Open Heart Surgery Clinical Trials

A listing of Open Heart Surgery medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 30 clinical trials
Statin Therapy With Atorvastatin in Surgical Aortic Valve Replacement - a Randomized Controlled Trial (STARC)

> The randomized studie will address 3 separate hypotheses in patients undergoing open heart operation with solitary aortic valve replacement with a bioprosthetic valve that 7 to 14 days

  • 22 Oct, 2022
  • 1 location
Post-Operative Atrial Fibrillation After Surgical Aortic Valve Replacement and the Influence of Statins - Randomized Controlled Trial

with bioprosthesis with prior usage of statins the last 3 months and of at least 7 days. This randomized studies will address 2 separate hypotheses in patients undergoing open heart operation

  • 24 Oct, 2022
  • 1 location
Dexmedetomidine or Clonidine Infusion for Prevention of Delirium After Open Heart Surgery (ALPHA2PREVENT)

for the prevention of delirium and cognitive decline in male and female participants aged 70+ scheduled for open heart surgery.

  • 07 Oct, 2022
  • 4 locations
A Phase 2/3, Multicenter, Randomized, Double-blind, Placebo-Controlled, Adaptive Design Study to Evaluate the Efficacy and Safety of MK-5475 in Adults With Pulmonary Arterial Hypertension

This is a two-part (Phase 2/Phase 3) study of MK-5475, an inhaled soluble guanylate cyclase stimulator, in participants with pulmonary arterial hypertension (PAH). The first part (Phase 2) will assess three different doses of MK-5475 compared to placebo in a base period of 12 weeks, followed by comparison of three …

left ventricular end-diastolic pressure
pulmonary arterial hypertension
right heart catheterization
body mass index
heart disease
  • 20 Oct, 2022
  • 76 locations
The Prophet Trial -Pilot Study to Assess Safety and Efficacy of a Novel Atrial Flow Regulator (AFR) in Patients With Pulmonary Hypertension (AFR-Prophet)

This study aims to investigate safety and efficacy of Occlutech® AFR device in patients with severe pulmonary hypertension (PH).

right ventricular failure
pulmonary arterial pressure
heart failure
  • 07 Oct, 2022
  • 12 locations
A Randomized, Multicenter, Double-Blind, Placebo-Controlled, Parallel-Group, Event-Driven, Group-Sequential Study With Open-Label Extension Period to Assess the Efficacy and Safety of Selexipag as Add-On Treatment to Standard of Care in Children Aged >=2 to <18 Years With Pulmonary Arterial Hypertension (SALTO)

The purpose of this study is to evaluate whether the addition of selexipag to standard of care treatment delays disease progression in children with Pulmonary Arterial Hypertension (PAH) in comparison to placebo.

pulmonary arterial hypertension
primary pulmonary hypertension
right heart catheterization
heart disease
  • 25 Oct, 2022
  • 84 locations
A Study of Ralinepag to Evaluate Effects on Exercise Capacity by CPET in Subjects With WHO Group 1 PH (CAPACITY)

Study ROR-PH-302, ADVANCE CAPACITY, is designed to evaluate the effects of ralinepag therapy on exercise capacity as assessed by change in peak oxygen consumption (VO2) derived from cardiopulmonary exercise testing (CPET) after 28 weeks of treatment

exercise stress test
stress test
cardiopulmonary exercise testing
  • 04 Oct, 2022
  • 36 locations
Benzodiazepine-free Cardiac Anesthesia for Reduction of Postoperative Delirium (B-Free)

B-FREE is a pragmatic, multicentre, cluster crossover trial evaluating whether a policy limiting the use of intra-operative benzodiazepine reduces post-operative delirium when compared with a policy of 'ad libitum' administration. The knowledge generated by this study will provide the basis for cardiac anesthesia practice guidelines.

postoperative delirium
heart surgery
  • 28 Oct, 2022
  • 1 location
Left Atrium Appendage Closure by Surgery-2 (LAACS-2)

Atrial fibrillation is a heart rhythm disorder that often occurs after heart surgery. During atrial fibrillation blood cloths may form, predominantly in the left atrial appendage, a small sac in the wall of the left side of the heart. Some heart surgeons close this appendage to protect against stroke, particularly …

left atrial appendage closure
traumatic brain injury
heart surgery
atrial fibrillation
  • 13 Oct, 2022
  • 4 locations
Health-promoting Family Conversations and Open Heart Surgery -An Intervention Model for Families: The HeartFam Intervention (HeartFam)

Elective open-heart surgery involves physical and psychological strain for the person undergoing surgery. Family plays a significant part in care before and after surgery, and the family has

  • 14 Oct, 2022