Germ Cell Tumors Clinical Trials
A listing of Germ Cell Tumors medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Found 1013 clinical trials
Phase 1/2 Study of the Highly-selective RET Inhibitor Pralsetinib (BLU-667) in Patients With Thyroid Cancer Non-Small Cell Lung Cancer and Other Advanced Solid Tumors
This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antineoplastic activity of pralsetinib (BLU-667) administered orally in patients with medullary thyroid cancer, RET-altered NSCLC and other RET-altered solid tumors.
- 1632 views
- 09 Sep, 2021
- 93 locations
Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle
RATIONALE: Imaging procedures, such as MRI and CT scan, may find recurrent cancer. It is not yet known which MRI or CT scan schedule is more effective in finding recurrent cancer. PURPOSE: This randomized phase III trial is comparing four different MRI and CT scan schedules in patients with stage …
- 717 views
- 07 Nov, 2020
- 12 locations
Evaluating Immune Therapy Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors
The purpose of this study is to test the safety and effectiveness of durvalumab with tremelimumab in patients with relapsed or refractory germ cell tumors.
- 26 views
- 26 Jan, 2021
- 7 locations
Maintenance Oral Etoposide or Observation Following High-dose Chemo for GCT
This is an open label randomized phase II trial of maintenance oral etoposide vs. observation in patinets with relapsed GCT treated with high-dose chemotherapy (HDCT) and peripheral-blood stem-cell transplant (PBSCT).
- 0 views
- 04 Sep, 2021
- 1 location
HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors
) embryonal tumors completing "Head Start 4" Induction. This study will further determine whether the additional labor intensity (duration of hospitalizations and short-term and long-term morbidities
- 197 views
- 30 Apr, 2021
- 62 locations
Nivolumab With or Without Stereotactic Radiosurgery in Treating Patients With Recurrent Advanced or Metastatic Chordoma
This phase I trial studies the side effects of nivolumab with or without stereotactic radiosurgery (SRS) in treating patients with chordoma that has come back or spread from where it started to other places in the body. Monoclonal antibodies, such as nivolumab, may interfere with the ability of tumor cells …
- 14 views
- 18 Apr, 2021
- 2 locations
Afatinib in Locally Advanced and Metastatic Chordoma
In this phase 2, single arm trial patients with locally advanced or metastatic, pathologically proven, EGFR expressing chordoma will be treated with afatinib. Two cohorts of patients will be included: 20 first line patients and 20 second or further line patients. The treatment will be given in 4 week cycles …
- 14 views
- 16 Jun, 2021
- 3 locations
Pemetrexed for the Treatment of Chordoma
The purpose of this study is to test the safety and tolerability of pemetrexed administered to people with chordoma. Other purposes of this study are to: find out side effects (good and bad) of pemetrexed; learn more about how pemetrexed might affect the growth of cancer cells; evaluate tumor characteristics …
- 0 views
- 27 Jan, 2021
- 1 location
Accelerated v's Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours
The purpose of this study is to determine whether accelerated BEP chemotherapy is more effective than standard BEP chemotherapy in males with intermediate and poor-risk metastatic germ cell tumours.
- 50 views
- 26 Jan, 2021
- 25 locations
Disulfiram and Cisplatin in Refractory TGCTs.
/refractory germ cell tumors (GCTs).
- 15 views
- 24 Jan, 2021
- 1 location