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Emphysema Clinical Trials

A listing of Emphysema medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (60) clinical trials

Pulmonary Hemodynamics in Patients With Severe Emphysema Pre and Post BLVR

Chronic obstructive pulmonary disease (COPD) continues to be a leading cause of morbidity and is currently the third most common cause of mortality worldwide (1). In most patients with severe COPD, chronic airflow limitation, lung emphysema with parenchymal destruction and the development of air bullae also occur (2-3) Pulmonary hypertension ...

Phase N/A

Prevention of Pneumothorax Following Endoscopic Valve Therapy in Patients With Severe Emphysema

Patient enrolment and data acquisition is to be carried out on a prospective basis. It is planned to enrol a total of 130 patients with advanced emphysema and low collateral ventilation. Patients will be randomly assigned in a 1:1 ratio to receive modified medical care including a 48 bed rest ...

Phase N/A

Clinical Study to Evaluate the Exercise Capacity in Patients With Severe Emphysema Treated With Coils

The study plans to include patients with severe emphysema candidates to go through eLVR with coils that fulfill all inclusion criteria and none of the exclusion criteria. Patients with both homogeneous and heterogeneous emphysema will be included. The main study intervention is the performance of a cyclo ergometry (not included ...

Phase N/A

Spiration Valve System 9 mm European Post Market Evaluation Study

This study is designed to evaluate performance of the 9 mm valve system in patients with at least one airway to be treated . Patients with severe airflow obstruction, severe emphysema, significant hyperinflation, and moderate to severe dyspnea are eligible to be evaluated for enrollment in this study. In this ...

Phase N/A

A Clinical Evaluation of Baofeikang Granule in Combined Pulmonary Fibrosis and Emphysema Treatment

A randomized, double blinded, placebo controlled study is conducted to observe the efficacy and safety of BaoFeiKang Granule in the treatment of patients with Combined Pulmonary Fibrosis and Emphysema. The Traditional Chinese MedicineTCM syndrome intergal,lung function ,Chronic Obstructive Pulmonary Disease Assessment TestCATscore, acute exacerbation, arterial blood gas analysis, chest High ...


Genetics of the Combined Pulmonary Fibrosis and Emphysema Syndrome

The combined pulmonary fibrosis and emphysema syndrome (CPFE) individualized by our group in 2005 is characterized by an often severe dyspnea, almost exclusive male predominance, and often major, profound impairment of gas exchange contrasting with preserved lung volumes and absence of airflow obstruction, and a high risk of pre-capillary pulmonary ...

Phase N/A

Studying the Airway Microenvironment in Patients Undergoing Surgical and Bronchoscopic Interventions for COPD

Chronic obstructive pulmonary disease (COPD) is an umbrella term encompassing two entities causing progressive and ultimately disabling breathlessness. Emphysema is a process destructive of the airspaces distal to the terminal bronchioles, with loss of gas exchange tissue, of elastic recoil and of circumferential tethering of the small airways leading to ...

Phase N/A

BROnchoalveolar Investigations of Never-smokers With Chronic Obstruction From the Swedish CardioPulmonary bioImage Study

Chronic Obstructive Pulmonary Disease (COPD) is an umbrella diagnosis defined by obstructive lung function impairments, and is likely to be caused by a multitude of etiologies including environmental exposures, genetic predispositions and developmental factors. Due to the heterogeneity of the disease, molecular and mechanistic sub-phenotyping of COPD represents an essential ...

Phase N/A

Site and Mechanism(s) of Expiratory Airflow Limitation in COPD Emphysema and Asthma-COPD Overlap

The investigators are interested in determining the predominant site of expiratory airflow limitation including large central airways vs small peripheral airways/alveoli. In mild to moderate obstructive airways disease and emphysema, I believe routine spirometry including FEV 1(L), FVC (L), and FEV 1/FVC % may be normal, despite expiratory airflow limitation ...

Phase N/A

Lung Volume Reduction Coil Microbiome Study

Patients with severe emphysema and hyperinflation can benefit from lung volume reduction techniques designed to reduce gas trapping, improve air flow, and restore more natural chest wall and lung mechanics. The best evidence exists for lung volume reduction surgery (LVRS), but more recently there has been increasing interest in, and ...

Phase N/A