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Periodontitis Clinical Trials

A listing of Periodontitis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (100) clinical trials

Response to Periodontal Therapy in a Chronic Kidney Disease Population

Dental biofilm is a source of inflammation and infection of periodontal tissues. In the last 20 years the interaction between periodontal infections and systemic conditions has been largely studied, suggesting that the inflammation caused in the periodontal tissues could cause a response in other parts of the body. Recent studies ...

Phase N/A

Correlation Between Oral Health and Systemic Inflammation (COHESION)

The present pilot trial will test the hypothesis that regular brushing with Plaque HD (interventional toothpaste) compared to conventional toothpaste (control) for 30 days in participants with confirmed mild to severe PD will significantly reduce hsCRP levels, a sensitive marker of inflammation and predictor of CVD. By completing the COHESION ...

Phase N/A

Antibiotic and Probiotic Therapies in the Adjuvant Treatment of the Chronic Periodontitis.

Currently, with the increase of bacterial resistance to antibiotics associated with its side effects, it is necessary to find other adjuncts to combat the disease that are an alternative to the use of antibiotics. The use of probiotics has been proposed in the literature as an adjunct therapy for the ...

Phase N/A

The Effectiveness of an Oral Health Education Programme of Adolescents in Hong Kong

Baseline survey and dental examination The baseline survey will collect information on participants' background characteristics (e.g., socio-demographics), Social Cognitive Theory (SCT)-related variables (perceived susceptibility, perceived severity, perceived benefits, perceived barriers, self-efficacy), Health Belief Model (HBM)-related variables (reciprocal determinism, behavioral capability, outcome expectations), and oral health behaviors. Validated scales have been ...

Phase N/A

The Immune Response After Periodontal Treatment

Effective root surface debridement (RSD) is essential for successful periodontal treatment. Myriad studies demonstrate that RSD may be carried out using hand or ulstrasonic instruments with equal efficacy. Locally, effective debridement results in reduced inflammation in the gingival tissues, ultimately preserving the dentition. Systemically, RSD results in an immediate inflammatory ...

Phase N/A

Quantification of CD163 Inflammatory Biomarker in Chronic Periodontitis and Diabetic Subjects

The quantification of CD163 will be analysed in the subgingival plaque samples of generalized chronic periodontitis patients with and without diabetes mellitus. A total of 80 subjects with generalized chronic periodontitis were selected and divided into two groups. Group I comprised of 40 subjects who were diagnosed with generalized chronic ...

Phase N/A

Instrumentation Effectiveness of Modified Area-Specific Hand Scalers During Non-Surgical Periodontal Therapy

Patient selection for this prospective study will be done using a specific inclusion and exclusion criteria listed in the Protocol Registration. In order to recruit participants for this study, scheduled surgeries will be reviewed for possible patient selection meeting the criteria for patient's having extractions of multi-rooted posterior teeth. Patients ...

Phase N/A

Systemic Probiotics in the Periodontal Treatment

The association of scaling and root planing (SRP) with systemic metronidazole (MTZ) and amoxicillin (AMX) has been advocated as one of the most promising therapeutic protocol for the treatment of advanced periodontitis, since the early 2000's. More recently, probiotics has also been suggested as a promising adjunctive treatment for periodontitis ...


Systemic and Local Antimicrobials in the Management of Dental Abscess in Children

This study will comprise of a three-arm, parallel, comparative, randomized treatment of children aged 3 to 11 years presenting with acute odontogenic infection. The three arms of the study includes 1) Odontopaste as a one time intra-canal placement, 2) Calcium hydroxide (gold standard) as a one time intra-canal placement and ...


The Effectiveness of Low-level Laser Therapy in Orthodontic Retention for Periodontal-compromised Patients

The study design is a randomised split-mouth design based on the result of investigator's pilot study. Thirty-five non-smoking Ethnic Chinese patients (male and female, age: 25-65 years) with chronic periodontitis will be recruited. The teeth in experimental group will receive LLLT during orthodontic retention period for 12 months, while the ...

Phase N/A