Germ Cell Tumors Clinical Trials

A listing of Germ Cell Tumors medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 1021 clinical trials
Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies (NYMC195)

Investigators are testing new experimental drug combinations such as the combination of vorinostat, vincristine, irinotecan, and temozolomide in the hopes of finding a drug that may be effective against tumors that have come back or that have not responded to standard therapy. The goals of this study are: To find …

renal function
blood transfusion
tumor cells
chemotherapy drugs
neutrophil count
  • 3 views
  • 01 Mar, 2022
  • 1 location
A Phase I Study of Lyso-thermosensitive Liposomal Doxorubicin and MR-HIFU for Pediatric Refractory Solid Tumors

, neuroblastoma, Wilms' tumor, hepatic tumors, and germ cell tumors.

renal function
blood transfusion
neutrophil count
biological products
biological factors
  • 54 views
  • 25 Feb, 2022
  • 1 location
HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors

This is a Phase 1 study of central nervous system (CNS) locoregional adoptive therapy with autologous CD4 and CD8 T cells lentivirally transduced to express a HER2-specific chimeric antigen receptor (CAR) and EGFRt, delivered by an indwelling catheter in the tumor resection cavity or ventricular system in children and young …

erbb2
tumour resection
tumor cells
dexamethasone
HER2
  • 68 views
  • 17 Mar, 2022
  • 1 location
EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors

This is a Phase 1 study of central nervous system (CNS) locoregional adoptive therapy with autologous CD4+ and CD8+ T cells that are lentivirally transduced to express an EGFR806 specific chimeric antigen receptor (CAR) and EGFRt. CAR T cells are delivered via an indwelling catheter into the tumor cavity or …

supratentorial tumors
tumour resection
viral therapy
dexamethasone
tumor resection
  • 3 views
  • 25 Mar, 2022
  • 1 location
Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

This is a Phase 1 study of central nervous system (CNS) locoregional adoptive therapy with autologous CD4+ and CD8+ T cells lentivirally transduced to express a B7H3-specific chimeric antigen receptor (CAR) and EGFRt. CAR T cells are delivered via an indwelling catheter into the tumor resection cavity or ventricular system …

supratentorial tumors
tumour resection
tumor cells
dexamethasone
tumor resection
  • 8 views
  • 09 May, 2022
  • 1 location
Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers

This clinical trial is studying two immunotherapy drugs (nivolumab and ipilimumab) given together as a possible treatment for INI1-negative tumors.

renal function
neutrophil count
absolute neutrophil count
nivolumab
karnofsky performance status
  • 7 views
  • 25 Jul, 2022
  • 7 locations
A Study of DS-9606a in Patients With Advanced Solid Tumors

This study will assess the safety and tolerability of DS-9606a in patients with advanced solid tumors.

cancer
primary peritoneal carcinoma
fallopian tube
carcinoma
peritoneal carcinoma
  • 0 views
  • 12 Jul, 2022
  • 2 locations
SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

Approximately 90% of children with malignant brain tumors that have recurred or relapsed after receiving conventional therapy will die of disease. Despite this terrible and frustrating outcome, continued treatment of this population remains fundamental to improving cure rates. Studying this relapsed population will help unearth clues to why conventional therapy …

filgrastim
sonidegib
ribociclib
conventional treatment
trametinib
  • 224 views
  • 19 Apr, 2022
  • 1 location
Trial of Palbociclib in Second Line of Advanced Sarcomas With CDK4 Overexpression. (PalboSarc)

Non-randomized, open, two-cohort, phase II, multicenter national clinical trial. 20 sites in Spain. Cohort 1 includes soft-tissue sarcoma and osteosarcoma (21 patients), while Cohort 2 includes chordoma patients only (19 patients). Palbociclib will be administered orally at a dose of 125 mg once a day for 21 consecutive days followed …

measurable disease
sarcoma
neutrophil count
absolute neutrophil count
liver metastasis
  • 17 views
  • 18 Jun, 2022
  • 19 locations
B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)

3CAR is being done to investigate an immunotherapy for patients with solid tumors. It is a Phase I clinical trial evaluating the use of autologous T cells genetically engineered to express B7-H3-CARs for patients ≤ 21 years old, with relapsed/refractory B7-H3+ solid tumors. This study will evaluate the safety and …

renal function
serum pregnancy test
cyclophosphamide
neutrophil count
cytokines
  • 0 views
  • 25 Jul, 2022
  • 1 location