Germ Cell Tumors Clinical Trials

A listing of Germ Cell Tumors medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 1020 clinical trials
Tandem Peripheral Blood Stem Cell (PBSC) Rescue for High Risk Solid Tumors

This study uses a double autologous peripheral blood stem cell rescue (PBSC) following dose-intensive chemotherapy for the treatment of high-risk pediatric solid tumors.

high-dose chemotherapy
sarcoma
solid tumour
primitive neuroectodermal tumor
metastatic disease
  • 76 views
  • 07 Nov, 2020
  • 1 location
Continuous 24h Intravenous Infusion of Mithramycin an Inhibitor of Cancer Stem Cell Signaling in People With Primary Thoracic Malignancies or Carcinomas Sarcomas or Germ Cell Neoplasms With Pleuropulmonary Metastases

Background Mithramycin is a new cancer drug. In another study, people with chest cancer took the drug 6 hours a day for 7 straight days. Many of them had liver damage as a side effect. It was discovered that only people with certain genes got this side effect. Researchers want …

sarcoma
ionized calcium
antineoplastic
lung carcinoma
cancer chemotherapy
  • 44 views
  • 21 Sep, 2021
  • 1 location
Clinical Study of an Dendritic and Glioma Cells Fusion Vaccine With IL-12 for Treatment-na ve GBM Patients.

A multi-center, open-label, single-arm, phase I/II clinical study is designed to test the safety and immunogenicity of an investigational Dendritic and Glioma Cells Fusion vaccine given with IL-12 for treatment-nave patients after resection of glioblastoma.

mg++
tumor cells
temozolomide
glioblastoma multiforme
cancer chemotherapy
  • 57 views
  • 24 Jan, 2021
  • 2 locations
A Phase 2 Study of Intravenous AMB-05X in Tenosynovial Giant Cell Tumor Patients

The purpose of this Phase 2, open-label, multiple-dose, dose-escalation study is to evaluate intravenous AMB-05X in the treatment of patients with TGCT.

  • 0 views
  • 18 Jul, 2021
  • 5 locations
Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies

Investigators are testing new experimental drug combinations such as the combination of vorinostat, vincristine, irinotecan, and temozolomide in the hopes of finding a drug that may be effective against tumors that have come back or that have not responded to standard therapy. The goals of this study are: To find …

glomerular filtration rate
tumor cells
stem cell transplantation
solid tumour
pegfilgrastim
  • 3 views
  • 24 Jan, 2021
  • 1 location
A Phase I Study of Lyso-thermosensitive Liposomal Doxorubicin and MR-HIFU for Pediatric Refractory Solid Tumors

, neuroblastoma, Wilms' tumor, hepatic tumors, and germ cell tumors.

myelosuppression chemotherapy
stem cell transplantation
sarcoma
solid tumour
doxorubicin
  • 50 views
  • 03 Mar, 2021
  • 1 location
Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

This is a Phase 1 study of central nervous system (CNS) locoregional adoptive therapy with autologous CD4+ and CD8+ T cells lentivirally transduced to express a B7H3-specific chimeric antigen receptor (CAR) and EGFRt. CAR T cells are delivered via an indwelling catheter into the tumor resection cavity or ventricular system …

central nervous system tumor
tumor cells
diffuse intrinsic pontine glioma
dexamethasone
supratentorial tumors
  • 8 views
  • 22 Mar, 2021
  • 1 location
EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors

This is a Phase 1 study of central nervous system (CNS) locoregional adoptive therapy with autologous CD4+ and CD8+ T cells that are lentivirally transduced to express an EGFR806 specific chimeric antigen receptor (CAR) and EGFRt. CAR T cells are delivered via an indwelling catheter into the tumor cavity or …

central nervous system tumor
viral therapy
dexamethasone
tumor resection
cancer chemotherapy
  • 3 views
  • 23 Mar, 2021
  • 1 location
HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors

This is a Phase 1 study of central nervous system (CNS) locoregional adoptive therapy with autologous CD4 and CD8 T cells lentivirally transduced to express a HER2-specific chimeric antigen receptor (CAR) and EGFRt, delivered by an indwelling catheter in the tumor resection cavity or ventricular system in children and young …

tumor cells
HER2
dexamethasone
immunohistochemistry
tumor resection
  • 55 views
  • 25 Mar, 2021
  • 1 location
Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers

This clinical trial is studying two immunotherapy drugs (nivolumab and ipilimumab) given together as a possible treatment for INI1-negative tumors.

ipilimumab
sarcoma
small molecule
epithelioid sarcoma
nivolumab
  • 7 views
  • 03 Sep, 2021
  • 2 locations