment of Periodontitis in Obese Individuals

Obesity and gum diseases are highly prevalent in all parts of the world. Obesity can negatively influence severity and progression rates of gum diseases. Presence of fat in the body determines a general systemic state of inflammation. On the other hand, when gum diseases are successfully treated systemic and local ...


Calcium-vitamin D & Periodontal Therapy for Improving Metabolic and Inflammatory Profile Among Pregnant Women

The improvement of maternal and child health remains a key issue in global health. Production and improved accessibility of healthy and nutrient-rich milk-based products could potentially tackle health and nutrition inequalities in low-income countries. This study will assess the acceptability of a multi-component intervention, including provision of calcium/vitamin-D fortified milk ...

Phase N/A


The investigators wish to assess whether intensive periodontal therapy will reduce the burden of chronic periodontal disease and will cause regression or prevent progression of atherosclerosis assessed by a surrogate endpoint (carotid intimamedia thickness) at 24 months compared to control periodontal therapy.

Phase N/A