Germ Cell Tumors Clinical Trials

A listing of Germ Cell Tumors medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 1013 clinical trials
Phase 1/2 Study of the Highly-selective RET Inhibitor Pralsetinib (BLU-667) in Patients With Thyroid Cancer Non-Small Cell Lung Cancer and Other Advanced Solid Tumors

This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antineoplastic activity of pralsetinib (BLU-667) administered orally in patients with medullary thyroid cancer, RET-altered NSCLC and other RET-altered solid tumors.

chemotherapy regimen
metastatic cancer
antineoplastic
immunomodulator
mitomycin c
  • 1632 views
  • 09 Sep, 2021
  • 93 locations
Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle

RATIONALE: Imaging procedures, such as MRI and CT scan, may find recurrent cancer. It is not yet known which MRI or CT scan schedule is more effective in finding recurrent cancer. PURPOSE: This randomized phase III trial is comparing four different MRI and CT scan schedules in patients with stage …

ct scan
seminoma
cancer
  • 717 views
  • 07 Nov, 2020
  • 12 locations
Evaluating Immune Therapy Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors

The purpose of this study is to test the safety and effectiveness of durvalumab with tremelimumab in patients with relapsed or refractory germ cell tumors.

platelet count
measurable disease
luteinizing hormone
human chorionic gonadotropin
alpha fetoprotein
  • 26 views
  • 26 Jan, 2021
  • 7 locations
Maintenance Oral Etoposide or Observation Following High-dose Chemo for GCT

This is an open label randomized phase II trial of maintenance oral etoposide vs. observation in patinets with relapsed GCT treated with high-dose chemotherapy (HDCT) and peripheral-blood stem-cell transplant (PBSCT).

etoposide
neutrophil count
high-dose chemotherapy
human chorionic gonadotropin
bleomycin
  • 0 views
  • 04 Sep, 2021
  • 1 location
HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors

) embryonal tumors completing "Head Start 4" Induction. This study will further determine whether the additional labor intensity (duration of hospitalizations and short-term and long-term morbidities

platelet count
neutrophil count
glomerular filtration rate
MRI
medulloblastoma
  • 197 views
  • 30 Apr, 2021
  • 62 locations
Nivolumab With or Without Stereotactic Radiosurgery in Treating Patients With Recurrent Advanced or Metastatic Chordoma

This phase I trial studies the side effects of nivolumab with or without stereotactic radiosurgery (SRS) in treating patients with chordoma that has come back or spread from where it started to other places in the body. Monoclonal antibodies, such as nivolumab, may interfere with the ability of tumor cells …

nivolumab
neutrophil count
measurable disease
MRI Scan
tumor cells
  • 14 views
  • 18 Apr, 2021
  • 2 locations
Afatinib in Locally Advanced and Metastatic Chordoma

In this phase 2, single arm trial patients with locally advanced or metastatic, pathologically proven, EGFR expressing chordoma will be treated with afatinib. Two cohorts of patients will be included: 20 first line patients and 20 second or further line patients. The treatment will be given in 4 week cycles …

absolute neutrophil count
neutrophil count
mg++
metastatic chordoma
renal function
  • 14 views
  • 16 Jun, 2021
  • 3 locations
Pemetrexed for the Treatment of Chordoma

The purpose of this study is to test the safety and tolerability of pemetrexed administered to people with chordoma. Other purposes of this study are to: find out side effects (good and bad) of pemetrexed; learn more about how pemetrexed might affect the growth of cancer cells; evaluate tumor characteristics …

  • 0 views
  • 27 Jan, 2021
  • 1 location
Accelerated v's Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours

The purpose of this study is to determine whether accelerated BEP chemotherapy is more effective than standard BEP chemotherapy in males with intermediate and poor-risk metastatic germ cell tumours.

platelet count
etoposide
neutrophil count
filgrastim
g-csf
  • 50 views
  • 26 Jan, 2021
  • 25 locations
Disulfiram and Cisplatin in Refractory TGCTs.

/refractory germ cell tumors (GCTs).

germ cell cancer
platelet count
cancer
high-dose chemotherapy
measurable disease
  • 15 views
  • 24 Jan, 2021
  • 1 location