Seasonal Affective Disorder (SAD) Clinical Trials

As a subtype of major depressive disorder, seasonal affective disorder (SAD) or winter depression causes severe reductions in both quality of life and productivity and results in high morbidity and frequent sick leave (1). SAD is a prevalent disorder with rates as high as 3-5% in central European countries and ...

BACKGROUND AND SIGNIFICANCE Discovery in the late 1970s that bright light affects neuroendocrine rhythms such as melatonin secretion, and can reset the circadian pacemaker in humans, paved the way for the discovery that seasonally recurrent fall/winter depressions--christened Seasonal Affective Disorder (SAD)--can be treated with bright light exposure (Lewy et al., ...

Winter seasonal affective disorder (SAD) is a subtype of recurrent depression involving major depressive episodes during the fall and/or winter months that remit each spring. The central public health challenge in the management of SAD is prevention of winter depression recurrences. This application focuses on two SAD treatments that each ...