Germ Cell Tumors Clinical Trials

A listing of Germ Cell Tumors medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 1052 clinical trials
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A Study of CM24 in Combination With Nivolumab in Adults With Advanced Solid Tumors

This is an open-label, multicenter, multi-dose escalation and dose expansion study in subjects with selected advanced solid tumors (Part A), advanced recurrent immune checkpoint refractory non-small cell lung cancer (NSCLC) (Part B), and metastatic pancreatic cancer (Part C) to evaluate the safety and tolerability of CM-24 in combination with nivolumab. …

lung carcinoma
measurable disease
lung cancer
cancer of the ovary
brain metastases
  • 0 views
  • 28 Oct, 2021
  • 6 locations
None
Stereotactic Body Radiotherapy for Osseous Low Alpha-Beta Resistant Metastases for Pain Relief

Radiation therapy has been shown to be very effective at relieving pain caused by bone metastases. However, certain types of cancers such as prostate, breast, kidney, and melanoma can have resistance to radiation, making treatment less successful. Stereotactic body radiotherapy (SBRT) is a newer form of focused treatment that gives …

cancer
kidney cancer
carcinoma
bone metastases
  • 0 views
  • 10 Aug, 2021
  • 1 location
None
A Study of PRT1419 in Patients With Advanced Solid Tumors

This is a Phase 1 dose-escalation study of PRT1419, a myeloid cell leukemia 1 (MCL1) inhibitor, in patients with advanced solid tumors. The purpose of this study is to define the dosing schedule, maximally tolerated dose and/or estimate the optimal biological dose to be used in subsequent development of PRT1419.

neutrophil count
lung carcinoma
esophagus cancer
lung cancer
absolute neutrophil count
  • 0 views
  • 25 Nov, 2021
  • 4 locations
None
Phase 1a and Phase 2 Study for PK PD Safety and Preliminary Efficacy of ST-067

This is a multicenter Phase 1a open-label, dose escalation study, and a Phase 2 study of ST-067. Phase 1a is a first-in-human (FIH) dose escalation study in patients aged 18 years or older diagnosed with solid tumors who have exhausted available standard. Phase 2 will enroll patients aged 18 years …

lung carcinoma
measurable disease
lung cancer
primary cancer
ovarian cancer
  • 0 views
  • 07 Aug, 2021
  • 2 locations
None
International PPB/DICER1 Registry

Pleuropulmonary blastoma (PPB) is a rare malignant neoplasm of the lung presenting in early childhood. Type I PPB is a purely cystic lesion, Type II is a partially cystic, partially solid tumor, Type III is a completely solid tumor. Treatment of children with PPB is at the discretion of the …

cancer chemotherapy
cancer
solid tumor
initial diagnosis
sarcoma
  • 37 views
  • 08 Aug, 2021
  • 1 location
None
A Phase 1/2 Safety Study of Intratumorally Dosed INT230-6

This study evaluates the intratumoral administration of escalating doses of a novel, experimental drug, INT230-6. The study is being conducted in patients with several types of refractory cancers including those at the surface of the skin (breast, squamous cell, head and neck) and tumors within the body such (pancreatic, colon, …

ipilimumab
combinations
metastasis
yervoy
soft tissue sarcoma
  • 722 views
  • 23 May, 2021
  • 8 locations
None
9-ING-41 in Patients With Advanced Cancers

GSK-3 is a potentially important therapeutic target in human malignancies. The Actuate 1801 Phase 1/2 study is designed to evaluate the safety and efficacy of 9-ING-41, a potent GSK-3 inhibitor, as a single agent and in combination with cytotoxic agents, in patients with refractory cancers.

irinotecan
glioblastoma multiforme
lipase
amylase
metastasis
  • 542 views
  • 01 Aug, 2021
  • 16 locations
None
A Study to Evaluate the Safety and Tolerability of AB154 in Participants With Advanced Malignancies

This is a Phase 1, multicenter, open-label, dose-escalation study to evaluate the safety, tolerability, PK, PD, and clinical activity of domvanalimab (AB154) as monotherapy and in combination with zimberelimab (AB122) in participants with advanced solid malignancies.

measurable disease
immunosuppressant
mammogram
cancer chemotherapy
major surgery
  • 160 views
  • 01 Nov, 2021
  • 21 locations
None
Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies

This is a phase I/II, non randomized, open-label, dose escalation study to investigate the safety, tolerability and preliminary efficacy of CB-103.

hodgkin's disease
metastatic disease
phenytoin
lipase
amylase
  • 281 views
  • 26 Jan, 2021
  • 12 locations
None
Safety Tolerability Pharmacokinetics and Pharmacodynamics of INCB099280 in Participants With Advanced Solid Tumors

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, pharmacodynamics, and early clinical activity of INCB099280 in participants with select solid tumors

solid tumors
solid tumour
  • 1 views
  • 11 Sep, 2021
  • 18 locations